ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Lung FW, 200617230031
Citation	Lung F. W., Yang P., Cheng T. S. and Kao W. T. (2006) "No allele variation of the MAOA gene promoter in male Chinese subjects with attention deficit hyperactivity disorder." Neuropsychobiology, 54(3): 147-51.
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	57 cases and 187 controls
Predominant Ethnicity	Mongoloid
Population	Taiwan
Gender	100% male
Age Group	Children/Adolescents : mean age 8.19 years (SD=3.07) for case, mean age 46.34 years (SD=14.49) for control

Detail Info

Summary	The aim of the current study was to examine any difference in the repeat sequence of the monoamine oxidase A (MAOA) gene promoter between males with attention deficit hyperactivity disorder (ADHD) and randomly selected subjects in a community. The role of the MAOA gene promoter in ADHD cases was also investigated. The total of 244 participants included 57 male ADHD subjects as the case group and 187 males, also in southern Taiwan, as the community controls. There was no significantly different distribution in the repeat sequence of the MAOA gene promoter, and no significantly different distribution of long-form and short-form alleles between the ADHD group and the male community group was noted. Some aspects of clinical response are mentioned in the discussion of this study which are worth exploring further in the future.
Total Sample	This study consisted of 57 male ADHD patients, who were treated at the psychiatric outpatient department of a university hospital in southern Taiwan. A stratified random household sample was selected from the general population of Tainan City in southern Taiwan. The research subjects were invited to attend a health-screening program. All the data were collected between 1998 and 1999. Of the 1,231 healthy adults aged 20 years and older who attended the health-screening program and were recruited for the interview survey, 187 male participants agreed to have an additional venous blood withdrawal for DNA extraction and genetic study. No participant was referred with any psychiatric disorders or symptoms included in the DSM-IV.
Sample Collection	This study consisted of 57 male ADHD patients, who were treated at the psychiatric outpatient department of a university hospital in southern Taiwan.
Diagnosis Description	ADHD patients were all interviewed face to face by the same senior psychiatrist, and fulfilled the criteria for ADHD according to the DSM-IV. All participants were required to have a full-scale IQ score of more than 70, using the WISC-III, to exclude mental retardation for this study. No participant was referred with conduct disorder, pervasive developmental disorder, or other psychiatric disorders and symptoms included in the DSM-IV, with the exception of ADHD. Other ethnic groups, such as aboriginals, persons of mixed blood and those with fragile X syndrome were excluded from this study, which was limited to the Han Chinese population.
Technique	Genomic DNA was prepared from peripheral blood. DNA extraction was performed using the Nucleospin Blood kit (Macherey-Nagel, Germany) according to the manufacturer's recommendation. Genotyping of the VNTR of MAOA was conducted by PCR.
Analysis Method	Data were analyzed using the SPSS 10.0 for Windows statistical software package. The Pearson chi-square test was used to describe the different distributions noted in the repeat sequences of the MAOA promoter polymorphism between the ADHD and the community group. A value of P-value<0.05 was considered statistically significant.
Result Description	There was no significantly different distribution in the repeat sequence of the MAOA gene promoter between males with ADHD and community controls. No significantly different distributions of the long-form and short-form alleles were shown between the two groups.

Other variant reported by this study (count: 1)

Variant Name	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
MAOA promoter VNTR			Chi-square test: P-value=0.273 (df=3) for allele, P-value=0....... Chi-square test: P-value=0.273 (df=3) for allele, P-value=0.155 (df=1) for long/short form alleles More...	No association was found.	Non-significant

Genes reported by this study (count: 1)