ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FGF3
Previous Symbol	INT2
Symbol Alias	HBGF-3
Approved Name	fibroblast growth factor 3
Previous Name	fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)
Name Alias	INT-2 proto-oncogene protein, "oncogene INT2", "V-INT2 murine mammary tumor virus integration site oncogene homolog", "murine mammary tumor virus integration site 2, mouse"
Location	11q13
Position	chr11:69624736-69634192, -
External Links	HGNC: 3681 Entrez Gene: 2248 Ensembl: ENSG00000186895 UCSC: uc001oph.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008083	growth factor activity	Molecular Function		25
GO:0007267	cell-cell signaling	Biological Process	TAS[2470007]	38
GO:0007165	signal transduction	Biological Process	TAS[2470007]	171
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005576	extracellular region	Cellular Component		240
GO:0005515	protein binding	Molecular Function	IPI[16263090]	910
GO:0001759	organ induction	Biological Process		4
GO:0030916	otic vesicle formation	Biological Process		3
GO:0036342	post-anal tail morphogenesis	Biological Process		3
GO:0048538	thymus development	Biological Process		14
GO:0048752	semicircular canal morphogenesis	Biological Process		3
GO:0008284	positive regulation of cell proliferation	Biological Process	IGI[8663044]	69
GO:0008286	insulin receptor signaling pathway	Biological Process		32
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process	IGI[8663044]	26
GO:0009653	anatomical structure morphogenesis	Biological Process	TAS[2470007]	26
GO:0051781	positive regulation of cell division	Biological Process		11
GO:0055026	negative regulation of cardiac muscle tissue development	Biological Process		1

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05218	Melanoma	12	Melanoma is a form of skin cancer that has a poor prognosis ...... Melanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes. The only known environmental risk factor is exposure to ultraviolet (UV) light and in people with fair skin the risk is greatly increased. Melanoma pathogenesis is also driven by genetic factors. Oncogenic NRAS mutations activate both effector pathways Raf-MEK-ERK and PI3K-Akt. The Raf-MEK-ERK pathway may also be activated via mutations in the BRAF gene. The PI3K-Akt pathway may be activated through loss or mutation of the inhibitory tumor suppressor gene PTEN. These mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Melanoma development has been shown to be strongly associated with inactivation of the p16INK4a/cyclin dependent kinases 4 and 6/retinoblastoma protein (p16INK4a/CDK4,6/pRb) and p14ARF/human double minute 2/p53 (p14ARF/HMD2/p53) tumor suppressor pathways. MITF and TP53 are implicated in further melanoma progression. More...
hsa04810	Regulation of actin cytoskeleton	48
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...
hsa05200	Pathways in cancer	52

Genes shared at least 5 GO terms with FGF3 (count: 12)

Gene Symbol	Pathway Count	Pathway List
FGF4	8	growth factor activity; cell-cell signaling; signal transduction; extracellular region; positive regulation of cell proliferation; insulin receptor signaling pathway; fibroblast growth factor receptor signaling pathway; positive regulation of cell division;
FGF9	8	growth factor activity; cell-cell signaling; signal transduction; extracellular region; positive regulation of cell proliferation; insulin receptor signaling pathway; fibroblast growth factor receptor signaling pathway; positive regulation of cell division;
EREG	7	growth factor activity; cell-cell signaling; extracellular region; protein binding; positive regulation of cell proliferation; anatomical structure morphogenesis; positive regulation of cell division;
FGF10	7	growth factor activity; extracellular region; organ induction; otic vesicle formation; thymus development; insulin receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
FGF19	6	growth factor activity; extracellular region; protein binding; positive regulation of cell proliferation; insulin receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
IGF2	6	growth factor activity; extracellular region; protein binding; positive regulation of cell proliferation; insulin receptor signaling pathway; positive regulation of cell division;
MAPK1	6	signal transduction; Golgi apparatus; protein binding; positive regulation of cell proliferation; insulin receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
CTGF	5	growth factor activity; Golgi apparatus; extracellular region; positive regulation of cell proliferation; fibroblast growth factor receptor signaling pathway;
INHA	5	growth factor activity; cell-cell signaling; signal transduction; extracellular region; protein binding;
NTF3	5	growth factor activity; cell-cell signaling; signal transduction; extracellular region; positive regulation of cell proliferation;
VEGFA	5	growth factor activity; extracellular region; protein binding; positive regulation of cell proliferation; positive regulation of cell division;
INS	5	cell-cell signaling; extracellular region; protein binding; positive regulation of cell proliferation; insulin receptor signaling pathway;

Genes shared at least 2 KEGG pathways with FGF3 (count: 20)

Gene Symbol	Pathway Count	Pathway List
FGF10	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
FGF19	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
FGF4	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
FGF9	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
MAPK1	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
MAPK3	4	Melanoma; Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
PIK3CG	3	Melanoma; Regulation of actin cytoskeleton; Pathways in cancer;
PIK3R1	3	Melanoma; Regulation of actin cytoskeleton; Pathways in cancer;
CRKL	3	Regulation of actin cytoskeleton; MAPK signaling pathway; Pathways in cancer;
BAD	2	Melanoma; Pathways in cancer;
CCND1	2	Melanoma; Pathways in cancer;
PDGFD	2	Melanoma; Regulation of actin cytoskeleton;
APC	2	Regulation of actin cytoskeleton; Pathways in cancer;
FN1	2	Regulation of actin cytoskeleton; Pathways in cancer;
ITGA2	2	Regulation of actin cytoskeleton; Pathways in cancer;
PAK1	2	Regulation of actin cytoskeleton; MAPK signaling pathway;
MAPK9	2	MAPK signaling pathway; Pathways in cancer;
PRKCB	2	MAPK signaling pathway; Pathways in cancer;
RELA	2	MAPK signaling pathway; Pathways in cancer;
TGFBR1	2	MAPK signaling pathway; Pathways in cancer;

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Region: chr11:69624736..69634192 View in gBrowse