ADHDgene Database

Gene Report

Basic Info

Approved Symbol	PRODH
Symbol Alias	HSPOX2, PRODH1, PIG6, PRODH2, TP53I6
Approved Name	proline dehydrogenase (oxidase) 1
Previous Name	"proline dehydrogenase (proline oxidase )"
Location	22q11.2
Position	chr22:18900294-18924066, -1
External Links	HGNC: 9453 Entrez Gene: 5625 Ensembl: ENSG00000100033 UCSC: uc002zok.4
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_40	chr22:17257787-19792353 (NCBI36 / hg18)	2534567	22q11.21	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005743	mitochondrial inner membrane	cellular component	TAS	55
GO:0004657	proline dehydrogenase activity	molecular function	IDA[15662599]	1
GO:0010133	proline catabolic process to glutamate	biological process	IEA	1
GO:0071949	FAD binding	molecular function	IDA[15662599]	1
GO:0005759	mitochondrial matrix	cellular component	IEA	39
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	biological process	NAS[9305847]	3
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	30
GO:0006537	glutamate biosynthetic process	biological process	IEA	2
GO:0019470	4-hydroxyproline catabolic process	biological process	TAS	1
GO:0006560	proline metabolic process	biological process	TAS[9385373]	1
GO:0006562	proline catabolic process	biological process	TAS	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00330	Arginine and proline metabolism	7

Genes shared at least 5 GO terms with PRODH (count: 0)

Genes shared at least 2 KEGG pathways with PRODH (count: 0)

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Region: chr22:18900294..18924066 View in gBrowse