ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

SNP Report

Basic Info
Name rs2239448 dbSNP Ensembl
Location chrX:43602679(Fwd)
Variant Alleles T/C
Ancestral Allele C
Functional Annotation intron_variant; upstream_gene_variant.
Consequence to Transcript intron_variant(ENST00000338702; ENST00000542639)
upstream_gene_variant(ENST00000490604)
No. of Studies 3 (significant: 3; non-significant: 0; trend: 0)
Source Literature-origin

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Liu, L., 2011 T TDT P-value=0.480 in all ADHD, P-value=0.155 in male ADHD, P...... TDT P-value=0.480 in all ADHD, P-value=0.155 in male ADHD, P-value=0.170 in female ADHD; P-value=0.671 in all ADHD-I, P-value=0.216 in male ADHD-I, P-value=0.152 in female ADHD-I; P-value=0.856 in all ADHD-C, P-value=0.948 in male ADHD-C, P-value=0.527 in female ADHD-C; Nominal P-value=0.024, Empirical P-value=0.067, X2=5.121 in ADHD-HI Trios; Nominal P-value=0.023, Empirical P-value=0.039, X2=5.143; Logistic Regression, P-value=0.806, OR=1.013; P-value<0.001, OR=0.982 after controlling for potentially confounding factors like age; P-value<0.001, OR=0.221 after controlling for potentially confounding factors like gender More... No biased transmission of any allele of any of the five eval...... No biased transmission of any allele of any of the five evaluated polymorphisms was observed for the entire sample of ADHD, ADHD-I, or ADHD-C. We only found biased transmission of these SNPs in the ADHD-HI subgroup. No association was found for ADHD females or subtypes. The results showed that there was no different genotype distribution of any SNP after controlling for potentially confounding factors including gender and age. More... Significant
Brookes K, 2006 A/G UNPHASED TDT P-value=0.0258 UNPHASED TDT P-value=0.0258 significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis Significant
Guan L, 2009 single SNP association analyses: Nominal P-value=0.012, Empi...... single SNP association analyses: Nominal P-value=0.012, Empirical P-value=0.017 for ADHD; Nominal P-value=0.018, Empirical P-value=0.034 for ADHD-I More... achieve nominal and empirical significance for ADHD and ADHD...... achieve nominal and empirical significance for ADHD and ADHD-I More... Significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Genes from other sources Help (count: 0)


SNPs in LD with rs2239448 (count: 34) View in gBrowse (chrX:43438662..43612708 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 34)