ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol DDC
Symbol Alias AADC
Approved Name dopa decarboxylase (aromatic L-amino acid decarboxylase)
Location 7p12.1
Position chr7:50526134-50633154, -1
External Links HGNC: 2719
Entrez Gene: 1644
Ensembl: ENSG00000132437
UCSC: uc003tpf.4
No. of Studies 6 (significant: 5; non-significant: 1; trend: 0)
Source Literature-origin; Mapped by Literature SNP

Gene related studies (count: 6)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Brookes K, 2006 UNPHASED TDT P-value=0.0386, global P-value=0.537, WHAP TDT P_sum P-value=0.78; OR=1.28, one or more SNPs with nominal P-value<0.05 located in this gene Significant
Hawi Z, 2001 haplotype containing allele 1 of the dopa gene and allele 10 of D7S2422, TRANSMIT P-value=0.025, X2=5; the result showed a significant association with ADHD Significant
Hawi Z, 2005 paternal versus maternal transmissions, 9 genes combined TDT P-value=0.0019, X2=9.6 (1df), OR=1.56; TDT P-value=0.0026, X2=9 when DDC was removed in sensitivity analysis Non-significant
Guan L, 2009 haplotype association analysis: Nominal P-value=0.031, Empirical P-value=0.26 for ADHD | Nominal P-value=0.006, Empirical P-value=0.052 for ADHD-I. 6 SNPs in this gene achieved nominal significance for ADHD/ADHD-I, and haplotype association test also achieved nominal significance for ADHD/ADHD-I. Significant
Ribases M, 2009(b) Haplotype analysis: P-value=0.00053, OR=2.17 for adult ADHD; P-value=0.0017, OR=1.90 for childhood ADHD. strongly associated with both adulthood and childhood ADHD. Significant
Kirley A, 2002 HHRR: P=0.1 (RR=1.24, OR=1.52); TDT: P=0.043 (OR=2); TDT by presence of family history: P=1 (OR[95%CI]=1.43[0.26-7.74]); TDT of Paternal and Maternal transmissions: P=0.411 (OR[95%CI]=1.8[0.44-7.31]). Increased transmission of the 4bp deletion in the untranslated exon 1 of DOPA was observed with marginal significance Significant

Gene related SNPs (count: 98)

Literature-origin SNPs (count: 10)

LD-proxies (count: 88)

Gene related CNVs (count: 0)

Gene related other variant (count: 3)

Gene related regions (count: 0)

Gene related GO terms (count: 25)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 25)

Gene related KEGG pathways (count: 5)

Genes shared at least 5 GO terms with DDC (count: 8)

Genes shared at least 2 KEGG pathways with DDC (count: 13)

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Region: chr7:50526134..50633154 View in gBrowse
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