ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PTPRK
Symbol Alias	R-PTP-kappa
Approved Name	protein tyrosine phosphatase, receptor type, K
Location	6q22.2-q22.3
Position	chr6:128289924-128841870, -
External Links	HGNC: 9674 Entrez Gene: 5796 Ensembl: ENSG00000152894 UCSC: uc010kfc.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_49	chr6:128863230-130509862 (NCBI Build 36.1 (hg18))	1646633	6q22.33-6q23.1	Gain

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
6q22-23	chr6:114600000-139000000	1 (1/0/0)

Gene related GO terms (count: 31)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 31)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005887	integral to plasma membrane	Cellular Component	NAS[9047348]	220
GO:0005515	protein binding	Molecular Function	IPI[19167335]	910
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Molecular Function	NAS[9047348]	5
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	IDA[8663237]	19
GO:0001750	photoreceptor outer segment	Cellular Component		8
GO:0008285	negative regulation of cell proliferation	Biological Process	IDA[18276111]	59
GO:0008013	beta-catenin binding	Molecular Function	IPI[8663237]	10
GO:0007179	transforming growth factor beta receptor signaling pathway	Biological Process	IDA[15899872]	14
GO:0007165	signal transduction	Biological Process	IDA[16849327]	171
GO:0007155	cell adhesion	Biological Process	IMP[15899872]	86
GO:0006470	protein dephosphorylation	Biological Process	IDA[16263724]	18
GO:0005912	adherens junction	Cellular Component		9
GO:0005911	cell-cell junction	Cellular Component	IDA[8663237]	20
GO:0030424	axon	Cellular Component		35
GO:0030425	dendrite	Cellular Component		46
GO:0019901	protein kinase binding	Molecular Function	IPI[15899872]	51
GO:0030336	negative regulation of cell migration	Biological Process	IDA[18276111]	13
GO:0016021	integral to membrane	Cellular Component	NAS[9047348]	845
GO:0016477	cell migration	Biological Process	IMP[15899872]	24
GO:0009986	cell surface	Cellular Component	IDA[18276111]	70
GO:0010839	negative regulation of keratinocyte proliferation	Biological Process	IDA[16263724]	2
GO:0045295	gamma-catenin binding	Molecular Function	IPI[8663237]	6
GO:0045786	negative regulation of cell cycle	Biological Process	IDA[15899872]	9
GO:0035335	peptidyl-tyrosine dephosphorylation	Biological Process	IDA[8663237]	11
GO:0043025	neuronal cell body	Cellular Component		51
GO:0034614	cellular response to reactive oxygen species	Biological Process	IDA[16849327]	5
GO:0034644	cellular response to UV	Biological Process	IDA[16849327]	5
GO:0031256	leading edge membrane	Cellular Component	IDA[15899872]	1
GO:0034394	protein localization to cell surface	Biological Process	IDA[18276111]	4
GO:0048041	focal adhesion assembly	Biological Process	IMP[15899872]	4
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA[18276111]	64

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PTPRK (count: 20)

Gene Symbol	Pathway Count	Pathway List
PTPRJ	11	integral to plasma membrane; protein binding; protein tyrosine phosphatase activity; negative regulation of cell proliferation; beta-catenin binding; cell-cell junction; protein kinase binding; negative regulation of cell migration; cell surface; gamma-catenin binding; peptidyl-tyrosine dephosphorylation;
APC	7	protein binding; negative regulation of cell proliferation; beta-catenin binding; cell adhesion; protein kinase binding; cell migration; gamma-catenin binding;
CNTNAP2	7	signal transduction; cell adhesion; axon; dendrite; integral to membrane; cell surface; neuronal cell body;
DRD2	6	integral to plasma membrane; protein binding; negative regulation of cell proliferation; axon; dendrite; negative regulation of cell migration;
GHR	6	integral to plasma membrane; protein binding; protein kinase binding; integral to membrane; cell surface; neuronal cell body;
THY1	6	integral to plasma membrane; protein binding; dendrite; protein kinase binding; negative regulation of cell migration; focal adhesion assembly;
GSK3B	6	protein binding; beta-catenin binding; protein kinase binding; cell migration; neuronal cell body; negative regulation of transcription, DNA-dependent;
CDH2	6	beta-catenin binding; cell adhesion; cell-cell junction; integral to membrane; cell migration; gamma-catenin binding;
ADAM17	5	integral to plasma membrane; protein binding; cell adhesion; cell-cell junction; cell surface;
NRXN1	5	integral to plasma membrane; protein binding; cell adhesion; integral to membrane; cell surface;
SLC6A3	5	integral to plasma membrane; protein binding; axon; integral to membrane; neuronal cell body;
ACHE	5	protein binding; cell adhesion; axon; dendrite; cell surface;
CADM1	5	protein binding; cell-cell junction; axon; dendrite; integral to membrane;
INHA	5	protein binding; photoreceptor outer segment; signal transduction; negative regulation of cell cycle; neuronal cell body;
MEN1	5	protein binding; negative regulation of cell proliferation; transforming growth factor beta receptor signaling pathway; negative regulation of cell cycle; negative regulation of transcription, DNA-dependent;
MTMR2	5	protein binding; protein tyrosine phosphatase activity; protein dephosphorylation; axon; dendrite;
PAK1	5	protein binding; cell-cell junction; axon; dendrite; protein kinase binding;
PTPN14	5	protein binding; protein tyrosine phosphatase activity; negative regulation of cell proliferation; protein dephosphorylation; peptidyl-tyrosine dephosphorylation;
TXN	5	protein binding; signal transduction; axon; dendrite; neuronal cell body;
NCAM1	5	cell adhesion; axon; integral to membrane; cell surface; neuronal cell body;

Genes shared at least 2 KEGG pathways with PTPRK (count: 0)

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Region: chr6:128289924..128841870 View in gBrowse