ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CYP2E1
Previous Symbol	CYP2E
Approved Name	cytochrome P450, family 2, subfamily E, polypeptide 1
Previous Name	cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1
Location	10
Position	chr10:135340867-135374724, +
External Links	HGNC: 2631 Entrez Gene: 1571 Ensembl: ENSG00000130649 UCSC: uc001lnj.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_23	chr10:132453545-135284293 (NCBI36 / hg18)	2830749	10q26.3	del

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 25)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005506	iron ion binding	Molecular Function		20
GO:0005739	mitochondrion	Cellular Component		183
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0006641	triglyceride metabolic process	Biological Process		8
GO:0006805	xenobiotic metabolic process	Biological Process		25
GO:0008202	steroid metabolic process	Biological Process	IMP[18356043]	14
GO:0009055	electron carrier activity	Molecular Function		18
GO:0010193	response to ozone	Biological Process		3
GO:0000139	Golgi membrane	Cellular Component		95
GO:0004497	monooxygenase activity	Molecular Function	IDA[19651758]	2
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0042493	response to drug	Biological Process		68
GO:0031227	intrinsic to endoplasmic reticulum membrane	Cellular Component		5
GO:0020037	heme binding	Molecular Function	IDA[18818195]	23
GO:0055114	oxidation-reduction process	Biological Process	IDA[16401082]	15
GO:0046483	heterocycle metabolic process	Biological Process	IDA[19651758]	2
GO:0045471	response to ethanol	Biological Process		17
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Molecular Function	TAS[18818195]	1
GO:0016491	oxidoreductase activity	Molecular Function	IDA[16401082]	21
GO:0016098	monoterpenoid metabolic process	Biological Process	IDA[16401082]	1
GO:0010243	response to organic nitrogen	Biological Process		4
GO:0019899	enzyme binding	Molecular Function	IPI[15680923]	47
GO:0019825	oxygen binding	Molecular Function	TAS[3233219]	5
GO:0017144	drug metabolic process	Biological Process	IDA[19219744]; IMP[18356043]	7
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Molecular Function		1

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene
hsa01100	Metabolic pathways	237
hsa00591	Linoleic acid metabolism	10
hsa00590	Arachidonic acid metabolism	16
hsa00982	Drug metabolism - cytochrome P450	29
hsa00980	Metabolism of xenobiotics by cytochrome P450	26

Genes shared at least 5 GO terms with CYP2E1 (count: 10)

Gene Symbol	Pathway Count	Pathway List
UGT1A1	8	endoplasmic reticulum membrane; xenobiotic metabolic process; steroid metabolic process; small molecule metabolic process; response to drug; heterocycle metabolic process; enzyme binding; drug metabolic process;
CYP27A1	5	iron ion binding; xenobiotic metabolic process; electron carrier activity; small molecule metabolic process; heme binding;
FADS1	5	iron ion binding; endoplasmic reticulum membrane; small molecule metabolic process; heme binding; oxidoreductase activity;
SDHD	5	iron ion binding; mitochondrion; electron carrier activity; small molecule metabolic process; heme binding;
CYBA	5	mitochondrion; electron carrier activity; response to drug; heme binding; oxidation-reduction process;
NOX4	5	mitochondrion; endoplasmic reticulum membrane; electron carrier activity; heme binding; oxidation-reduction process;
TXN	5	mitochondrion; electron carrier activity; small molecule metabolic process; oxidation-reduction process; enzyme binding;
WWOX	5	mitochondrion; steroid metabolic process; oxidation-reduction process; oxidoreductase activity; enzyme binding;
UGT1A9	5	endoplasmic reticulum membrane; xenobiotic metabolic process; small molecule metabolic process; enzyme binding; drug metabolic process;
MAOB	5	xenobiotic metabolic process; electron carrier activity; small molecule metabolic process; response to drug; response to ethanol;

Genes shared at least 2 KEGG pathways with CYP2E1 (count: 40)

Gene Symbol	Pathway Count	Pathway List
ALDH3A1	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
ALDH3B1	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
ALDH3B2	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
PLA2G10	3	Metabolic pathways; Linoleic acid metabolism; Arachidonic acid metabolism;
PLA2G1B	3	Metabolic pathways; Linoleic acid metabolism; Arachidonic acid metabolism;
PLA2G2A	3	Metabolic pathways; Linoleic acid metabolism; Arachidonic acid metabolism;
PLA2G2D	3	Metabolic pathways; Linoleic acid metabolism; Arachidonic acid metabolism;
PLA2G2E	3	Metabolic pathways; Linoleic acid metabolism; Arachidonic acid metabolism;
PLA2G3	3	Metabolic pathways; Linoleic acid metabolism; Arachidonic acid metabolism;
PLA2G4B	3	Metabolic pathways; Linoleic acid metabolism; Arachidonic acid metabolism;
PLA2G5	3	Metabolic pathways; Linoleic acid metabolism; Arachidonic acid metabolism;
PLA2G6	3	Metabolic pathways; Linoleic acid metabolism; Arachidonic acid metabolism;
UGT1A1	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A10	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A3	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A4	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A5	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A6	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A7	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A8	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT1A9	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2A1	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2A2	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2A3	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2B10	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2B11	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2B15	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2B17	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2B28	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2B4	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
UGT2B7	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
GGT1	2	Metabolic pathways; Arachidonic acid metabolism;
GGT5	2	Metabolic pathways; Arachidonic acid metabolism;
LTC4S	2	Metabolic pathways; Arachidonic acid metabolism;
MAOA	2	Metabolic pathways; Drug metabolism - cytochrome P450;
MAOB	2	Metabolic pathways; Drug metabolism - cytochrome P450;
PTGS1	2	Metabolic pathways; Arachidonic acid metabolism;
GSTP1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
GSTT1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
GSTT2	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;

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Region: chr10:135340867..135374724 View in gBrowse