ADHDgene Database

Gene Report

Basic Info

Approved Symbol	AANAT
Symbol Alias	SNAT
Approved Name	aralkylamine N-acetyltransferase
Previous Name	arylalkylamine N-acetyltransferase
Name Alias	serotonin N-acetyltransferase
Location	17q25
Position	chr17:74449433-74466199, +
External Links	HGNC: 19 Entrez Gene: 15 Ensembl: ENSG00000129673 UCSC: uc002jro.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Chaste P, 2011	Several damaging mutations were found in patients with ADHD, but no significant enrichment compared with the general population.	Trend

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 3)

Variant Name	Variant Type	No. of Studies (significant/non-significant/trend)
AANAT_A163V	point mutation	1 (0/0/1)
AANAT_G177D	point mutation	1 (0/0/1)
AANAT_V62I	point mutation	1 (0/0/1)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005829	cytosol	Cellular Component		447
GO:0006474	N-terminal protein amino acid acetylation	Biological Process	IDA[11313340]	1
GO:0004059	aralkylamine N-acetyltransferase activity	Molecular Function	IDA[11313340]; NAS[8661026]	1
GO:0034641	cellular nitrogen compound metabolic process	Biological Process		30
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0007623	circadian rhythm	Biological Process	IMP[12736803]; NAS[8661026]	15
GO:0030187	melatonin biosynthetic process	Biological Process	IDA[11313340]; NAS[8661026]	2
GO:0071320	cellular response to cAMP	Biological Process	IDA[11313340]	5
GO:0046219	indolalkylamine biosynthetic process	Biological Process		5
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA[11313340]	87

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00380	Tryptophan metabolism	12
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with AANAT (count: 4)

Gene Symbol	Pathway Count	Pathway List
ASMT	5	cytosol; cellular nitrogen compound metabolic process; small molecule metabolic process; melatonin biosynthetic process; indolalkylamine biosynthetic process;
DDC	5	cytosol; cellular nitrogen compound metabolic process; small molecule metabolic process; circadian rhythm; indolalkylamine biosynthetic process;
TPH1	5	cytosol; cellular nitrogen compound metabolic process; small molecule metabolic process; circadian rhythm; indolalkylamine biosynthetic process;
TPH2	5	cytosol; cellular nitrogen compound metabolic process; small molecule metabolic process; circadian rhythm; indolalkylamine biosynthetic process;

Genes shared at least 2 KEGG pathways with AANAT (count: 11)

Gene Symbol	Pathway Count	Pathway List
ACAT1	2	Tryptophan metabolism; Metabolic pathways;
ALDH3A2	2	Tryptophan metabolism; Metabolic pathways;
ASMT	2	Tryptophan metabolism; Metabolic pathways;
DDC	2	Tryptophan metabolism; Metabolic pathways;
ECHS1	2	Tryptophan metabolism; Metabolic pathways;
HAAO	2	Tryptophan metabolism; Metabolic pathways;
MAOA	2	Tryptophan metabolism; Metabolic pathways;
MAOB	2	Tryptophan metabolism; Metabolic pathways;
TDO2	2	Tryptophan metabolism; Metabolic pathways;
TPH1	2	Tryptophan metabolism; Metabolic pathways;
TPH2	2	Tryptophan metabolism; Metabolic pathways;

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Region: chr17:74449433..74466199 View in gBrowse