ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CCL27
Previous Symbol	SCYA27
Symbol Alias	ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK
Approved Name	chemokine (C-C motif) ligand 27
Previous Name	small inducible cytokine subfamily A (Cys-Cys), member 27
Name Alias	CC chemokine ILC, "IL-11 Ralpha-locus chemokine", "cutaneous T-cell attracting chemokine"
Location	9p13
Position	chr9:34661893-34662689, -
External Links	HGNC: 10626 Entrez Gene: 10850 Ensembl: ENSG00000213927 UCSC: uc003zvm.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 0)

LD-proxies (count: 1)

rs_ID	Location	Functional Annotation
rs13299387	Chr9:34669005(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 6)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006935	chemotaxis	Biological Process	TAS[10588729]	15
GO:0006955	immune response	Biological Process		45
GO:0005576	extracellular region	Cellular Component		240
GO:0005615	extracellular space	Cellular Component		126
GO:0007267	cell-cell signaling	Biological Process	TAS[10588729]	38
GO:0008009	chemokine activity	Molecular Function		4

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04062	Chemokine signaling pathway	32	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. More...
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...
hsa04672	Intestinal immune network for IgA production	5	The intestine is the largest lymphoid tissue in the body. On...... The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes. More...

Genes shared at least 5 GO terms with CCL27 (count: 1)

Gene Symbol	Pathway Count	Pathway List
CXCL12	5	chemotaxis; immune response; extracellular region; extracellular space; chemokine activity;

Genes shared at least 2 KEGG pathways with CCL27 (count: 8)

Gene Symbol	Pathway Count	Pathway List
CXCL12	3	Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production;
CCL19	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CCR5	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCR1	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCR2	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCR5	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
IL6	2	Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production;
TNFRSF13B	2	Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production;

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Region: chr9:34661893..34662689 View in gBrowse