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- Data Summary
Gene Report
Approved Symbol | MAOA |
---|---|
Approved Name | monoamine oxidase A |
Location | Xp11.4-p11.3 |
Position | chrX:43515409-43606068, + |
External Links |
HGNC: 6833 Entrez Gene: 4128 Ensembl: ENSG00000189221 UCSC: uc004dfy.2 |
No. of Studies | 20 (significant: 13; non-significant: 7; trend: 0) |
Source | Literature-origin; Mapped by LD-proxy; Mapped by literature SNP |
Reference | Statistical Values/Author Comments | Result of Statistical Analysis |
---|---|---|
Lung FW, 2006 | No association was found. | Non-significant |
Xu X, 2007(a) | Haplotype test: P-value=0.045, OR=1.25 for 3-G haplotype; P-value=0.048 for 4-T haplotype. A nominally significant association was found between the G-allele of 941G/T in MAO-A and ADHD (P-value=0.034, OR=1.57). Haplotype analysis identified increased transmission of a haplotype consisting of the 3-repeat allele of the promoter VNTR and the G-allele of the 941G/T SNP (P-value=0.045) to ADHD cases which the strong association with the G-allele drove. | Significant |
Nyman ES, 2007 | No evidence of association was seen. | Non-significant |
Guan L, 2009 | haplotype association analysis: P-value=0.023 for ADHD and 0.024 for ADHD-I under individual test, P-value=0.019 for ADHD and 0.011 for ADHD-I under global test. 12 SNPs in this gene achieved significance for ADHD and ADHD-I, and haplotype association test also achieved significance for ADHD and ADHD-I unber both individual and global test. | Significant |
Rommelse NN, 2008 (a) | ATT haplotype P-value=0.025, more common in non-affected siblings compared to affected participants, conferring a protective effect for ADHD in both boys and girls. | Significant |
Biederman J, 2008 | rs3027399 showed a nominally significant effect for females but not for males | Significant |
Gizer IR, 2009 | The present study does not support a relation between ADHD and this gene. | Non-significant |
Ilott NE, 2010 | no SNP showed modest, nominally significant association | Non-significant |
Jiang S, 2000 | The data suggested that ADHD was associated and in linkage with DXS7 locus which is closely linked to MAO genes | Significant |
Payton A, 2001 | there was a trend for preferential transmission of the MAOA 122 bp marker allele | Non-significant |
Jiang S, 2001 | the results showed that ADHD was in linkage with MAOA gene | Significant |
Manor I, 2002 (b) | All three complementary approaches employed (family-based, case-control and quantitative trait design) suggest a role for the MAOA promoter-region polymorphism in conferring risk for ADHD in current patient population. | Significant |
Lawson DC, 2003 | there was no evidence of association between 2 polymorphisms and ADHD using case control analysis; no preferential transmission of alleles was found in the total sample or in the male probands only | Non-significant |
Domschke K, 2005 | A haplotype containing the shorter 3 allele of the 30 bp VNTR and allele 6 of the CA-repeat, famhap global statistic: 24.86, P-value=0.05; a haplotype comprising 3 allele of the 30 bp VNTR, allele 6 of the CA-repeat and the 941G allele was preferentially transmitted to ADHD cases famhap global statistic: 34.54, P-value=0.01; suggested the importance of the 941G/T MAO-A polymorphism in the development of ADHD at least in the Irish population. | Significant |
Das M, 2006 | the short 3.5 repeat allele of the MAOA-u VNTR is probably associated with ADHD in their population and could be the reason for making boys prone to ADHD as compared to girls | Significant |
Brookes K, 2006 | UNPHASED TDT P-value=0.0195, global P-value=0.066; OR=1.31, one or more SNPs with nominal P-value<0.05 located in this gene | Significant |
El-Tarras, A. E., 2012 | These findings support the hypothesis that some of the MAOA and DAT1 polymorphisms have a causative role in the development of ADHD in the Saudi population. | Significant |
Hawi, Z., 2012 | This gene did not show significant association with ADHD. | Non-significant |
Liu, L., 2011 | In conclusion, our results provide some evidence that MAOA may be associated with the ADHD-HI subtype and support the association between MAOA and impulsivity, which may be a potential endophenotype of ADHD. However, the results were strongly influenced by gender. | Significant |
Das M, 2011 | minimum UNPHASED P-value=0.06 for haplotype frequencies in the case-control analysis and minimum ETDT P-value=0.002, X2(1df)=9.7, RR=8.06e+007 in the family-based analysis; COCAPHASE showed a bias in the occurrence of 3R-T haplotype in the ADHD probands supported by significant higher transmission of the haplotype | Significant |
Literature-origin SNPs (count: 21)
rs_ID | Location | Functional Annotation | No. of Studies (significant/non-significant/trend) |
---|---|---|---|
rs1800464 | ChrX:43571197(Fwd) | 5_prime_UTR_variant; nc_transcript_variant; non_coding_exon_variant; synonymous_variant | 2(0/2/0) |
rs6610845 | ChrX:43588010(Fwd) | intron_variant; nc_transcript_variant | 1(0/1/0) |
rs979605 | ChrX:43601363(Fwd) | intron_variant; upstream_gene_variant | 2(0/2/0) |
rs2283724 | ChrX:43559576(Fwd) | intron_variant; nc_transcript_variant | 1(0/1/0) |
rs6323 | ChrX:43591036(Fwd) | downstream_gene_variant; synonymous_variant | 3(0/3/0) |
rs3027407 | ChrX:43604841(Fwd) | 3_prime_UTR_variant; downstream_gene_variant | 3(2/1/0) |
rs3027400 | ChrX:43592763(Fwd) | downstream_gene_variant; intron_variant | 3(3/0/0) |
rs3027399 | ChrX:43592722(Fwd) | downstream_gene_variant; intron_variant | 1(1/0/0) |
rs4570308 | ChrX:43511497(Fwd) | upstream_gene_variant | 1(1/0/0) |
rs12843268 | ChrX:43573666(Fwd) | intron_variant; nc_transcript_variant | 3(2/1/0) |
rs2072744 | ChrX:43599436(Fwd) | intron_variant; upstream_gene_variant | 1(1/0/0) |
rs5905859 | ChrX:43591500(Fwd) | downstream_gene_variant; intron_variant | 2(2/0/0) |
rs5905702 | ChrX:43518188(Fwd) | intron_variant; nc_transcript_variant | 1(0/1/0) |
rs5953210 | ChrX:43514046(Fwd) | upstream_gene_variant | 1(1/0/0) |
rs3788862 | ChrX:43517364(Fwd) | intron_variant; nc_transcript_variant | 1(1/0/0) |
rs3788863 | ChrX:43524765(Fwd) | intron_variant; nc_transcript_variant | 1(1/0/0) |
rs2235186 | ChrX:43595428(Fwd) | downstream_gene_variant; intron_variant | 1(1/0/0) |
rs2239448 | ChrX:43602679(Fwd) | intron_variant; upstream_gene_variant | 3(3/0/0) |
rs1137070 | ChrX:43603391(Fwd) | nc_transcript_variant; non_coding_exon_variant; synonymous_variant | 4(3/1/0) |
rs2235185 | ChrX:43595743(Fwd) | intron_variant | 1(1/0/0) |
rs2205718 | ChrX:43597465(Fwd) | intron_variant | 1(0/1/0) |
LD-proxies (count: 34)
rs_ID | Location | Functional Annotation |
---|---|---|
rs3027397 | ChrX:43557081(Fwd) | intron_variant; nc_transcript_variant |
rs5906957 | ChrX:43547310(Fwd) | intron_variant; nc_transcript_variant |
rs3027398 | ChrX:43557660(Fwd) | intron_variant; nc_transcript_variant |
rs3027396 | ChrX:43554672(Fwd) | intron_variant; nc_transcript_variant |
rs7052785 | ChrX:43609617(Fwd) | downstream_gene_variant |
rs1465107 | ChrX:43538017(Fwd) | intron_variant; nc_transcript_variant |
rs3027409 | ChrX:43607033(Fwd) | downstream_gene_variant |
rs2283725 | ChrX:43559976(Fwd) | intron_variant; nc_transcript_variant |
rs3027406 | ChrX:43602401(Fwd) | intron_variant; upstream_gene_variant |
rs2072743 | ChrX:43599521(Fwd) | intron_variant; upstream_gene_variant |
rs3027405 | ChrX:43596329(Fwd) | intron_variant |
rs6610846 | ChrX:43589464(Fwd) | intron_variant; nc_transcript_variant |
rs3027404 | ChrX:43596221(Fwd) | intron_variant |
rs909525 | ChrX:43553202(Fwd) | intron_variant; nc_transcript_variant |
rs3027392 | ChrX:43551400(Fwd) | intron_variant; nc_transcript_variant |
rs3027401 | ChrX:43593062(Fwd) | downstream_gene_variant; intron_variant |
rs9330645 | ChrX:43568861(Fwd) | intron_variant; nc_transcript_variant |
rs28556796 | ChrX:43580860(Fwd) | intron_variant; nc_transcript_variant |
rs28375424 | ChrX:43567173(Fwd) | intron_variant; nc_transcript_variant |
rs3810709 | ChrX:43587868(Fwd) | intron_variant; nc_transcript_variant |
rs979606 | ChrX:43601142(Fwd) | intron_variant; upstream_gene_variant |
rs6520894 | ChrX:43526548(Fwd) | intron_variant; nc_transcript_variant |
rs5906729 | ChrX:43520371(Fwd) | intron_variant; nc_transcript_variant |
rs4301558 | ChrX:43511454(Fwd) | upstream_gene_variant |
rs5906938 | ChrX:43540295(Fwd) | intron_variant; nc_transcript_variant |
rs1465108 | ChrX:43538209(Fwd) | intron_variant; nc_transcript_variant |
rs5906893 | ChrX:43527624(Fwd) | intron_variant; nc_transcript_variant |
rs5906883 | ChrX:43526943(Fwd) | intron_variant; nc_transcript_variant |
rs28401570 | ChrX:43580261(Fwd) | intron_variant; nc_transcript_variant |
rs1800659 | ChrX:43574169(Fwd) | intron_variant; nc_transcript_variant |
rs5906974 | ChrX:43551321(Fwd) | intron_variant; nc_transcript_variant |
rs5953385 | ChrX:43540837(Fwd) | intron_variant; nc_transcript_variant |
rs3027410 | ChrX:43608067(Fwd) | downstream_gene_variant |
rs2064070 | ChrX:43608682(Fwd) | downstream_gene_variant |
Variant Name | Variant Type | Location in Gene | No. of Studies (significant/non-significant/trend) |
---|---|---|---|
MAOA_DXS7 | microsatellite | Xp11.23-Xp11.4, linked to the MAO gene | 2 (1/1/0) |
MAOA_promoter_VNTR | VNTR | promoter, 1.2kb upstream of the coding region | 11 (3/8/0) |
MAOA_exon8_941G/T | point mutation | exon 8 | 3 (2/1/0) |
MAOA_intron2_CA(n) | microsatellite | intron 2 | 3 (1/2/0) |
GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)
GO terms by database search (count: 12)
ID | Name | Type | Evidence[PMID] | No. of Genes in ADHDgene |
---|---|---|---|---|
GO:0005741 | mitochondrial outer membrane | Cellular Component | 21 | |
GO:0006576 | cellular biogenic amine metabolic process | Biological Process | TAS[8211186] | 1 |
GO:0006805 | xenobiotic metabolic process | Biological Process | 25 | |
GO:0044281 | small molecule metabolic process | Biological Process | 248 | |
GO:0016021 | integral to membrane | Cellular Component | 845 | |
GO:0042135 | neurotransmitter catabolic process | Biological Process | 4 | |
GO:0042136 | neurotransmitter biosynthetic process | Biological Process | 6 | |
GO:0042420 | dopamine catabolic process | Biological Process | 4 | |
GO:0007268 | synaptic transmission | Biological Process | 96 | |
GO:0007269 | neurotransmitter secretion | Biological Process | 18 | |
GO:0007610 | behavior | Biological Process | TAS[8211186] | 10 |
GO:0008131 | primary amine oxidase activity | Molecular Function | 2 |
ID | Name | No. of Genes in ADHDgene | Brief Description |
---|---|---|---|
hsa00380 | Tryptophan metabolism | 12 | |
hsa01100 | Metabolic pathways | 237 | |
hsa00330 | Arginine and proline metabolism | 13 | |
hsa00260 | Glycine, serine and threonine metabolism | 6 | Serine is derived from 3-phospho-D-glycerate, an intermediat...... Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018]. More... |
hsa00360 | Phenylalanine metabolism | 8 | |
hsa00350 | Tyrosine metabolism | 15 | |
hsa00982 | Drug metabolism - cytochrome P450 | 29 | |
hsa00340 | Histidine metabolism | 12 |
Region: chrX:43515409..43606068 View in gBrowse
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014