ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

SNP Report

Basic Info
Name rs2273506 dbSNP Ensembl
Location chr20:61990939(Fwd)
Variant Alleles G/A
Ancestral Allele G
Functional Annotation intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; synonymous_variant; upstream_gene_variant.
Consequence to Transcript intron_variant(ENST00000463705)
nc_transcript_variant(ENST00000463705; ENST00000467563)
NMD_transcript_variant(ENST00000498043)
non_coding_exon_variant(ENST00000467563)
synonymous_variant(ENST00000370263; ENST00000498043)
upstream_gene_variant(ENST00000370257)
No. of Studies 3 (significant: 0; non-significant: 3; trend: 0)
Source Literature-origin

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Gizer IR, 2009 Meta-analysis model: Fixed: OR=1.19, 95% CI=0.92-1.54, P-val...... Meta-analysis model: Fixed: OR=1.19, 95% CI=0.92-1.54, P-value=0.089; Q-statistic: P-value=0.504, I2=0 More... The results suggested a trend towards an association with AD...... The results suggested a trend towards an association with ADHD. There was no significant evidence of heterogeneity in effect sizes across studies. A sensitivity analysis indicated that the trend for an association between ADHD and rs2273506 was largely driven by a single study (Todd et al. 2003), as removal of this study reduced the trend towards association to nonsignificance. More... Non-significant
Brookes K, 2006 A/G UNPHASED TDT P-value=0.637; WHAP TDT P-value=0.916 UNPHASED TDT P-value=0.637; WHAP TDT P-value=0.916 no significant association was observed no significant association was observed Non-significant
Bobb AJ, 2005 allelic TDT P-value=0.72, OR=1.12 in case-control analysis; ...... allelic TDT P-value=0.72, OR=1.12 in case-control analysis; allelic TDT P-value=0.27, RR=1.63 in family-based analysis More... non-significant association non-significant association Non-significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Genes from other sources Help (count: 0)


SNPs in LD with rs2273506 (count: 0) View in gBrowse (chr20:61990939..61990939 )