ADHDgene Database

Gene Report

Basic Info

Approved Symbol	PRDX6
Symbol Alias	AOP2, KIAA0106, 1-Cys, NSGPx, PRX, aiPLA2, MGC46173, p29
Approved Name	peroxiredoxin 6
Location	1q24.1
Position	chr1:173446405-173457946, +
External Links	HGNC: 16753 Entrez Gene: 9588 Ensembl: ENSG00000117592 UCSC: uc001giy.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.1	chr1:172900000-176000000	1 (1/0/0)

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49
GO:0004091	carboxylesterase activity	Molecular Function		40

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0009395	phospholipid catabolic process	Biological Process	IDA[10893423]	4
GO:0016023	cytoplasmic membrane-bounded vesicle	Cellular Component		16
GO:0016209	antioxidant activity	Molecular Function	NAS[10893423]	3
GO:0042744	hydrogen peroxide catabolic process	Biological Process		5
GO:0051920	peroxiredoxin activity	Molecular Function		2
GO:0004602	glutathione peroxidase activity	Molecular Function		5
GO:0004623	phospholipase A2 activity	Molecular Function	IDA[10893423]	10
GO:0005515	protein binding	Molecular Function	IPI[19188445]	910
GO:0005737	cytoplasm	Cellular Component	IDA[19188445]	690
GO:0005764	lysosome	Cellular Component		31
GO:0005829	cytosol	Cellular Component	NAS[9497358]	447
GO:0006979	response to oxidative stress	Biological Process	IDA[10893423]	17

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00360	Phenylalanine metabolism	8

Genes shared at least 5 GO terms with PRDX6 (count: 2)

Gene Symbol	Pathway Count	Pathway List
PRDX5	5	antioxidant activity; hydrogen peroxide catabolic process; peroxiredoxin activity; cytoplasm; response to oxidative stress;
PLA2G6	5	lipase activity; carboxylesterase activity; phospholipase A2 activity; cytoplasm; cytosol;

Genes shared at least 2 KEGG pathways with PRDX6 (count: 6)

Gene Symbol	Pathway Count	Pathway List
ALDH3A1	2	Metabolic pathways; Phenylalanine metabolism;
ALDH3B1	2	Metabolic pathways; Phenylalanine metabolism;
ALDH3B2	2	Metabolic pathways; Phenylalanine metabolism;
DDC	2	Metabolic pathways; Phenylalanine metabolism;
MAOA	2	Metabolic pathways; Phenylalanine metabolism;
MAOB	2	Metabolic pathways; Phenylalanine metabolism;

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Region: chr1:173446405..173457946 View in gBrowse