ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SEMA3E
Previous Symbol	SEMAH
Symbol Alias	M-SemaK, KIAA0331, coll-5
Approved Name	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
Name Alias	M-sema H
Location	7q21.11
Position	chr7:82993222-83278479, -
External Links	HGNC: 10727 Entrez Gene: 9723 Ensembl: ENSG00000170381 UCSC: uc003uhy.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_87	chr7:82863918-83090329 (NCBI Build 35 (hg17))	226412	7q21.11	Deletion (hemizygous)	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001953	negative regulation of cell-matrix adhesion	Biological Process		5
GO:0001569	patterning of blood vessels	Biological Process		7
GO:0004872	receptor activity	Molecular Function		36
GO:0002040	sprouting angiogenesis	Biological Process		4
GO:0005615	extracellular space	Cellular Component	TAS[9515811]	126
GO:0005576	extracellular region	Cellular Component		240
GO:2000249	regulation of actin cytoskeleton reorganization	Biological Process		1
GO:0050808	synapse organization	Biological Process		6
GO:0071526	semaphorin-plexin signaling pathway	Biological Process		2
GO:0016020	membrane	Cellular Component		139
GO:0016525	negative regulation of angiogenesis	Biological Process		5
GO:0007411	axon guidance	Biological Process		65
GO:0008360	regulation of cell shape	Biological Process		20

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04360	Axon guidance	25	Axon guidance represents a key stage in the formation of neu...... Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn. More...

Genes shared at least 5 GO terms with SEMA3E (count: 2)

Gene Symbol	Pathway Count	Pathway List
VEGFA	5	patterning of blood vessels; extracellular space; extracellular region; membrane; regulation of cell shape;
SEMA4D	5	receptor activity; extracellular space; semaphorin-plexin signaling pathway; axon guidance; regulation of cell shape;

Genes shared at least 2 KEGG pathways with SEMA3E (count: 0)

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Region: chr7:82993222..83278479 View in gBrowse