ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CXCR1
Previous Symbol	CMKAR1, IL8RA
Symbol Alias	CKR-1, CDw128a, CD181
Approved Name	chemokine (C-X-C motif) receptor 1
Previous Name	interleukin 8 receptor, alpha
Location	2q35
Position	chr2:219027568-219031718, -
External Links	HGNC: 6026 Entrez Gene: 3577 Ensembl: ENSG00000163464 UCSC: uc002vhc.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0070098	chemokine-mediated signaling pathway	Biological Process	TAS[1840701]	3
GO:0031623	receptor internalization	Biological Process	IDA[10734056]	10
GO:0038112	interleukin-8-mediated signaling pathway	Biological Process	IDA[10734056]	2
GO:0016021	integral to membrane	Cellular Component		845
GO:0019959	interleukin-8 binding	Molecular Function	IPI[11564821]	2
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[8381837]	72
GO:0016020	membrane	Cellular Component	TAS[10725748]	139
GO:0004918	interleukin-8 receptor activity	Molecular Function	IDA[10734056]	2
GO:0002407	dendritic cell chemotaxis	Biological Process	TAS[16621978]	5
GO:0004950	chemokine receptor activity	Molecular Function	TAS[1840701]	2
GO:0004930	G-protein coupled receptor activity	Molecular Function	TAS[8381837]	236
GO:0006935	chemotaxis	Biological Process	TAS[10725748]	15
GO:0005886	plasma membrane	Cellular Component		772
GO:0007166	cell surface receptor signaling pathway	Biological Process	IDA[10734056]	35
GO:0006954	inflammatory response	Biological Process	TAS[10725748]	51

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04144	Endocytosis	39	Endocytosis is a mechanism for cells to remove ligands, nutr...... Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type. More...
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	16	Two major virulence factors of H. pylori are the vacuolating...... Two major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA). More...
hsa04062	Chemokine signaling pathway	32	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. More...
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...

Genes shared at least 5 GO terms with CXCR1 (count: 4)

Gene Symbol	Pathway Count	Pathway List
CXCR2	10	receptor internalization; interleukin-8-mediated signaling pathway; interleukin-8 binding; membrane; interleukin-8 receptor activity; dendritic cell chemotaxis; chemotaxis; plasma membrane; cell surface receptor signaling pathway; inflammatory response;
CCR5	8	chemokine-mediated signaling pathway; G-protein coupled receptor signaling pathway; dendritic cell chemotaxis; chemokine receptor activity; chemotaxis; plasma membrane; cell surface receptor signaling pathway; inflammatory response;
C3AR1	5	G-protein coupled receptor signaling pathway; G-protein coupled receptor activity; chemotaxis; plasma membrane; inflammatory response;
PIK3CG	5	G-protein coupled receptor signaling pathway; membrane; dendritic cell chemotaxis; plasma membrane; inflammatory response;

Genes shared at least 2 KEGG pathways with CXCR1 (count: 14)

Gene Symbol	Pathway Count	Pathway List
CXCR2	4	Endocytosis; Epithelial cell signaling in Helicobacter pylori infection; Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CCR5	3	Endocytosis; Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
ADRBK1	2	Endocytosis; Chemokine signaling pathway;
ADRBK2	2	Endocytosis; Chemokine signaling pathway;
ARRB1	2	Endocytosis; Chemokine signaling pathway;
ARRB2	2	Endocytosis; Chemokine signaling pathway;
GIT1	2	Endocytosis; Epithelial cell signaling in Helicobacter pylori infection;
TGFBR1	2	Endocytosis; Cytokine-cytokine receptor interaction;
PAK1	2	Epithelial cell signaling in Helicobacter pylori infection; Chemokine signaling pathway;
RELA	2	Epithelial cell signaling in Helicobacter pylori infection; Chemokine signaling pathway;
CCL19	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CCL27	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCL12	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCR5	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;

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Region: chr2:219027568..219031718 View in gBrowse