ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CHRNA5
Approved Name	cholinergic receptor, nicotinic, alpha 5
Previous Name	cholinergic receptor, nicotinic, alpha polypeptide 5
Location	15q24
Position	chr15:78857862-78887611, +
External Links	HGNC: 1959 Entrez Gene: 1138 Ensembl: ENSG00000169684 UCSC: uc002bdy.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 5)

Literature-origin SNPs (count: 0)

LD-proxies (count: 5)

rs_ID	Location	Functional Annotation
rs16969968	Chr15:78882925(Fwd)	downstream_gene_variant; intron_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant
rs2277550	Chr15:78858263(Fwd)	intron_variant
rs951266	Chr15:78878541(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs7180002	Chr15:78873993(Fwd)	intron_variant
rs17486278	Chr15:78867482(Fwd)	intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0015464	acetylcholine receptor activity	Molecular Function	IDA[1542648]	5
GO:0015276	ligand-gated ion channel activity	Molecular Function		4
GO:0035095	behavioral response to nicotine	Biological Process	IMP[18227835]	4
GO:0030054	cell junction	Cellular Component		77
GO:0045211	postsynaptic membrane	Cellular Component		41
GO:0005886	plasma membrane	Cellular Component		772
GO:0004889	acetylcholine-activated cation-selective channel activity	Molecular Function	NAS[1542648]	5
GO:0006810	transport	Biological Process	NAS[1542648]	62
GO:0005892	acetylcholine-gated channel complex	Cellular Component	IC[1542648]	5
GO:0007268	synaptic transmission	Biological Process		96
GO:0007165	signal transduction	Biological Process	NAS[9009220]	171

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with CHRNA5 (count: 12)

Gene Symbol	Pathway Count	Pathway List
CHRNA3	10	acetylcholine receptor activity; ligand-gated ion channel activity; behavioral response to nicotine; cell junction; postsynaptic membrane; plasma membrane; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; synaptic transmission; signal transduction;
CHRNA4	10	acetylcholine receptor activity; ligand-gated ion channel activity; behavioral response to nicotine; cell junction; postsynaptic membrane; plasma membrane; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; synaptic transmission; signal transduction;
CHRNB4	10	acetylcholine receptor activity; ligand-gated ion channel activity; behavioral response to nicotine; cell junction; postsynaptic membrane; plasma membrane; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; synaptic transmission; signal transduction;
CHRNA7	8	acetylcholine receptor activity; cell junction; postsynaptic membrane; plasma membrane; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; synaptic transmission; signal transduction;
GABRA5	6	cell junction; postsynaptic membrane; plasma membrane; transport; synaptic transmission; signal transduction;
GABRB3	6	cell junction; postsynaptic membrane; plasma membrane; transport; synaptic transmission; signal transduction;
GRIA4	5	cell junction; postsynaptic membrane; plasma membrane; transport; synaptic transmission;
GRIK1	5	cell junction; postsynaptic membrane; plasma membrane; transport; synaptic transmission;
GRIK4	5	cell junction; postsynaptic membrane; plasma membrane; transport; synaptic transmission;
GRIN2A	5	cell junction; postsynaptic membrane; plasma membrane; transport; synaptic transmission;
GRIN2B	5	cell junction; postsynaptic membrane; plasma membrane; transport; synaptic transmission;
HTR3A	5	cell junction; postsynaptic membrane; plasma membrane; transport; synaptic transmission;

Genes shared at least 2 KEGG pathways with CHRNA5 (count: 0)

View in gBrowse

Region: chr15:78857862..78887611 View in gBrowse