ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	USP2
Symbol Alias	UBP41
Approved Name	ubiquitin specific peptidase 2
Previous Name	ubiquitin specific protease 2
Location	11q23.3
Position	chr11:119225925-119252436, -
External Links	HGNC: 12618 Entrez Gene: 9099 Ensembl: ENSG00000036672 UCSC: uc001pwm.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004221	ubiquitin thiolesterase activity	Molecular Function	IDA[17290220]; IMP[19917254]	12
GO:0004197	cysteine-type endopeptidase activity	Molecular Function	TAS[9827704]	17
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IMP[17290220]	78
GO:0005938	cell cortex	Cellular Component		26
GO:0005813	centrosome	Cellular Component		71
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[16189514]	910
GO:0050821	protein stabilization	Biological Process	IDA[17290220]; IMP[19838211]	10
GO:0046872	metal ion binding	Molecular Function		170
GO:0048471	perinuclear region of cytoplasm	Cellular Component		87
GO:0048642	negative regulation of skeletal muscle tissue development	Biological Process		1
GO:0048643	positive regulation of skeletal muscle tissue development	Biological Process		2
GO:0030332	cyclin binding	Molecular Function	IPI[19917254]	4
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI[17290220]	23
GO:0042802	identical protein binding	Molecular Function		70
GO:0045931	positive regulation of mitotic cell cycle	Biological Process	IMP[17290220]	5
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process		25
GO:0007049	cell cycle	Biological Process		31
GO:0007517	muscle organ development	Biological Process		16
GO:0016579	protein deubiquitination	Biological Process	IDA[19917254]	6

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with USP2 (count: 12)

Gene Symbol	Pathway Count	Pathway List
USP10	6	ubiquitin thiolesterase activity; cysteine-type endopeptidase activity; nucleus; protein binding; ubiquitin-dependent protein catabolic process; protein deubiquitination;
USP22	6	ubiquitin thiolesterase activity; protein binding; positive regulation of mitotic cell cycle; ubiquitin-dependent protein catabolic process; cell cycle; protein deubiquitination;
PAFAH1B1	6	cell cortex; centrosome; nucleus; protein binding; perinuclear region of cytoplasm; positive regulation of mitotic cell cycle;
TNFAIP3	5	ubiquitin thiolesterase activity; centrosome; nucleus; protein binding; protein deubiquitination;
USP28	5	ubiquitin thiolesterase activity; nucleus; protein binding; ubiquitin-dependent protein catabolic process; protein deubiquitination;
USP37	5	ubiquitin thiolesterase activity; cysteine-type endopeptidase activity; nucleus; protein binding; ubiquitin-dependent protein catabolic process;
KAT5	5	negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; metal ion binding; perinuclear region of cytoplasm;
PDE2A	5	negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; metal ion binding; perinuclear region of cytoplasm;
PRKD1	5	cell cortex; nucleus; protein binding; metal ion binding; identical protein binding;
SNCA	5	cell cortex; nucleus; protein binding; perinuclear region of cytoplasm; identical protein binding;
GSK3B	5	centrosome; nucleus; protein binding; perinuclear region of cytoplasm; ubiquitin protein ligase binding;
PARK2	5	nucleus; protein binding; perinuclear region of cytoplasm; ubiquitin protein ligase binding; ubiquitin-dependent protein catabolic process;

Genes shared at least 2 KEGG pathways with USP2 (count: 0)

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Region: chr11:119225925..119252436 View in gBrowse