ADHDgene Database
  • Hot Results
  • Quick Search
Keyword:
Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Other Variant Report

Basic Info
Name MAOA_promoter_VNTR
Type VNTR
Location promoter, 1.2kb upstream of the coding region
Length of Repeat Unit 30bp
Related Gene MAOA
No. of Study 11 (significant: 3; non-significant 8; trend: 0)

Variant related studies (count: 11)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Das M, 2011 ETDT P-value=0.63, X2(1df)=0.23, RR=1; allelic fr...... ETDT P-value=0.63, X2(1df)=0.23, RR=1; allelic frequencies COCAPHASE P-value=0.57, X2=0.33 for 3R; ETDT P-value=0.63, X2(1df)=0.23, RR=0.86; allelic frequencies COCAPHASE P-value=0.57, X2=0.33 for 4R More... the data was statistically not significant in either case-co...... the data was statistically not significant in either case-control or family-based analysis More... Non-significant
Ilott NE, 2010 QTDT AW P-value=0.2, X2=4.68, df=3 at age 2; QTDT...... QTDT AW P-value=0.2, X2=4.68, df=3 at age 2; QTDT AW P-value=0.81, X2=0.05, df=3 at age 3 More... no significant association no significant association Non-significant
Gizer IR, 2009 Meta-analysis model: Random: OR=1.02, 95% CI=0.72-1.43, P-va...... Meta-analysis model: Random: OR=1.02, 95% CI=0.72-1.43, P-value=0.464; Q-statistic: P-value=0.009, I2=67 More... no evidence to suggest an association between this polymorph...... no evidence to suggest an association between this polymorphisms and ADHD More... Non-significant
Nyman ES, 2007 No available information. No available information. No evidence of association was seen. No evidence of association was seen. Non-significant
El-Tarras, A. E., 2012 allelic P-value=0.1, OR=1.4, CI=0.9-2.1 for allele 2; P-valu...... allelic P-value=0.1, OR=1.4, CI=0.9-2.1 for allele 2; P-value=0.07, OR=0.7, CI=0.5-1.0 for allele 3; P-value=0.5, OR=1.1, CI=0.8-1.6 for allele 4; P-value=0.9, OR=1, CI=0.7-1.3 for allele 5; P-value=0.6, OR=0.9, CI=0.7-1.3 for short allele; P-value=0.6, OR=1.1, CI=0.8-1.5 for long allele; genotypic P-value=0.01, OR=0.4, CI=0.2-0.8 for 3/3; P-value=0.5, OR=1.3, CI=0.5-3.5 for 3/5; P-value<0.01, OR=3, CI=1.3-7.0 for 3/4; P-value<0.01, OR=4.9, CI=2.4-11.1 for 4/4; P-value=0.7, OR=0.9, CI=0.5-1.6; P-value=0.8, OR=0.9, CI=0.4-2.0 for 5/5; P-value=0.8, OR=0.9, CI=0.4-2.0 for 4/5; P-value=0.3, OR=0.6, CI=0.2-1.4 More... MAOA genotypes 3/4 and 3/2 showed highly significant associa...... MAOA genotypes 3/4 and 3/2 showed highly significant association with ADHD (OR = 3 and 4.9) respectively, while no significant association was fond with MAOA alleles. It is also worth to mention that the P value for association with genotype 3 was 0.07 which is not very far from the level of significance. More... Significant
Manor I, 2002 (b) 2-5 repeat long repeat (4,5R) Family-based TDT P-value=0.036; case-control allele test Pea...... Family-based TDT P-value=0.036; case-control allele test Pearson P-value=0.047 (df=3) for male sample; case-control genotype P-value=0.0032 (df=3), allele P-value=0.0007 (df=2) for female sample More... preferential transmission of the long alleles was observed. ...... preferential transmission of the long alleles was observed. In case-control analysis, significant difference in allele frequency was also observed. More... Significant
Lawson DC, 2003 allelic TDT P-value=0.45, X2(1df)=0.58 in full sa...... allelic TDT P-value=0.45, X2(1df)=0.58 in full sample, allelic TDT P-value=0.25, X2(1df)=1.32 in male probands; More... there was no evidence of association with ADHD using case co...... there was no evidence of association with ADHD using case control analysis; no preferential transmission of alleles was found in the total sample or in the male probands only More... Non-significant
Lung FW, 2006 Chi-square test: P-value=0.273 (df=3) for allele, P-value=0....... Chi-square test: P-value=0.273 (df=3) for allele, P-value=0.155 (df=1) for long/short form alleles More... No association was found. No association was found. Non-significant
Xu X, 2007(a) Single marker TDT P-value=0.120 Single marker TDT P-value=0.120 The association was not significant The association was not significant Non-significant
Domschke K, 2005 allelic TDT P-value=0.39, X2=0.9, df=1 allelic TDT P-value=0.39, X2=0.9, df=1 did not show any significant distortion in the transmission ...... did not show any significant distortion in the transmission to ADHD cases More... Non-significant
Das M, 2006 3.5 repeat allele LRS=5.365, df=1, P-value=0.02, OR=1 in COC...... 3.5 repeat allele LRS=5.365, df=1, P-value=0.02, OR=1 in COCAPHASE Analysis; LRS=2.29, df=1, HHRR P-value=0.13, OR=1 for full sample and 3.5 repeat allele HHRR P-value=0.005, LRS=7.97, df=1, OR=1 for male probands based on unphased data in TDTPHASE Analysis; 3.5 repeat allele ETDT P-value=0.046, LRS=3.985, df=1 for male probands based on phased data in TDTPHASE Analysis More... the short 3.5 repeat allele of the MAOA-u VNTR is probably a...... the short 3.5 repeat allele of the MAOA-u VNTR is probably associated with ADHD in their population and could be the reason for making boys prone to ADHD as compared to girls More... Significant

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014