ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol MAOA
Approved Name monoamine oxidase A
Location Xp11.4-p11.3
Position chrX:43515409-43606068, +
External Links HGNC: 6833
Entrez Gene: 4128
Ensembl: ENSG00000189221
UCSC: uc004dfy.2
No. of Studies 20 (significant: 13; non-significant: 7; trend: 0)
Source Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 20)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Lung FW, 2006 No association was found. Non-significant
Xu X, 2007(a) Haplotype test: P-value=0.045, OR=1.25 for 3-G haplotype; P-value=0.048 for 4-T haplotype. A nominally significant association was found between the G-allele of 941G/T in MAO-A and ADHD (P-value=0.034, OR=1.57). Haplotype analysis identified increased transmission of a haplotype consisting of the 3-repeat allele of the promoter VNTR and the G-allele of the 941G/T SNP (P-value=0.045) to ADHD cases which the strong association with the G-allele drove. Significant
Nyman ES, 2007 No evidence of association was seen. Non-significant
Guan L, 2009 haplotype association analysis: P-value=0.023 for ADHD and 0.024 for ADHD-I under individual test, P-value=0.019 for ADHD and 0.011 for ADHD-I under global test. 12 SNPs in this gene achieved significance for ADHD and ADHD-I, and haplotype association test also achieved significance for ADHD and ADHD-I unber both individual and global test. Significant
Rommelse NN, 2008 (a) ATT haplotype P-value=0.025, more common in non-affected siblings compared to affected participants, conferring a protective effect for ADHD in both boys and girls. Significant
Biederman J, 2008 rs3027399 showed a nominally significant effect for females but not for males Significant
Gizer IR, 2009 The present study does not support a relation between ADHD and this gene. Non-significant
Ilott NE, 2010 no SNP showed modest, nominally significant association Non-significant
Jiang S, 2000 The data suggested that ADHD was associated and in linkage with DXS7 locus which is closely linked to MAO genes Significant
Payton A, 2001 there was a trend for preferential transmission of the MAOA 122 bp marker allele Non-significant
Jiang S, 2001 the results showed that ADHD was in linkage with MAOA gene Significant
Manor I, 2002 (b) All three complementary approaches employed (family-based, case-control and quantitative trait design) suggest a role for the MAOA promoter-region polymorphism in conferring risk for ADHD in current patient population. Significant
Lawson DC, 2003 there was no evidence of association between 2 polymorphisms and ADHD using case control analysis; no preferential transmission of alleles was found in the total sample or in the male probands only Non-significant
Domschke K, 2005 A haplotype containing the shorter 3 allele of the 30 bp VNTR and allele 6 of the CA-repeat, famhap global statistic: 24.86, P-value=0.05; a haplotype comprising 3 allele of the 30 bp VNTR, allele 6 of the CA-repeat and the 941G allele was preferentially transmitted to ADHD cases famhap global statistic: 34.54, P-value=0.01; suggested the importance of the 941G/T MAO-A polymorphism in the development of ADHD at least in the Irish population. Significant
Das M, 2006 the short 3.5 repeat allele of the MAOA-u VNTR is probably associated with ADHD in their population and could be the reason for making boys prone to ADHD as compared to girls Significant
Brookes K, 2006 UNPHASED TDT P-value=0.0195, global P-value=0.066; OR=1.31, one or more SNPs with nominal P-value<0.05 located in this gene Significant
El-Tarras, A. E., 2012 These findings support the hypothesis that some of the MAOA and DAT1 polymorphisms have a causative role in the development of ADHD in the Saudi population. Significant
Hawi, Z., 2012 This gene did not show significant association with ADHD. Non-significant
Liu, L., 2011 In conclusion, our results provide some evidence that MAOA may be associated with the ADHD-HI subtype and support the association between MAOA and impulsivity, which may be a potential endophenotype of ADHD. However, the results were strongly influenced by gender. Significant
Das M, 2011 minimum UNPHASED P-value=0.06 for haplotype frequencies in the case-control analysis and minimum ETDT P-value=0.002, X2(1df)=9.7, RR=8.06e+007 in the family-based analysis; COCAPHASE showed a bias in the occurrence of 3R-T haplotype in the ADHD probands supported by significant higher transmission of the haplotype Significant

Gene related SNPs (count: 55)

Literature-origin SNPs (count: 21)

LD-proxies (count: 34)

Gene related CNVs (count: 0)

Gene related other variant (count: 4)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

Gene related KEGG pathways (count: 8)

Genes shared at least 5 GO terms with MAOA (count: 2)

Genes shared at least 2 KEGG pathways with MAOA (count: 58)

View in gBrowse

Region: chrX:43515409..43606068 View in gBrowse
View in gBrowse