ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	BAAT
Symbol Alias	BAT
Approved Name	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
Previous Name	bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)
Location	9q22.3
Position	chr9:104122699-104147287, -
External Links	HGNC: 932 Entrez Gene: 570 Ensembl: ENSG00000136881 UCSC: uc010mtd.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q31.1-33.1	chr9:102600000-122500000	1 (1/0/0)

Gene related GO terms (count: 22)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004091	carboxylesterase activity	Molecular Function		40

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001889	liver development	Biological Process		14
GO:0052816	long-chain acyl-CoA hydrolase activity	Molecular Function	IDA[12810727]	1
GO:0052815	medium-chain acyl-CoA hydrolase activity	Molecular Function	IDA[12810727]	1
GO:0047963	glycine N-choloyltransferase activity	Molecular Function	IDA[8034703]	1
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0052817	very long chain acyl-CoA hydrolase activity	Molecular Function	IDA[12810727]	1
GO:0008206	bile acid metabolic process	Biological Process		8
GO:0015721	bile acid and bile salt transport	Biological Process		4
GO:0006637	acyl-CoA metabolic process	Biological Process	IDA[12810727]	2
GO:0006699	bile acid biosynthetic process	Biological Process	IDA[12810727]	4
GO:0019530	taurine metabolic process	Biological Process	IDA[8034703]	2
GO:0031100	organ regeneration	Biological Process		11
GO:0016290	palmitoyl-CoA hydrolase activity	Molecular Function		1
GO:0016410	N-acyltransferase activity	Molecular Function	IDA[12239217]	1
GO:0005102	receptor binding	Molecular Function		61
GO:0005777	peroxisome	Cellular Component	IDA[17256745]	15
GO:0002152	bile acid conjugation	Biological Process	IDA[12810727]	1
GO:0006544	glycine metabolic process	Biological Process	IDA[8034703]	2
GO:0006631	fatty acid metabolic process	Biological Process		15
GO:0005782	peroxisomal matrix	Cellular Component		5
GO:0005829	cytosol	Cellular Component	IDA[17256745]	447

Gene related KEGG pathways (count: 6)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00120	Primary bile acid biosynthesis	4	Bile acids are steroid carboxylic acids derived from cholest...... Bile acids are steroid carboxylic acids derived from cholesterol in vertebrates. The primary bile acids, cholic acid and chenodeoxycholic acid, are synthesized in the liver and conjugated with taurine or glycine before secretion via bile into the intestine. The conversion from cholesterol to cholic and chenodeoxycholic acids involves four steps: 1) the initiation of synthesis by 7alpha-hydroxylation of sterol precursors, 2) further modifications to the ring structures, 3) side-chain oxidation and shortening (cleavage) by three carbons, and 4) conjugation of the bile acid with taurine or glycine. More...
hsa04146	Peroxisome	9	Peroxisomes are essential organelles that play a key role in...... Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies. More...
hsa01100	Metabolic pathways	237
hsa04976	Bile secretion	13	Bile is a vital secretion, essential for digestion and absor...... Bile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol and many waste product, bilirubin, drugs and toxic compounds. Bile secretion depends on the function of membrane transport systems in hepatocytes and cholangiocytes and on the structural and functional integrity of the biliary tree. The hepatocytes generate the so-called primary bile in their canaliculi. Cholangiocytes modify the canalicular bile by secretory and reabsorptive processes as bile passes through the bile ducts. The main solutes in bile are bile acids, which stimulate bile secretion osmotically, as well as facilitate the intestinal absorption of dietary lipids by their detergent properties. Bile acids are also important signalling molecules. Through the activation of nuclear receptors, they regulate their own synthesis and transport rates. More...
hsa01040	Biosynthesis of unsaturated fatty acids	5
hsa00430	Taurine and hypotaurine metabolism	3

Genes shared at least 5 GO terms with BAAT (count: 1)

Gene Symbol	Pathway Count	Pathway List
AMACR	6	small molecule metabolic process; bile acid metabolic process; bile acid biosynthetic process; receptor binding; peroxisome; peroxisomal matrix;

Genes shared at least 2 KEGG pathways with BAAT (count: 8)

Gene Symbol	Pathway Count	Pathway List
AMACR	3	Primary bile acid biosynthesis; Peroxisome; Metabolic pathways;
CYP27A1	2	Primary bile acid biosynthesis; Metabolic pathways;
HSD3B7	2	Primary bile acid biosynthesis; Metabolic pathways;
MLYCD	2	Peroxisome; Metabolic pathways;
PECR	2	Peroxisome; Biosynthesis of unsaturated fatty acids;
GGT1	2	Metabolic pathways; Taurine and hypotaurine metabolism;
GGT5	2	Metabolic pathways; Taurine and hypotaurine metabolism;
UGT2B4	2	Metabolic pathways; Bile secretion;

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Region: chr9:104122699..104147287 View in gBrowse