ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CXCR5
Previous Symbol	BLR1
Symbol Alias	MDR15, CD185
Approved Name	chemokine (C-X-C motif) receptor 5
Previous Name	Burkitt lymphoma receptor 1, GTP-binding protein, "Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)"
Location	11q23.3
Position	chr11:118754475-118768508, +
External Links	HGNC: 1060 Entrez Gene: 643 Ensembl: ENSG00000160683 UCSC: uc001pue.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016494	C-X-C chemokine receptor activity	Molecular Function		2
GO:0042113	B cell activation	Biological Process		5
GO:0048535	lymph node development	Biological Process		3
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component	TAS[1425907]	220
GO:0006928	cellular component movement	Biological Process	TAS[1425907]	16
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[1425907]	72
GO:0004930	G-protein coupled receptor activity	Molecular Function	TAS[1425907]	236

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04062	Chemokine signaling pathway	32	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. More...
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...

Genes shared at least 5 GO terms with CXCR5 (count: 0)

Genes shared at least 2 KEGG pathways with CXCR5 (count: 6)

Gene Symbol	Pathway Count	Pathway List
CCL19	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CCL27	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CCR5	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCL12	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCR1	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCR2	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;

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Region: chr11:118754475..118768508 View in gBrowse