ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs6592961 dbSNP Ensembl
Location	chr7:50572890(Fwd)
Variant Alleles	G/A
Ancestral Allele	A
Functional Annotation	intron_variant; NMD_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000357936; ENST00000380984; ENST00000426377; ENST00000430300; ENST00000431062; ENST00000444124; ENST00000444733) NMD_transcript_variant(ENST00000444733)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Ribases M, 2009(b)			Case-control test: lowest P-value=0.00067 for genotype analy...... Case-control test: lowest P-value=0.00067 for genotype analysis, P-value=0.0029 for allele analysis in all adult ADHD; lowest P-value=0.00059 for genotype analysis, P-value=0.0018 for allele analysis in adult combined ADHD. \| lowest P-value=1.90E-06 for genotype analysis, P-value=2.03E-05 for allele analysis in all childhood ADHD; lowest P-value=7.20E-05 for genotype analysis, P-value=0.00053 for allele analysis in childhood combined ADHD; lowest P-value=0.00061 for genotype analysis, P-value=0.0014 for allele analysis in childhood inattentive ADHD. More...	Still significant associated with all ADHD and combined ADHD...... Still significant associated with all ADHD and combined ADHD in adult and childhood groups after correcting for multiple comparisons, as well as in childhood inattentive ADHD group More...	Significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	7p12.1	6(5/1/0)

Genes from other sources (count: 0)

SNPs in LD with rs6592961 (count: 18) View in gBrowse (chr7:50544314..50615840 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 18)

rs_ID	Functional Annotation	r²[population]
rs17152020	intron_variant; NMD_transcript_variant; upstream_gene_variant	0.813[CEU]; 0.914[GIH]
rs3779084	intron_variant; NMD_transcript_variant	0.813[CEU]; 0.942[GIH]
rs4947584	intron_variant; NMD_transcript_variant	0.807[ASW]; 0.931[CHB]; 0.955[CHD]; 0.937[JPT]; 0.835[LWK]; 0.851[MKK]
rs7809758	intron_variant; NMD_transcript_variant	0.931[CHB]; 0.955[CHD]; 0.937[JPT]; 0.879[LWK]; 0.882[MKK]
rs3735274	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	0.869[CHB]; 0.908[CHD]
rs1817074	intron_variant; NMD_transcript_variant	0.857[CHB]; 0.937[JPT]; 0.926[YRI]
rs10249982	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.863[CHB]
rs4585697	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant	0.931[CHB]; 0.866[CHD]
rs4490786	intron_variant; nc_transcript_variant; NMD_transcript_variant; splice_region_variant	0.813[CEU]; 0.914[GIH]
rs12535064	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.869[CHB]; 0.861[CHD]
rs2198144	intron_variant; NMD_transcript_variant	0.931[CHB]; 0.937[JPT]; 0.887[YRI]
rs6592963	intron_variant; NMD_transcript_variant	0.931[CHB]; 0.866[CHD]
rs2100280	intron_variant; NMD_transcript_variant	0.931[CHB]; 0.866[CHD]
rs7808025	intron_variant; NMD_transcript_variant	1.0[CEU]; 0.961[TSI]; 0.866[ASW]; 1.0[CHB]; 0.908[CHD]; 1.0[JPT]; 0.952[MEX]
rs880028	intron_variant; NMD_transcript_variant	0.813[CEU]; 0.942[GIH]
rs10244632	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	0.869[CHB]
rs9918702	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.869[CHB]
rs12538830	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.869[CHB]; 0.866[CHD]