ADHDgene Database

Gene Report

Basic Info

Approved Symbol	TYR
Symbol Alias	OCAIA, OCA1A, OCA1
Approved Name	tyrosinase
Name Alias	"oculocutaneous albinism IA"
Location	11q14.3
Position	chr11:88910620-89028927, 1
External Links	HGNC: 12442 Entrez Gene: 7299 Ensembl: ENSG00000077498 UCSC: uc001pcs.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	molecular function	IPI[16162817]	1015
GO:0006726	eye pigment biosynthetic process	biological process	TAS[7704033]	2
GO:0033162	melanosome membrane	cellular component	IEA	4
GO:0005764	lysosome	cellular component	TAS[11092760]	34
GO:0006583	melanin biosynthetic process from tyrosine	biological process	TAS[7704033]	1
GO:0007601	visual perception	biological process	TAS[7704033]	29
GO:0005798	Golgi-associated vesicle	cellular component	TAS[10823941]	5
GO:0004503	monophenol monooxygenase activity	molecular function	IDA[11092760]	1
GO:0005737	cytoplasm	cellular component	IDA[11092760]	781
GO:0042803	protein homodimerization activity	molecular function	ISS	128
GO:0042470	melanosome	cellular component	ISS	22
GO:0048538	thymus development	biological process	IEA	15
GO:0016021	integral to membrane	cellular component	IEA	932
GO:0046982	protein heterodimerization activity	molecular function	ISS	73
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[11092760]	99
GO:0008283	cell proliferation	biological process	IEA	66
GO:0005507	copper ion binding	molecular function	IMP[11092760]	9

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene
hsa00350	Tyrosine metabolism	17
hsa00740	Riboflavin metabolism	5
hsa04916	Melanogenesis	18
hsa00950	Alkaloid biosynthesis I	2

Genes shared at least 5 GO terms with TYR (count: 5)

Gene Symbol	Pathway Count	Pathway List
OCA2	6	protein binding; eye pigment biosynthetic process; melanosome membrane; cytoplasm; integral to membrane; cell proliferation;
ALG2	5	protein binding; cytoplasm; integral to membrane; protein heterodimerization activity; perinuclear region of cytoplasm;
ERBB2	5	protein binding; integral to membrane; protein heterodimerization activity; perinuclear region of cytoplasm; cell proliferation;
TSC2	5	protein binding; cytoplasm; protein homodimerization activity; protein heterodimerization activity; perinuclear region of cytoplasm;
TPD52L1	5	protein binding; cytoplasm; protein homodimerization activity; protein heterodimerization activity; perinuclear region of cytoplasm;

Genes shared at least 2 KEGG pathways with TYR (count: 1)

Gene Symbol	Pathway Count	Pathway List
DDC	2	Tyrosine metabolism; Alkaloid biosynthesis I;

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Region: chr11:88910620..89028927 View in gBrowse