ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol TPH1
Previous Symbol TPRH, TPH
Approved Name tryptophan hydroxylase 1
Previous Name "tryptophan hydroxylase (tryptophan 5-monooxygenase)"
Name Alias "tryptophan 5-monooxygenase"
Location 11p15.3-p14
Position chr11:18039111-18063973, -1
External Links HGNC: 12008
Entrez Gene: 7166
Ensembl: ENSG00000129167
UCSC: uc001mnp.2
No. of Studies 6 (significant: 2; non-significant: 4; trend: 0)
Source Literature-origin; Mapped by Literature SNP

Gene related studies (count: 6)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Johansson S, 2010 nine markers haplotype P-value=0.02, OR=0.74 Significant
Tang G, 2001 the data indicated that the TPH gene A218C polymorphism may not be a susceptibility factor of ADHD in the Chinese Han population Non-significant
Ribases M, 2009(b) little evidence of association with ADHD was found. Non-significant
Gizer IR, 2009 The present study does not support a relation between ADHD and this gene. Non-significant
Li J, 2006(c) haplotype 218A/-6526G to the ADHD probands was significantly decreased, P-value=0.034, X2 =4.4995; decreased transmission of haplotype 218A/-6526G emerged in families of probands with ADHD-C, P-value=0.022, X2 =5.253 Significant
Brookes K, 2006 UNPHASED TDT P-value=0.299, global P-value=0.884, WHAP TDT P_sum P-value=0.253, no SNP with nominal P-value<0.05 located in this gene Non-significant

Gene related SNPs (count: 26)

Literature-origin SNPs (count: 9)

LD-proxies (count: 17)


Gene related CNVs (count: 0)

Gene related other variant (count: 2)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)


Gene related KEGG pathways (count: 1)

Genes shared at least 5 GO terms with TPH1 (count: 5)

Genes shared at least 2 KEGG pathways with TPH1 (count: 0)

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Region: chr11:18039111..18063973 View in gBrowse
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