ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SHMT2
Previous Symbol	SHMT
Approved Name	serine hydroxymethyltransferase 2 (mitochondrial)
Location	12q12-q14
Position	chr12:57623356-57628718, +
External Links	HGNC: 10852 Entrez Gene: 6472 Ensembl: ENSG00000182199 UCSC: uc001snf.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2012]_16	chr12:55902280-55923860 (NCBI36 / hg18)	21581	12q13.3	Del

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003682	chromatin binding	Molecular Function	IDA[18063578]	48
GO:0005739	mitochondrion	Cellular Component		183
GO:0004372	glycine hydroxymethyltransferase activity	Molecular Function	IDA[8505317]	2
GO:0006730	one-carbon metabolic process	Biological Process	IDA[11516159]	9
GO:0008168	methyltransferase activity	Molecular Function		8
GO:0008284	positive regulation of cell proliferation	Biological Process		69
GO:0008732	L-allo-threonine aldolase activity	Molecular Function		2
GO:0005743	mitochondrial inner membrane	Cellular Component		44
GO:0005758	mitochondrial intermembrane space	Cellular Component		9
GO:0005759	mitochondrial matrix	Cellular Component		32
GO:0006564	L-serine biosynthetic process	Biological Process		1
GO:0035999	tetrahydrofolate interconversion	Biological Process		4
GO:0042645	mitochondrial nucleoid	Cellular Component	IDA[18063578]	1
GO:0042802	identical protein binding	Molecular Function		70
GO:0051289	protein homotetramerization	Biological Process		9
GO:0015630	microtubule cytoskeleton	Cellular Component		34
GO:0016597	amino acid binding	Molecular Function		8
GO:0019264	glycine biosynthetic process from serine	Biological Process		2
GO:0030170	pyridoxal phosphate binding	Molecular Function		12

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00670	One carbon pool by folate	6
hsa00260	Glycine, serine and threonine metabolism	6	Serine is derived from 3-phospho-D-glycerate, an intermediat...... Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018]. More...
hsa00460	Cyanoamino acid metabolism	4

Genes shared at least 5 GO terms with SHMT2 (count: 1)

Gene Symbol	Pathway Count	Pathway List
SHMT1	8	mitochondrion; glycine hydroxymethyltransferase activity; L-allo-threonine aldolase activity; tetrahydrofolate interconversion; protein homotetramerization; amino acid binding; glycine biosynthetic process from serine; pyridoxal phosphate binding;

Genes shared at least 2 KEGG pathways with SHMT2 (count: 10)

Gene Symbol	Pathway Count	Pathway List
SHMT1	4	Metabolic pathways; One carbon pool by folate; Glycine, serine and threonine metabolism; Cyanoamino acid metabolism;
AGXT2	2	Metabolic pathways; Glycine, serine and threonine metabolism;
ATIC	2	Metabolic pathways; One carbon pool by folate;
GGT1	2	Metabolic pathways; Cyanoamino acid metabolism;
GGT5	2	Metabolic pathways; Cyanoamino acid metabolism;
MAOA	2	Metabolic pathways; Glycine, serine and threonine metabolism;
MAOB	2	Metabolic pathways; Glycine, serine and threonine metabolism;
MTHFD2L	2	Metabolic pathways; One carbon pool by folate;
MTHFR	2	Metabolic pathways; One carbon pool by folate;
SARDH	2	Metabolic pathways; Glycine, serine and threonine metabolism;

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Region: chr12:57623356..57628718 View in gBrowse