ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SEMA4D
Previous Symbol	SEMAJ, C9orf164
Symbol Alias	CD100, coll-4, FLJ39737
Approved Name	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Previous Name	chromosome 9 open reading frame 164
Name Alias	M-sema G
Location	9q22-q31
Position	chr9:91975706-92112888, -
External Links	HGNC: 10732 Entrez Gene: 10507 Ensembl: ENSG00000187764 UCSC: uc004aqo.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q22	chr9:90400000-102600000	3 (1/1/1)

Gene related GO terms (count: 29)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 29)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	Biological Process		2
GO:0070486	leukocyte aggregation	Biological Process	IMP[8876214]	1
GO:0071526	semaphorin-plexin signaling pathway	Biological Process	IMP[19788569]	2
GO:1900220	semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis	Biological Process		1
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Biological Process		14
GO:0048814	regulation of dendrite morphogenesis	Biological Process	IMP[19788569]	4
GO:0048672	positive regulation of collateral sprouting	Biological Process	IMP[19788569]	2
GO:0045668	negative regulation of osteoblast differentiation	Biological Process		6
GO:0043931	ossification involved in bone maturation	Biological Process		2
GO:0043066	negative regulation of apoptotic process	Biological Process	TAS[8876214]	77
GO:0032321	positive regulation of Rho GTPase activity	Biological Process	IMP[19788569]	6
GO:0031344	regulation of cell projection organization	Biological Process		1
GO:0030335	positive regulation of cell migration	Biological Process	IDA[16055703]	29
GO:0030215	semaphorin receptor binding	Molecular Function		1
GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	Biological Process	IMP[16055703]	5
GO:0010693	negative regulation of alkaline phosphatase activity	Biological Process		1
GO:0008360	regulation of cell shape	Biological Process		20
GO:0007411	axon guidance	Biological Process		65
GO:0007155	cell adhesion	Biological Process	TAS[8876214]	86
GO:0006955	immune response	Biological Process	TAS[8876214]	45
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component	IDA[8876214]	220
GO:0005515	protein binding	Molecular Function		910
GO:0005615	extracellular space	Cellular Component		126
GO:0004888	transmembrane signaling receptor activity	Molecular Function		20
GO:0005102	receptor binding	Molecular Function	IDA[11254688]	61
GO:0001934	positive regulation of protein phosphorylation	Biological Process	IDA[16055703]	22
GO:0004872	receptor activity	Molecular Function	IDA[15613544]	36
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04360	Axon guidance	25	Axon guidance represents a key stage in the formation of neu...... Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn. More...

Genes shared at least 5 GO terms with SEMA4D (count: 19)

Gene Symbol	Pathway Count	Pathway List
VEGFA	8	positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of apoptotic process; positive regulation of cell migration; regulation of cell shape; protein binding; extracellular space; positive regulation of protein phosphorylation; negative regulation of transcription from RNA polymerase II promoter;
NRXN1	7	axon guidance; cell adhesion; plasma membrane; integral to plasma membrane; protein binding; receptor binding; receptor activity;
INS	6	positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of apoptotic process; positive regulation of cell migration; positive regulation of phosphatidylinositol 3-kinase cascade; protein binding; extracellular space;
ERBB2	6	positive regulation of Rho GTPase activity; axon guidance; plasma membrane; protein binding; transmembrane signaling receptor activity; positive regulation of protein phosphorylation;
ADAM17	6	positive regulation of cell migration; cell adhesion; plasma membrane; integral to plasma membrane; protein binding; positive regulation of protein phosphorylation;
TLR4	6	immune response; plasma membrane; integral to plasma membrane; protein binding; transmembrane signaling receptor activity; receptor activity;
NTF3	5	negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of cell migration; axon guidance; receptor binding;
SEMA3E	5	semaphorin-plexin signaling pathway; regulation of cell shape; axon guidance; extracellular space; receptor activity;
GHR	5	positive regulation of peptidyl-tyrosine phosphorylation; plasma membrane; integral to plasma membrane; protein binding; extracellular space;
MIF	5	positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of apoptotic process; protein binding; extracellular space; receptor binding;
ACHE	5	regulation of dendrite morphogenesis; cell adhesion; plasma membrane; protein binding; extracellular space;
APC	5	negative regulation of apoptotic process; positive regulation of cell migration; cell adhesion; plasma membrane; protein binding;
CXCL12	5	negative regulation of apoptotic process; cell adhesion; immune response; extracellular space; receptor binding;
F7	5	negative regulation of apoptotic process; positive regulation of cell migration; plasma membrane; extracellular space; receptor binding;
FLT4	5	negative regulation of apoptotic process; plasma membrane; integral to plasma membrane; protein binding; positive regulation of protein phosphorylation;
GP1BB	5	cell adhesion; plasma membrane; integral to plasma membrane; protein binding; transmembrane signaling receptor activity;
SPN	5	immune response; plasma membrane; integral to plasma membrane; extracellular space; transmembrane signaling receptor activity;
TNFSF15	5	immune response; plasma membrane; integral to plasma membrane; extracellular space; receptor binding;
CD5	5	plasma membrane; integral to plasma membrane; protein binding; transmembrane signaling receptor activity; receptor activity;

Genes shared at least 2 KEGG pathways with SEMA4D (count: 0)

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Region: chr9:91975706..92112888 View in gBrowse