ADHDgene Database

Gene Report

Basic Info

Approved Symbol	TNFSF18
Symbol Alias	AITRL, TL6, hGITRL
Approved Name	tumor necrosis factor (ligand) superfamily, member 18
Location	1q23
Position	chr1:173009100-173020103, -
External Links	HGNC: 11932 Entrez Gene: 8995 Ensembl: ENSG00000120337 UCSC: uc001giu.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.1	chr1:172900000-176000000	1 (1/0/0)

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007165	signal transduction	Biological Process	TAS[10074428]	171
GO:0005886	plasma membrane	Cellular Component		772
GO:0009986	cell surface	Cellular Component		70
GO:0007267	cell-cell signaling	Biological Process	TAS[10074428]	38
GO:0005125	cytokine activity	Molecular Function		19
GO:0005102	receptor binding	Molecular Function	TAS[10074428]	61
GO:0005615	extracellular space	Cellular Component		126
GO:0005164	tumor necrosis factor receptor binding	Molecular Function		5
GO:0002309	T cell proliferation involved in immune response	Biological Process		2
GO:0042129	regulation of T cell proliferation	Biological Process		1
GO:0033209	tumor necrosis factor-mediated signaling pathway	Biological Process		6
GO:0032813	tumor necrosis factor receptor superfamily binding	Molecular Function		3
GO:0016021	integral to membrane	Cellular Component		845
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process		27
GO:0043066	negative regulation of apoptotic process	Biological Process	TAS[10074428]	77

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...

Genes shared at least 5 GO terms with TNFSF18 (count: 6)

Gene Symbol	Pathway Count	Pathway List
TNFSF15	7	signal transduction; plasma membrane; cytokine activity; receptor binding; extracellular space; tumor necrosis factor receptor binding; integral to membrane;
TNFSF4	7	signal transduction; cell surface; cytokine activity; receptor binding; extracellular space; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding;
TNFSF8	6	signal transduction; cell-cell signaling; cytokine activity; receptor binding; extracellular space; tumor necrosis factor receptor binding;
TNFRSF11A	5	signal transduction; cell-cell signaling; tumor necrosis factor-mediated signaling pathway; integral to membrane; positive regulation of NF-kappaB transcription factor activity;
GREM1	5	cell surface; cell-cell signaling; cytokine activity; extracellular space; positive regulation of NF-kappaB transcription factor activity;
MIF	5	cell surface; cytokine activity; receptor binding; extracellular space; negative regulation of apoptotic process;

Genes shared at least 2 KEGG pathways with TNFSF18 (count: 0)

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Region: chr1:173009100..173020103 View in gBrowse