ADHDgene Database

Gene Report

Basic Info

Approved Symbol	PTGS1
Symbol Alias	COX1, PGHS-1, PTGHS
Approved Name	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Location	9q32-q33.3
Position	chr9:125133229-125157982, +
External Links	HGNC: 9604 Entrez Gene: 5742 Ensembl: ENSG00000095303 UCSC: uc004bmg.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q33	chr9:117700000-130300000	2 (1/1/0)

Gene related GO terms (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0042127	regulation of cell proliferation	Biological Process		20
GO:0043231	intracellular membrane-bounded organelle	Cellular Component		62
GO:0019371	cyclooxygenase pathway	Biological Process	IDA[1380156]	1
GO:0020037	heme binding	Molecular Function		23
GO:0008217	regulation of blood pressure	Biological Process		8
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Molecular Function		11
GO:0006805	xenobiotic metabolic process	Biological Process		25
GO:0006979	response to oxidative stress	Biological Process		17
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0006629	lipid metabolic process	Biological Process	NAS[1907252]	51
GO:0005634	nucleus	Cellular Component		770
GO:0005737	cytoplasm	Cellular Component		690
GO:0004601	peroxidase activity	Molecular Function		4
GO:0004666	prostaglandin-endoperoxide synthase activity	Molecular Function	IDA[1380156]	1
GO:0001516	prostaglandin biosynthetic process	Biological Process		3
GO:0001750	photoreceptor outer segment	Cellular Component		8
GO:0046872	metal ion binding	Molecular Function		170
GO:0044444	cytoplasmic part	Cellular Component	IDA[12355421]	4
GO:0044281	small molecule metabolic process	Biological Process		248

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00590	Arachidonic acid metabolism	16

Genes shared at least 5 GO terms with PTGS1 (count: 3)

Gene Symbol	Pathway Count	Pathway List
FADS1	5	intracellular membrane-bounded organelle; heme binding; endoplasmic reticulum membrane; nucleus; small molecule metabolic process;
PRDX5	5	intracellular membrane-bounded organelle; response to oxidative stress; nucleus; cytoplasm; peroxidase activity;
PPP1CA	5	lipid metabolic process; nucleus; cytoplasm; metal ion binding; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with PTGS1 (count: 13)

Gene Symbol	Pathway Count	Pathway List
CYP2E1	2	Metabolic pathways; Arachidonic acid metabolism;
GGT1	2	Metabolic pathways; Arachidonic acid metabolism;
GGT5	2	Metabolic pathways; Arachidonic acid metabolism;
LTC4S	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G10	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G1B	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G2A	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G2D	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G2E	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G3	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G4B	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G5	2	Metabolic pathways; Arachidonic acid metabolism;
PLA2G6	2	Metabolic pathways; Arachidonic acid metabolism;

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Region: chr9:125133229..125157982 View in gBrowse