ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TNFSF4
Previous Symbol	TXGP1
Symbol Alias	OX-40L, gp34, CD252
Approved Name	tumor necrosis factor (ligand) superfamily, member 4
Previous Name	tax-transcriptionally activated glycoprotein 1, 34kD
Location	1q25
Position	chr1:173152870-173176471, -
External Links	HGNC: 11934 Entrez Gene: 7292 Ensembl: ENSG00000117586 UCSC: uc001giw.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.1	chr1:172900000-176000000	1 (1/0/0)

Gene related GO terms (count: 49)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 49)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008203	cholesterol metabolic process	Biological Process		16
GO:0008284	positive regulation of cell proliferation	Biological Process	TAS[7913952]	69
GO:0005887	integral to plasma membrane	Cellular Component	NAS[18397322]	220
GO:0007165	signal transduction	Biological Process	TAS[7913952]	171
GO:0032689	negative regulation of interferon-gamma production	Biological Process		4
GO:0032700	negative regulation of interleukin-17 production	Biological Process	IDA[18501882]	3
GO:0009615	response to virus	Biological Process		21
GO:0009986	cell surface	Cellular Component	IDA[18397322]	70
GO:0032735	positive regulation of interleukin-12 production	Biological Process		7
GO:0032736	positive regulation of interleukin-13 production	Biological Process		1
GO:0032729	positive regulation of interferon-gamma production	Biological Process	IDA[18501882]	9
GO:0032733	positive regulation of interleukin-10 production	Biological Process		4
GO:0032755	positive regulation of interleukin-6 production	Biological Process		5
GO:0032813	tumor necrosis factor receptor superfamily binding	Molecular Function		3
GO:0032743	positive regulation of interleukin-2 production	Biological Process		2
GO:0032753	positive regulation of interleukin-4 production	Biological Process	IDA[18501882]	2
GO:0002526	acute inflammatory response	Biological Process		3
GO:0002215	defense response to nematode	Biological Process		1
GO:0002891	positive regulation of immunoglobulin mediated immune response	Biological Process		1
GO:0002830	positive regulation of type 2 immune response	Biological Process		1
GO:0002819	regulation of adaptive immune response	Biological Process		2
GO:0002726	positive regulation of T cell cytokine production	Biological Process		2
GO:0005615	extracellular space	Cellular Component	IDA[17166734]	126
GO:0005164	tumor necrosis factor receptor binding	Molecular Function		5
GO:0005125	cytokine activity	Molecular Function		19
GO:0005102	receptor binding	Molecular Function	TAS[7913952]	61
GO:0050729	positive regulation of inflammatory response	Biological Process		8
GO:0050871	positive regulation of B cell activation	Biological Process		2
GO:0051024	positive regulation of immunoglobulin secretion	Biological Process		2
GO:0071222	cellular response to lipopolysaccharide	Biological Process		13
GO:0071380	cellular response to prostaglandin E stimulus	Biological Process	IDA[19029446]	1
GO:0071954	chemokine (C-C motif) ligand 11 production	Biological Process		1
GO:1900281	positive regulation of CD4-positive, alpha beta T cell costimulation	Biological Process		1
GO:0035709	memory T cell activation	Biological Process		1
GO:0035708	interleukin-4-dependent isotype switching to IgE isotypes	Biological Process		1
GO:0042098	T cell proliferation	Biological Process		4
GO:0035712	T-helper 2 cell activation	Biological Process		1
GO:0042221	response to chemical stimulus	Biological Process		2
GO:0042104	positive regulation of activated T cell proliferation	Biological Process		6
GO:0043382	positive regulation of memory T cell differentiation	Biological Process		2
GO:0043372	positive regulation of CD4-positive, alpha-beta T cell differentiation	Biological Process		1
GO:0045590	negative regulation of regulatory T cell differentiation	Biological Process		1
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	Biological Process		6
GO:0045630	positive regulation of T-helper 2 cell differentiation	Biological Process		2
GO:0045626	negative regulation of T-helper 1 cell differentiation	Biological Process		1
GO:0046641	positive regulation of alpha-beta T cell proliferation	Biological Process		3
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process		64
GO:0050727	regulation of inflammatory response	Biological Process		8
GO:0050710	negative regulation of cytokine secretion	Biological Process		4

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...

Genes shared at least 5 GO terms with TNFSF4 (count: 10)

Gene Symbol	Pathway Count	Pathway List
IL12B	10	negative regulation of interleukin-17 production; positive regulation of interleukin-12 production; positive regulation of interferon-gamma production; positive regulation of interleukin-10 production; extracellular space; cytokine activity; positive regulation of inflammatory response; cellular response to lipopolysaccharide; positive regulation of activated T cell proliferation; positive regulation of memory T cell differentiation;
TLR4	9	integral to plasma membrane; negative regulation of interferon-gamma production; negative regulation of interleukin-17 production; positive regulation of interleukin-12 production; positive regulation of interferon-gamma production; positive regulation of interleukin-10 production; positive regulation of interleukin-6 production; positive regulation of inflammatory response; cellular response to lipopolysaccharide;
IL6	8	positive regulation of cell proliferation; positive regulation of interleukin-6 production; extracellular space; cytokine activity; positive regulation of B cell activation; positive regulation of immunoglobulin secretion; positive regulation of T-helper 2 cell differentiation; negative regulation of cytokine secretion;
TNFSF18	7	signal transduction; cell surface; tumor necrosis factor receptor superfamily binding; extracellular space; tumor necrosis factor receptor binding; cytokine activity; receptor binding;
TNFSF15	6	integral to plasma membrane; signal transduction; extracellular space; tumor necrosis factor receptor binding; cytokine activity; receptor binding;
TNFSF8	6	integral to plasma membrane; signal transduction; extracellular space; tumor necrosis factor receptor binding; cytokine activity; receptor binding;
GREM1	5	positive regulation of cell proliferation; cell surface; extracellular space; cytokine activity; negative regulation of transcription, DNA-dependent;
CXCL12	5	signal transduction; response to virus; extracellular space; receptor binding; T cell proliferation;
PYCARD	5	signal transduction; positive regulation of interferon-gamma production; positive regulation of interleukin-6 production; cellular response to lipopolysaccharide; positive regulation of activated T cell proliferation;
IL18	5	positive regulation of interferon-gamma production; extracellular space; cytokine activity; positive regulation of inflammatory response; positive regulation of activated T cell proliferation;

Genes shared at least 2 KEGG pathways with TNFSF4 (count: 0)

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Region: chr1:173152870..173176471 View in gBrowse