ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	USP28
Symbol Alias	KIAA1515
Approved Name	ubiquitin specific peptidase 28
Previous Name	ubiquitin specific protease 28
Location	11q23
Position	chr11:113668597-113746256, -
External Links	HGNC: 12625 Entrez Gene: 57646 Ensembl: ENSG00000048028 UCSC: uc001poh.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0043234	protein complex	Cellular Component	IDA[17873522]	45
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Biological Process	IDA[16901786]	4
GO:0034644	cellular response to UV	Biological Process	IDA[17873522]	5
GO:0010212	response to ionizing radiation	Biological Process	IDA[16901786]	5
GO:0016579	protein deubiquitination	Biological Process	IDA[17558397]	6
GO:0006974	response to DNA damage stimulus	Biological Process	IDA[17873522]	37
GO:0008283	cell proliferation	Biological Process	IMP[17558397]	60
GO:0006281	DNA repair	Biological Process		62
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process		25
GO:0005654	nucleoplasm	Cellular Component	IDA[17558397]	183
GO:0005730	nucleolus	Cellular Component		243
GO:0005515	protein binding	Molecular Function	IPI[17873522]	910
GO:0005634	nucleus	Cellular Component		770
GO:0004221	ubiquitin thiolesterase activity	Molecular Function	IMP[17558397]	12
GO:0004843	ubiquitin-specific protease activity	Molecular Function	IDA[17558397]	9
GO:0000077	DNA damage checkpoint	Biological Process	IMP[18662541]	7

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with USP28 (count: 29)

Gene Symbol	Pathway Count	Pathway List
MEN1	7	protein complex; response to DNA damage stimulus; DNA repair; nucleoplasm; nucleolus; protein binding; nucleus;
H2AFX	7	response to ionizing radiation; response to DNA damage stimulus; DNA repair; nucleoplasm; protein binding; nucleus; DNA damage checkpoint;
USP10	7	protein deubiquitination; DNA repair; ubiquitin-dependent protein catabolic process; protein binding; nucleus; ubiquitin thiolesterase activity; ubiquitin-specific protease activity;
MRE11A	7	response to DNA damage stimulus; cell proliferation; DNA repair; nucleoplasm; nucleolus; protein binding; nucleus;
RAD1	7	response to DNA damage stimulus; DNA repair; nucleoplasm; nucleolus; protein binding; nucleus; DNA damage checkpoint;
RAD9A	7	response to DNA damage stimulus; DNA repair; nucleoplasm; nucleolus; protein binding; nucleus; DNA damage checkpoint;
ERCC8	6	protein complex; response to DNA damage stimulus; DNA repair; nucleoplasm; protein binding; nucleus;
MAPK1	6	protein complex; response to DNA damage stimulus; nucleoplasm; nucleolus; protein binding; nucleus;
CHEK1	6	response to DNA damage stimulus; DNA repair; nucleoplasm; protein binding; nucleus; DNA damage checkpoint;
NCOA6	6	response to DNA damage stimulus; DNA repair; nucleoplasm; nucleolus; protein binding; nucleus;
XRCC5	6	cell proliferation; DNA repair; nucleoplasm; nucleolus; protein binding; nucleus;
HINFP	6	DNA repair; nucleoplasm; nucleolus; protein binding; nucleus; DNA damage checkpoint;
SNW1	5	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; nucleoplasm; nucleolus; protein binding; nucleus;
ATM	5	response to ionizing radiation; response to DNA damage stimulus; DNA repair; nucleoplasm; protein binding;
TNFAIP3	5	protein deubiquitination; protein binding; nucleus; ubiquitin thiolesterase activity; ubiquitin-specific protease activity;
USP2	5	protein deubiquitination; ubiquitin-dependent protein catabolic process; protein binding; nucleus; ubiquitin thiolesterase activity;
USP22	5	protein deubiquitination; ubiquitin-dependent protein catabolic process; protein binding; ubiquitin thiolesterase activity; ubiquitin-specific protease activity;
USP46	5	protein deubiquitination; ubiquitin-dependent protein catabolic process; protein binding; ubiquitin thiolesterase activity; ubiquitin-specific protease activity;
CHD1L	5	response to DNA damage stimulus; DNA repair; nucleolus; protein binding; nucleus;
MAPK3	5	response to DNA damage stimulus; nucleoplasm; nucleolus; protein binding; nucleus;
TP53BP1	5	response to DNA damage stimulus; DNA repair; nucleoplasm; protein binding; nucleus;
TRIP12	5	response to DNA damage stimulus; DNA repair; nucleoplasm; protein binding; nucleus;
YAP1	5	response to DNA damage stimulus; cell proliferation; nucleoplasm; protein binding; nucleus;
FEN1	5	DNA repair; nucleoplasm; nucleolus; protein binding; nucleus;
POLD3	5	DNA repair; nucleoplasm; nucleolus; protein binding; nucleus;
RAD23B	5	DNA repair; nucleoplasm; nucleolus; protein binding; nucleus;
SMC1A	5	DNA repair; nucleoplasm; nucleolus; protein binding; nucleus;
SSRP1	5	DNA repair; nucleoplasm; nucleolus; protein binding; nucleus;
USP37	5	ubiquitin-dependent protein catabolic process; protein binding; nucleus; ubiquitin thiolesterase activity; ubiquitin-specific protease activity;

Genes shared at least 2 KEGG pathways with USP28 (count: 0)

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Region: chr11:113668597..113746256 View in gBrowse