ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol CHRNA4
Previous Symbol EBN, EBN1
Symbol Alias BFNC
Approved Name cholinergic receptor, nicotinic, alpha 4 (neuronal)
Previous Name "cholinergic receptor, nicotinic, alpha polypeptide 4"
Name Alias "acetylcholine receptor, nicotinic, alpha 4 (neuronal)"
Location 20q13.33
Position chr20:61975420-62009753, -1
External Links HGNC: 1958
Entrez Gene: 1137
Ensembl: ENSG00000101204
UCSC: uc002yes.3
No. of Studies 7 (significant: 4; non-significant: 3; trend: 0)
Source Literature-origin; Mapped by Literature SNP

Gene related studies (count: 7)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Kent L, 2001(b) this study did not support an association between the nicotinic acetylcholine alpha 4 receptor Cfo1 polymorphism and ADHD Non-significant
Gizer IR, 2009 The present review suggests a possible association between childhood ADHD and CHRNA4. Non-significant
Bobb AJ, 2005 no polymorphism was associated with ADHD Non-significant
Todd RD, 2003 haplotype CGA corrected P-value=0.022 in latent-class-defined inattentive ADHD; haplotype of Amplicon 2 ETDT P-value=0.016, X2(2df)=8.30 in latent-class-defined inattentive ADHD, ETDT P-value=0.011, X2(2df)=9.12 in DSM-IV any ADHD, ETDT P-value=0.011, X2(2df)=8.96 in DSM-IV inattentive; haplotype of combined ETDT P-value=0.018, X2(14df)=27.3 in latent-class-defined inattentive ADHD, ETDT P-value=0.035, X2(17df)=29 in DSM-IV any ADHD, ETDT P-value=0.027, X2(12df)=23.1 in DSM-IV inattentive Significant
Lee J, 2008 haplotype GAGC P-value=0.041, X2 =4.161 for all subtypes, P-value=0.004, X2 =8.375 in combined subtype; P-value=0.022 in FBAT analysis for hyperactive/impulsive symptoms; CHRNA4 may be involved in ADHD Significant
Guan L, 2009 haplotype association analysis: Nominal P-value=0.037, Empirical P-value=0.224 for ADHD-I. 2 SNPs in this gene achieved significance for ADHD-I, and haplotype association test also achieved significance for ADHD-I. Significant
Brookes K, 2006 UNPHASED TDT P-value=0.0496, global P-value=0.503, WHAP TDT P_sum P-value=0.593; OR=1.32, one or more SNPs with nominal P-value<0.05 located in this gene Significant

Gene related SNPs (count: 8)

Literature-origin SNPs (count: 7)

LD-proxies (count: 1)

Gene related CNVs (count: 0)

Gene related other variant (count: 4)

Gene related regions (count: 0)

Gene related GO terms (count: 33)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 33)

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CHRNA4 (count: 31)

Genes shared at least 2 KEGG pathways with CHRNA4 (count: 0)

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Region: chr20:61975420..62009753 View in gBrowse
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