ADHDgene Database

Gene Report

Basic Info

Approved Symbol	PRODH
Symbol Alias	HSPOX2, PRODH1, PIG6, PRODH2, TP53I6
Approved Name	proline dehydrogenase (oxidase) 1
Previous Name	proline dehydrogenase (proline oxidase )
Location	22q11.2
Position	chr22:18900294-18924066, -
External Links	HGNC: 9453 Entrez Gene: 5625 Ensembl: ENSG00000100033 UCSC: uc010grl.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_40	chr22:17257787-19792353 (NCBI36 / hg18)	2534567	22q11.21	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004657	proline dehydrogenase activity	Molecular Function	IDA[15662599]	1
GO:0005759	mitochondrial matrix	Cellular Component		32
GO:0005743	mitochondrial inner membrane	Cellular Component		44
GO:0006560	proline metabolic process	Biological Process	TAS[9385373]	1
GO:0006537	glutamate biosynthetic process	Biological Process		2
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	Biological Process	NAS[9305847]	2
GO:0006562	proline catabolic process	Biological Process		1
GO:0019470	4-hydroxyproline catabolic process	Biological Process		1
GO:0010133	proline catabolic process to glutamate	Biological Process		1
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0034641	cellular nitrogen compound metabolic process	Biological Process		30
GO:0071949	FAD binding	Molecular Function	IDA[15662599]	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00330	Arginine and proline metabolism	13

Genes shared at least 5 GO terms with PRODH (count: 0)

Genes shared at least 2 KEGG pathways with PRODH (count: 11)

Gene Symbol	Pathway Count	Pathway List
ALDH3A2	2	Metabolic pathways; Arginine and proline metabolism;
ARG1	2	Metabolic pathways; Arginine and proline metabolism;
CKMT1A	2	Metabolic pathways; Arginine and proline metabolism;
CKMT1B	2	Metabolic pathways; Arginine and proline metabolism;
GLUL	2	Metabolic pathways; Arginine and proline metabolism;
MAOA	2	Metabolic pathways; Arginine and proline metabolism;
MAOB	2	Metabolic pathways; Arginine and proline metabolism;
NOS1	2	Metabolic pathways; Arginine and proline metabolism;
ODC1	2	Metabolic pathways; Arginine and proline metabolism;
P4HA3	2	Metabolic pathways; Arginine and proline metabolism;
PYCRL	2	Metabolic pathways; Arginine and proline metabolism;

View in gBrowse

Region: chr22:18900294..18924066 View in gBrowse