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KEGG Pathway Report
Basic Info
| ID | hsa04370 |
|---|---|
| Name | VEGF signaling pathway |
| Description | There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma;PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3' -kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling. |
| No. of Genes in ADHDgene | 19 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 19)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| VEGFA | vascular endothelial growth factor A | 6p12 | 1(0/1/0) |
Genes from other sources (count: 18)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| PRKCB | protein kinase C, beta | 16p12 | Mapped by significant region |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 1p35 | Mapped by PBA pathway |
| PLA2G1B | phospholipase A2, group IB (pancreas) | 12q23-qter | Mapped by PBA pathway |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 14q11.2 | Mapped by significant region |
| PLA2G2E | phospholipase A2, group IIE | 1p36.13 | Mapped by PBA pathway |
| PLA2G2D | phospholipase A2, group IID | 1p36.12 | Mapped by PBA pathway |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| PLA2G4B | phospholipase A2, group IVB (cytosolic) | 15q11.2-q21.3 | Mapped by PBA pathway |
| PLA2G3 | phospholipase A2, group III | 22q12.2 | Mapped by PBA pathway |
| PLA2G5 | phospholipase A2, group V | 1p36-p34 | Mapped by PBA pathway |
| PLA2G6 | phospholipase A2, group VI (cytosolic, calcium-independent) | 22q13.1 | Mapped by PBA pathway |
| PLA2G10 | phospholipase A2, group X | 16p13.1-p12 | Mapped by PBA pathway; Mapped by significant region |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| BAD | BCL2-associated agonist of cell death | 11q13.1 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| PPP3R2 | protein phosphatase 3, regulatory subunit B, beta | 9q31 | Mapped by significant region |
| PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 16q24.1 | Mapped by significant region |