ADHDgene Database

Gene Report

Basic Info

Approved Symbol	LIPG
Symbol Alias	EDL
Approved Name	lipase, endothelial
Location	18q21.1
Position	chr18:47088427-47119278, +
External Links	HGNC: 6623 Entrez Gene: 9388 Ensembl: ENSG00000101670 UCSC: uc002ldv.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004091	carboxylesterase activity	Molecular Function		40
GO:0016298	lipase activity	Molecular Function		49

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0055091	phospholipid homeostasis	Biological Process	IMP[19136670]	3
GO:0050253	retinyl-palmitate esterase activity	Molecular Function		9
GO:0050746	regulation of lipoprotein metabolic process	Biological Process		1
GO:0042632	cholesterol homeostasis	Biological Process	IMP[19136670]	18
GO:0043691	reverse cholesterol transport	Biological Process	IMP[19136670]	7
GO:0032376	positive regulation of cholesterol transport	Biological Process	IDA[19136670]	1
GO:0034375	high-density lipoprotein particle remodeling	Biological Process	IMP[19136670]	5
GO:0004620	phospholipase activity	Molecular Function	IDA[10192396]	4
GO:0004465	lipoprotein lipase activity	Molecular Function		3
GO:0005615	extracellular space	Cellular Component	IDA[10192396]	126
GO:0004806	triglyceride lipase activity	Molecular Function		10
GO:0009395	phospholipid catabolic process	Biological Process	NAS[19136670]	4
GO:0008970	phosphatidylcholine 1-acylhydrolase activity	Molecular Function	IDA[10318835]	3
GO:0010983	positive regulation of high-density lipoprotein particle clearance	Biological Process	IMP[19136670]	1
GO:0007584	response to nutrient	Biological Process		15
GO:0006629	lipid metabolic process	Biological Process	TAS[10318835]	51
GO:0008283	cell proliferation	Biological Process		60
GO:0008201	heparin binding	Molecular Function		26

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00561	Glycerolipid metabolism	15

Genes shared at least 5 GO terms with LIPG (count: 8)

Gene Symbol	Pathway Count	Pathway List
PNLIPRP2	8	retinyl-palmitate esterase activity; phospholipase activity; extracellular space; triglyceride lipase activity; carboxylesterase activity; phospholipid catabolic process; lipase activity; lipid metabolic process;
LPL	8	phospholipase activity; lipoprotein lipase activity; extracellular space; triglyceride lipase activity; carboxylesterase activity; lipase activity; lipid metabolic process; heparin binding;
APOA1	7	phospholipid homeostasis; cholesterol homeostasis; reverse cholesterol transport; high-density lipoprotein particle remodeling; extracellular space; response to nutrient; lipid metabolic process;
APOC2	6	cholesterol homeostasis; reverse cholesterol transport; extracellular space; carboxylesterase activity; lipase activity; lipid metabolic process;
APOC3	6	cholesterol homeostasis; reverse cholesterol transport; high-density lipoprotein particle remodeling; extracellular space; response to nutrient; lipid metabolic process;
PNLIP	5	retinyl-palmitate esterase activity; triglyceride lipase activity; carboxylesterase activity; lipase activity; lipid metabolic process;
APOA4	5	cholesterol homeostasis; reverse cholesterol transport; high-density lipoprotein particle remodeling; extracellular space; lipid metabolic process;
PNLIPRP1	5	extracellular space; triglyceride lipase activity; carboxylesterase activity; lipase activity; lipid metabolic process;

Genes shared at least 2 KEGG pathways with LIPG (count: 13)

Gene Symbol	Pathway Count	Pathway List
ALDH3A2	2	Metabolic pathways; Glycerolipid metabolism;
DAK	2	Metabolic pathways; Glycerolipid metabolism;
DGAT2	2	Metabolic pathways; Glycerolipid metabolism;
DGKH	2	Metabolic pathways; Glycerolipid metabolism;
GPAT2	2	Metabolic pathways; Glycerolipid metabolism;
LIPF	2	Metabolic pathways; Glycerolipid metabolism;
MBOAT1	2	Metabolic pathways; Glycerolipid metabolism;
MBOAT2	2	Metabolic pathways; Glycerolipid metabolism;
MGLL	2	Metabolic pathways; Glycerolipid metabolism;
PNLIP	2	Metabolic pathways; Glycerolipid metabolism;
PNLIPRP1	2	Metabolic pathways; Glycerolipid metabolism;
PNLIPRP2	2	Metabolic pathways; Glycerolipid metabolism;
PNPLA3	2	Metabolic pathways; Glycerolipid metabolism;

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Region: chr18:47088427..47119278 View in gBrowse