Gene Report
Basic Info
Approved Symbol |
CXCR1
|
Previous Symbol |
CMKAR1, IL8RA |
Symbol Alias |
CKR-1, CDw128a, CD181 |
Approved Name |
chemokine (C-X-C motif) receptor 1 |
Previous Name |
interleukin 8 receptor, alpha |
Location |
2q35 |
Position |
chr2:219027568-219031718, - |
External Links |
HGNC: 6026
Entrez Gene: 3577
Ensembl: ENSG00000163464
UCSC: uc002vhc.2
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 15)
Gene related KEGG pathways (count: 4)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04144 |
Endocytosis |
39 |
Endocytosis is a mechanism for cells to remove ligands, nutr......
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
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|
hsa05120 |
Epithelial cell signaling in Helicobacter pylori infection |
16 |
Two major virulence factors of H. pylori are the vacuolating......
Two major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA).
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|
hsa04062 |
Chemokine signaling pathway |
32 |
Inflammatory immune response requires the recruitment of leu......
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
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|
hsa04060 |
Cytokine-cytokine receptor interaction |
38 |
Cytokines are soluble extracellular proteins or glycoprotein......
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
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|
Genes shared at least 5 GO terms with CXCR1 (count: 4)
Genes shared at least 2 KEGG pathways with CXCR1 (count: 14)
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