ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Other Variant Report

Basic Info
Name MAOA_promoter_VNTR
Type VNTR
Location promoter, 1.2kb upstream of the coding region
Length of Repeat Unit 30bp
Related Gene MAOA
No. of Study 11 (significant: 3; non-significant 8; trend: 0)

Variant related studies (count: 11)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Ilott NE, 2010 QTDT AW P-value=0.2, X2=4.68, df=3 at age 2; QTDT...... QTDT AW P-value=0.2, X2=4.68, df=3 at age 2; QTDT AW P-value=0.81, X2=0.05, df=3 at age 3 More... no significant association no significant association Non-significant
Das M, 2006 3.5 repeat allele LRS=5.365, df=1, P-value=0.02, OR=1 in COC...... 3.5 repeat allele LRS=5.365, df=1, P-value=0.02, OR=1 in COCAPHASE Analysis; LRS=2.29, df=1, HHRR P-value=0.13, OR=1 for full sample and 3.5 repeat allele HHRR P-value=0.005, LRS=7.97, df=1, OR=1 for male probands based on unphased data in TDTPHASE Analysis; 3.5 repeat allele ETDT P-value=0.046, LRS=3.985, df=1 for male probands based on phased data in TDTPHASE Analysis More... the short 3.5 repeat allele of the MAOA-u VNTR is probably a...... the short 3.5 repeat allele of the MAOA-u VNTR is probably associated with ADHD in their population and could be the reason for making boys prone to ADHD as compared to girls More... Significant
Domschke K, 2005 allelic TDT P-value=0.39, X2=0.9, df=1 allelic TDT P-value=0.39, X2=0.9, df=1 did not show any significant distortion in the transmission ...... did not show any significant distortion in the transmission to ADHD cases More... Non-significant
Gizer IR, 2009 Meta-analysis model: Random: OR=1.02, 95% CI=0.72-1.43, P-va...... Meta-analysis model: Random: OR=1.02, 95% CI=0.72-1.43, P-value=0.464; Q-statistic: P-value=0.009, I2=67 More... no evidence to suggest an association between this polymorph...... no evidence to suggest an association between this polymorphisms and ADHD More... Non-significant
Nyman ES, 2007 No available information. No available information. No evidence of association was seen. No evidence of association was seen. Non-significant
El-Tarras, A. E., 2012 allelic P-value=0.1, OR=1.4, CI=0.9-2.1 for allele 2; P-valu...... allelic P-value=0.1, OR=1.4, CI=0.9-2.1 for allele 2; P-value=0.07, OR=0.7, CI=0.5-1.0 for allele 3; P-value=0.5, OR=1.1, CI=0.8-1.6 for allele 4; P-value=0.9, OR=1, CI=0.7-1.3 for allele 5; P-value=0.6, OR=0.9, CI=0.7-1.3 for short allele; P-value=0.6, OR=1.1, CI=0.8-1.5 for long allele; genotypic P-value=0.01, OR=0.4, CI=0.2-0.8 for 3/3; P-value=0.5, OR=1.3, CI=0.5-3.5 for 3/5; P-value<0.01, OR=3, CI=1.3-7.0 for 3/4; P-value<0.01, OR=4.9, CI=2.4-11.1 for 4/4; P-value=0.7, OR=0.9, CI=0.5-1.6; P-value=0.8, OR=0.9, CI=0.4-2.0 for 5/5; P-value=0.8, OR=0.9, CI=0.4-2.0 for 4/5; P-value=0.3, OR=0.6, CI=0.2-1.4 More... MAOA genotypes 3/4 and 3/2 showed highly significant associa...... MAOA genotypes 3/4 and 3/2 showed highly significant association with ADHD (OR = 3 and 4.9) respectively, while no significant association was fond with MAOA alleles. It is also worth to mention that the P value for association with genotype 3 was 0.07 which is not very far from the level of significance. More... Significant
Lawson DC, 2003 allelic TDT P-value=0.45, X2(1df)=0.58 in full sa...... allelic TDT P-value=0.45, X2(1df)=0.58 in full sample, allelic TDT P-value=0.25, X2(1df)=1.32 in male probands; More... there was no evidence of association with ADHD using case co...... there was no evidence of association with ADHD using case control analysis; no preferential transmission of alleles was found in the total sample or in the male probands only More... Non-significant
Manor I, 2002 (b) 2-5 repeat long repeat (4,5R) Family-based TDT P-value=0.036; case-control allele test Pea...... Family-based TDT P-value=0.036; case-control allele test Pearson P-value=0.047 (df=3) for male sample; case-control genotype P-value=0.0032 (df=3), allele P-value=0.0007 (df=2) for female sample More... preferential transmission of the long alleles was observed. ...... preferential transmission of the long alleles was observed. In case-control analysis, significant difference in allele frequency was also observed. More... Significant
Lung FW, 2006 Chi-square test: P-value=0.273 (df=3) for allele, P-value=0....... Chi-square test: P-value=0.273 (df=3) for allele, P-value=0.155 (df=1) for long/short form alleles More... No association was found. No association was found. Non-significant
Das M, 2011 ETDT P-value=0.63, X2(1df)=0.23, RR=1; allelic fr...... ETDT P-value=0.63, X2(1df)=0.23, RR=1; allelic frequencies COCAPHASE P-value=0.57, X2=0.33 for 3R; ETDT P-value=0.63, X2(1df)=0.23, RR=0.86; allelic frequencies COCAPHASE P-value=0.57, X2=0.33 for 4R More... the data was statistically not significant in either case-co...... the data was statistically not significant in either case-control or family-based analysis More... Non-significant
Xu X, 2007(a) Single marker TDT P-value=0.120 Single marker TDT P-value=0.120 The association was not significant The association was not significant Non-significant