ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

SNP Report

Basic Info

Name	rs2273506 dbSNP Ensembl
Location	Chr20:61990939(Fwd)
Variant Alleles	G/A
Ancestral Allele	G
Functional Annotation	NMD_transcript_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; synonymous_variant; upstream_gene_variant.
Consequence to Transcript	NMD_transcript_variant(ENST00000498043) intron_variant(ENST00000463705) nc_transcript_variant(ENST00000467563; ENST00000463705) non_coding_exon_variant(ENST00000467563) synonymous_variant(ENST00000498043; ENST00000370263) upstream_gene_variant(ENST00000370257)
No. of Studies	3 (significant: 0; non-significant: 3; trend: 0)
Source	Literature-origin

SNP related studies (count: 3)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Gizer IR, 2009			Meta-analysis model: Fixed: OR=1.19, 95% CI=0.92-1.54, P-val...... Meta-analysis model: Fixed: OR=1.19, 95% CI=0.92-1.54, P-value=0.089; Q-statistic: P-value=0.504, I²=0 More...	The results suggested a trend towards an association with AD...... The results suggested a trend towards an association with ADHD. There was no significant evidence of heterogeneity in effect sizes across studies. A sensitivity analysis indicated that the trend for an association between ADHD and rs2273506 was largely driven by a single study (Todd et al. 2003), as removal of this study reduced the trend towards association to nonsignificance. More...	Non-significant
Brookes K, 2006	A/G		UNPHASED TDT P-value=0.637; WHAP TDT P-value=0.916 UNPHASED TDT P-value=0.637; WHAP TDT P-value=0.916	no significant association was observed no significant association was observed	Non-significant
Bobb AJ, 2005			allelic TDT P-value=0.72, OR=1.12 in case-control analysis; ...... allelic TDT P-value=0.72, OR=1.12 in case-control analysis; allelic TDT P-value=0.27, RR=1.63 in family-based analysis More...	non-significant association non-significant association	Non-significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Genes from other sources (count: 0)

SNPs in LD with rs2273506 (count: 0) View in gBrowse (chr20:61990939..61990939 )