ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol MAOA
Approved Name monoamine oxidase A
Location Xp11.4-p11.3
Position chrX:43515467-43606068, 1
External Links HGNC: 6833
Entrez Gene: 4128
Ensembl: ENSG00000189221
UCSC: uc004dfy.4
No. of Studies 20 (significant: 13; non-significant: 7; trend: 0)
Source Literature-origin; Mapped by Literature SNP

Gene related studies (count: 20)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Manor I, 2002 (b) All three complementary approaches employed (family-based, case-control and quantitative trait design) suggest a role for the MAOA promoter-region polymorphism in conferring risk for ADHD in current patient population. Significant
Hawi, Z., 2012 This gene did not show significant association with ADHD. Non-significant
Rommelse NN, 2008 (a) ATT haplotype P-value=0.025, more common in non-affected siblings compared to affected participants, conferring a protective effect for ADHD in both boys and girls. Significant
Gizer IR, 2009 The present study does not support a relation between ADHD and this gene. Non-significant
Xu X, 2007(a) Haplotype test: P-value=0.045, OR=1.25 for 3-G haplotype; P-value=0.048 for 4-T haplotype. A nominally significant association was found between the G-allele of 941G/T in MAO-A and ADHD (P-value=0.034, OR=1.57). Haplotype analysis identified increased transmission of a haplotype consisting of the 3-repeat allele of the promoter VNTR and the G-allele of the 941G/T SNP (P-value=0.045) to ADHD cases which the strong association with the G-allele drove. Significant
Lawson DC, 2003 there was no evidence of association between 2 polymorphisms and ADHD using case control analysis; no preferential transmission of alleles was found in the total sample or in the male probands only Non-significant
Ilott NE, 2010 no SNP showed modest, nominally significant association Non-significant
Brookes K, 2006 UNPHASED TDT P-value=0.0195, global P-value=0.066; OR=1.31, one or more SNPs with nominal P-value<0.05 located in this gene Significant
Biederman J, 2008 rs3027399 showed a nominally significant effect for females but not for males Significant
Liu, L., 2011 In conclusion, our results provide some evidence that MAOA may be associated with the ADHD-HI subtype and support the association between MAOA and impulsivity, which may be a potential endophenotype of ADHD. However, the results were strongly influenced by gender. Significant
Jiang S, 2001 the results showed that ADHD was in linkage with MAOA gene Significant
Jiang S, 2000 The data suggested that ADHD was associated and in linkage with DXS7 locus which is closely linked to MAO genes Significant
Guan L, 2009 haplotype association analysis: P-value=0.023 for ADHD and 0.024 for ADHD-I under individual test, P-value=0.019 for ADHD and 0.011 for ADHD-I under global test. 12 SNPs in this gene achieved significance for ADHD and ADHD-I, and haplotype association test also achieved significance for ADHD and ADHD-I unber both individual and global test. Significant
Lung FW, 2006 No association was found. Non-significant
El-Tarras, A. E., 2012 These findings support the hypothesis that some of the MAOA and DAT1 polymorphisms have a causative role in the development of ADHD in the Saudi population. Significant
Nyman ES, 2007 No evidence of association was seen. Non-significant
Domschke K, 2005 A haplotype containing the shorter 3 allele of the 30 bp VNTR and allele 6 of the CA-repeat, famhap global statistic: 24.86, P-value=0.05; a haplotype comprising 3 allele of the 30 bp VNTR, allele 6 of the CA-repeat and the 941G allele was preferentially transmitted to ADHD cases famhap global statistic: 34.54, P-value=0.01; suggested the importance of the 941G/T MAO-A polymorphism in the development of ADHD at least in the Irish population. Significant
Payton A, 2001 there was a trend for preferential transmission of the MAOA 122 bp marker allele Non-significant
Das M, 2011 minimum UNPHASED P-value=0.06 for haplotype frequencies in the case-control analysis and minimum ETDT P-value=0.002, X2(1df)=9.7, RR=8.06e+007 in the family-based analysis; COCAPHASE showed a bias in the occurrence of 3R-T haplotype in the ADHD probands supported by significant higher transmission of the haplotype Significant
Das M, 2006 the short 3.5 repeat allele of the MAOA-u VNTR is probably associated with ADHD in their population and could be the reason for making boys prone to ADHD as compared to girls Significant

Gene related SNPs (count: 55)

Literature-origin SNPs (count: 21)

LD-proxies (count: 34)

Gene related CNVs (count: 0)

Gene related other variant (count: 4)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

Gene related KEGG pathways (count: 7)

Genes shared at least 5 GO terms with MAOA (count: 2)

Genes shared at least 2 KEGG pathways with MAOA (count: 12)

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Region: chrX:43515467..43606068 View in gBrowse
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