ADHDgene Database

Gene Report

Basic Info

Approved Symbol	AGXT2
Symbol Alias	AGT2
Approved Name	alanine--glyoxylate aminotransferase 2
Previous Name	alanine-glyoxylate aminotransferase 2
Name Alias	beta-alanine-pyruvate aminotransferase, "beta-ALAAT II"
Location	5p13
Position	chr5:34998206-35048240, -
External Links	HGNC: 14412 Entrez Gene: 64902 Ensembl: ENSG00000113492 UCSC: uc003jjf.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p13	chr5:28900000-42500000	3 (1/1/1)

Gene related GO terms (count: 16)

ID	Name	Type	No. of Genes in ADHDgene
GO:0047305	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity	Molecular Function	1
GO:0055086	nucleobase-containing small molecule metabolic process	Biological Process	9
GO:0044281	small molecule metabolic process	Biological Process	248
GO:0045429	positive regulation of nitric oxide biosynthetic process	Biological Process	6
GO:0046135	pyrimidine nucleoside catabolic process	Biological Process	3
GO:0046487	glyoxylate metabolic process	Biological Process	1
GO:0019265	glycine biosynthetic process, by transamination of glyoxylate	Biological Process	1
GO:0019481	L-alanine catabolic process, by transamination	Biological Process	1
GO:0030170	pyridoxal phosphate binding	Molecular Function	12
GO:0034641	cellular nitrogen compound metabolic process	Biological Process	30
GO:0006206	pyrimidine nucleobase metabolic process	Biological Process	3
GO:0008453	alanine-glyoxylate transaminase activity	Molecular Function	1
GO:0009436	glyoxylate catabolic process	Biological Process	1
GO:0016223	beta-alanine-pyruvate transaminase activity	Molecular Function	1
GO:0005759	mitochondrial matrix	Cellular Component	32
GO:0005739	mitochondrion	Cellular Component	183

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00260	Glycine, serine and threonine metabolism	6	Serine is derived from 3-phospho-D-glycerate, an intermediat...... Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018]. More...
hsa00250	Alanine, aspartate and glutamate metabolism	4

Genes shared at least 5 GO terms with AGXT2 (count: 1)

Gene Symbol	Pathway Count	Pathway List
NT5M	6	nucleobase-containing small molecule metabolic process; small molecule metabolic process; pyrimidine nucleoside catabolic process; pyrimidine nucleobase metabolic process; mitochondrial matrix; mitochondrion;

Genes shared at least 2 KEGG pathways with AGXT2 (count: 7)

Gene Symbol	Pathway Count	Pathway List
GFPT2	2	Metabolic pathways; Alanine, aspartate and glutamate metabolism;
GLUL	2	Metabolic pathways; Alanine, aspartate and glutamate metabolism;
MAOA	2	Metabolic pathways; Glycine, serine and threonine metabolism;
MAOB	2	Metabolic pathways; Glycine, serine and threonine metabolism;
SARDH	2	Metabolic pathways; Glycine, serine and threonine metabolism;
SHMT1	2	Metabolic pathways; Glycine, serine and threonine metabolism;
SHMT2	2	Metabolic pathways; Glycine, serine and threonine metabolism;

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Region: chr5:34998206..35048240 View in gBrowse