ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PNLIP
Approved Name	pancreatic lipase
Location	10q25.3
Position	chr10:118305428-118327367, +
External Links	HGNC: 9155 Entrez Gene: 5406 Ensembl: ENSG00000175535 UCSC: uc001lcm.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004091	carboxylesterase activity	Molecular Function		40
GO:0016298	lipase activity	Molecular Function		49

GO terms by database search (count: 11)

ID	Name	Type	No. of Genes in ADHDgene
GO:0004806	triglyceride lipase activity	Molecular Function	10
GO:0001523	retinoid metabolic process	Biological Process	2
GO:0016042	lipid catabolic process	Biological Process	32
GO:0008202	steroid metabolic process	Biological Process	14
GO:0006629	lipid metabolic process	Biological Process	51
GO:0005576	extracellular region	Cellular Component	240
GO:0046872	metal ion binding	Molecular Function	170
GO:0050253	retinyl-palmitate esterase activity	Molecular Function	9
GO:0030299	intestinal cholesterol absorption	Biological Process	1
GO:0044241	lipid digestion	Biological Process	2
GO:0044281	small molecule metabolic process	Biological Process	248

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04972	Pancreatic secretion	30	The pancreas performs both exocrine and endocrine functions....... The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion. More...
hsa01100	Metabolic pathways	237
hsa00561	Glycerolipid metabolism	15
hsa04975	Fat digestion and absorption	19	Fat is an important energy source from food. More than 95% o...... Fat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, dietary TAG is hydrolyzed to fatty acids (FA) and monoacylglycerols (MAG) by pancreatic lipase. These products are then emulsified with the help of phospholipids (PL) and bile acids (BA) present in bile to form micelles. Free FAs and MAGs are taken up by the enterocyte where they are rapidly resynthesized in endoplasmic reticulum (ER) to form TAG. PLs from the diet as well as bile - mainly LPA - too are absorbed by the enterocyte and are acylated to form phosphatidic acid (PA), which is also converted into TAG. Absorbed cholesterol (CL) is acylated to cholesterol esters (CE). Within the ER, TAG joins CE and apolipoprotein B (ApoB) to form chylomicrons that enter circulation through the lymph. More...
hsa04977	Vitamin digestion and absorption	7	Vitamins are a diverse and chemically unrelated group of org...... Vitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactions. Because humans and other mammals cannot synthesize these compounds (except for some synthesis of niacin), they must obtain them from exogenous sources via intestinal absorption. Vitamins are classified based on their solubility in water or fat. Most of the water-soluble vitamins are transported across the small intestinal membrane by carrier-mediated mechanisms, but vitamin B12, cobalamin, is transported by a receptor-mediated mechanism. Intestinal absorption of fat-soluble vitamins requires all of the processes needed for fat absorption. After digestion, these vitamins and the products of pancreatic hydrolysis of triglycerides (TG) are emulsified by bile salts to form mixed micelles which are taken up by intestinal enterocytes and incorporated into chylomicrons (CM). CM are then secreted into the lymphatic system, and finally moves into the plasma. More...

Genes shared at least 5 GO terms with PNLIP (count: 15)

Gene Symbol	Pathway Count	Pathway List
PNLIPRP2	8	triglyceride lipase activity; carboxylesterase activity; lipid metabolic process; extracellular region; retinyl-palmitate esterase activity; lipase activity; lipid digestion; small molecule metabolic process;
LIPE	6	triglyceride lipase activity; carboxylesterase activity; lipid catabolic process; lipid metabolic process; lipase activity; small molecule metabolic process;
LIPF	6	triglyceride lipase activity; carboxylesterase activity; lipid catabolic process; extracellular region; retinyl-palmitate esterase activity; lipase activity;
LPL	6	triglyceride lipase activity; carboxylesterase activity; lipid metabolic process; extracellular region; lipase activity; small molecule metabolic process;
APOC2	6	carboxylesterase activity; lipid catabolic process; lipid metabolic process; extracellular region; lipase activity; small molecule metabolic process;
LIPG	5	triglyceride lipase activity; carboxylesterase activity; lipid metabolic process; retinyl-palmitate esterase activity; lipase activity;
PNLIPRP1	5	triglyceride lipase activity; carboxylesterase activity; lipid metabolic process; extracellular region; lipase activity;
PNPLA3	5	triglyceride lipase activity; carboxylesterase activity; retinyl-palmitate esterase activity; lipase activity; small molecule metabolic process;
PLA1A	5	carboxylesterase activity; lipid catabolic process; lipid metabolic process; extracellular region; lipase activity;
PLA2G10	5	carboxylesterase activity; lipid catabolic process; extracellular region; lipase activity; small molecule metabolic process;
PLA2G2A	5	carboxylesterase activity; lipid catabolic process; extracellular region; lipase activity; small molecule metabolic process;
PLA2G2D	5	carboxylesterase activity; lipid catabolic process; extracellular region; lipase activity; small molecule metabolic process;
PLA2G2E	5	carboxylesterase activity; lipid catabolic process; extracellular region; lipase activity; small molecule metabolic process;
PLA2G3	5	carboxylesterase activity; lipid catabolic process; extracellular region; lipase activity; small molecule metabolic process;
PLA2G5	5	carboxylesterase activity; lipid catabolic process; extracellular region; lipase activity; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with PNLIP (count: 27)

Gene Symbol	Pathway Count	Pathway List
PNLIPRP1	4	Pancreatic secretion; Metabolic pathways; Glycerolipid metabolism; Fat digestion and absorption;
PNLIPRP2	4	Pancreatic secretion; Metabolic pathways; Glycerolipid metabolism; Fat digestion and absorption;
PLA2G10	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
PLA2G1B	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
PLA2G2A	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
PLA2G2D	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
PLA2G2E	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
PLA2G3	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
PLA2G4B	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
PLA2G5	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
PLA2G6	3	Pancreatic secretion; Metabolic pathways; Fat digestion and absorption;
DGAT2	3	Metabolic pathways; Glycerolipid metabolism; Fat digestion and absorption;
LIPF	3	Metabolic pathways; Glycerolipid metabolism; Fat digestion and absorption;
PLCB2	2	Pancreatic secretion; Metabolic pathways;
PLCB3	2	Pancreatic secretion; Metabolic pathways;
ALDH3A2	2	Metabolic pathways; Glycerolipid metabolism;
DAK	2	Metabolic pathways; Glycerolipid metabolism;
DGKH	2	Metabolic pathways; Glycerolipid metabolism;
GPAT2	2	Metabolic pathways; Glycerolipid metabolism;
LIPG	2	Metabolic pathways; Glycerolipid metabolism;
MBOAT1	2	Metabolic pathways; Glycerolipid metabolism;
MBOAT2	2	Metabolic pathways; Glycerolipid metabolism;
MGLL	2	Metabolic pathways; Glycerolipid metabolism;
PNPLA3	2	Metabolic pathways; Glycerolipid metabolism;
APOA1	2	Fat digestion and absorption; Vitamin digestion and absorption;
APOA4	2	Fat digestion and absorption; Vitamin digestion and absorption;
SCARB1	2	Fat digestion and absorption; Vitamin digestion and absorption;

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Region: chr10:118305428..118327367 View in gBrowse