ADHDgene Database

Gene Report

Basic Info

Approved Symbol	AIFM3
Symbol Alias	AIFL, FLJ30473
Approved Name	apoptosis-inducing factor, mitochondrion-associated, 3
Location	22q11.21
Position	chr22:21319396-21335649, +
External Links	HGNC: 26398 Entrez Gene: 150209 Ensembl: ENSG00000183773
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 3)

ID	Location	Size	Band	Type
CNV_Jarick[2012]_41	chr22:17616020-19792353 (NCBI36 / hg18)	2176334	22q11.21	dup
CNV_Jarick[2012]_42	chr22:19066315-19792353 (NCBI36 / hg18)	726039	22q11.21	dup
CNV_Jarick[2012]_40	chr22:17257787-19792353 (NCBI36 / hg18)	2534567	22q11.21	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0050660	flavin adenine dinucleotide binding	Molecular Function		11
GO:0046872	metal ion binding	Molecular Function		170
GO:0051882	mitochondrial depolarization	Biological Process	IDA[15764604]	1
GO:0051537	2 iron, 2 sulfur cluster binding	Molecular Function		3
GO:0045454	cell redox homeostasis	Biological Process		13
GO:0022900	electron transport chain	Biological Process		12
GO:0016491	oxidoreductase activity	Molecular Function		21
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	Molecular Function	IDA[15764604]	7
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	Biological Process	IDA[15764604]	2
GO:0006917	induction of apoptosis	Biological Process	IDA[15764604]	31
GO:0005886	plasma membrane	Cellular Component	IDA[15764604]	772
GO:0005829	cytosol	Cellular Component	IDA[15764604]	447
GO:0005783	endoplasmic reticulum	Cellular Component	IDA[15764604]	100
GO:0005743	mitochondrial inner membrane	Cellular Component	IDA[15764604]	44
GO:0005739	mitochondrion	Cellular Component		183
GO:0005737	cytoplasm	Cellular Component		690
GO:0005634	nucleus	Cellular Component	IDA[15764604]	770

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with AIFM3 (count: 12)

Gene Symbol	Pathway Count	Pathway List
WWOX	7	oxidoreductase activity; induction of apoptosis; plasma membrane; cytosol; mitochondrion; cytoplasm; nucleus;
PYCARD	7	cysteine-type endopeptidase activator activity involved in apoptotic process; induction of apoptosis; cytosol; endoplasmic reticulum; mitochondrion; cytoplasm; nucleus;
CRYAB	6	metal ion binding; plasma membrane; cytosol; mitochondrion; cytoplasm; nucleus;
KARS	6	metal ion binding; plasma membrane; cytosol; mitochondrion; cytoplasm; nucleus;
PDE2A	6	metal ion binding; plasma membrane; cytosol; endoplasmic reticulum; cytoplasm; nucleus;
SNCA	6	oxidoreductase activity; plasma membrane; cytosol; mitochondrion; cytoplasm; nucleus;
PRKD1	5	metal ion binding; plasma membrane; cytosol; cytoplasm; nucleus;
STEAP2	5	metal ion binding; electron transport chain; oxidoreductase activity; plasma membrane; cytosol;
MAPK1	5	induction of apoptosis; cytosol; mitochondrion; cytoplasm; nucleus;
PERP	5	induction of apoptosis; plasma membrane; mitochondrion; cytoplasm; nucleus;
NCK1	5	plasma membrane; cytosol; endoplasmic reticulum; cytoplasm; nucleus;
PARK2	5	cytosol; endoplasmic reticulum; mitochondrion; cytoplasm; nucleus;

Genes shared at least 2 KEGG pathways with AIFM3 (count: 0)

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Region: chr22:21319396..21335649 View in gBrowse