ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	IL5RA
Previous Symbol	IL5R
Symbol Alias	CDw125, CD125
Approved Name	interleukin 5 receptor, alpha
Location	3p26-p24
Position	chr3:3111233-3168297, -
External Links	HGNC: 6017 Entrez Gene: 3568 Ensembl: ENSG00000091181 UCSC: uc010hbs.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_15	chr3:2969491-4461303 (NCBI Build 36.1 (hg18))	1538470	3p26.3-3p26.2	Loss

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0038043	interleukin-5-mediated signaling pathway	Biological Process	TAS[1495999]	1
GO:0016021	integral to membrane	Cellular Component		845
GO:0032674	regulation of interleukin-5 production	Biological Process		1
GO:0008283	cell proliferation	Biological Process	TAS[1732409]	60
GO:0007165	signal transduction	Biological Process	TAS[1732409]	171
GO:0005886	plasma membrane	Cellular Component		772
GO:0005615	extracellular space	Cellular Component	TAS[1495999]	126
GO:0005515	protein binding	Molecular Function	IPI[1495999]	910
GO:0004914	interleukin-5 receptor activity	Molecular Function	TAS[1495999]	1
GO:0002437	inflammatory response to antigenic stimulus	Biological Process		2

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04640	Hematopoietic cell lineage	13	Blood-cell development progresses from a hematopoietic stem ...... Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes. More...
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...
hsa04630	Jak-STAT signaling pathway	22	The Janus kinase/signal transducers and activators of transc...... The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors. More...

Genes shared at least 5 GO terms with IL5RA (count: 1)

Gene Symbol	Pathway Count	Pathway List
ERBB2	5	integral to membrane; cell proliferation; signal transduction; plasma membrane; protein binding;

Genes shared at least 2 KEGG pathways with IL5RA (count: 16)

Gene Symbol	Pathway Count	Pathway List
IL11RA	3	Hematopoietic cell lineage; Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL6	3	Hematopoietic cell lineage; Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL7R	3	Hematopoietic cell lineage; Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CLCF1	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CNTF	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CNTFR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CTF1	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
GHR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IFNGR1	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL10RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL12B	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL20RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL22RA2	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
LIFR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
OSMR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
PRLR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;

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Region: chr3:3111233..3168297 View in gBrowse