ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0001666
Name response to hypoxia
Type biological process
No. of Genes in ADHDgene  41
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 41)

Literature-origin genes (count: 10)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
TH tyrosine hydroxylase 11p15.5 7(2/5/0) IDA[17520326]
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 20q13.33 7(4/3/0) IDA[12189247]
VEGFA vascular endothelial growth factor A 6p12 1(0/1/0) IDA[16490744]
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 15q13.3 2(0/1/1) IDA[12189247]
DRD2 dopamine receptor D2 11q22-q23 10(3/7/0) IEA
NR4A2 nuclear receptor subfamily 4, group A, member 2 2q22-q23 2(0/2/0) IEA
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 17q11.2 26(13/13/0) IEA
NOS1 nitric oxide synthase 1 (neuronal) 12q24.22 1(1/0/0) IEP[16276418]
NPPC natriuretic peptide C 2q37.1 1(0/1/0) IEA
BDNF brain-derived neurotrophic factor 11p14.1 16(8/8/0) IEA

Genes from other sources Help (count: 31)

Approved Symbol Approved Name Source Evidence[PMID]
SOD3 superoxide dismutase 3, extracellular Mapped by CNV IEA
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) Mapped by CNV; Mapped by significant region IEA
SCFD1 sec1 family domain containing 1 Mapped by significant region IEA
ADAM17 ADAM metallopeptidase domain 17 Mapped by significant region IDA[18276953]
TSC2 tuberous sclerosis 2 Mapped by significant region IEA
RYR2 ryanodine receptor 2 (cardiac) Mapped by CNV; Mapped by PBA pathway ISS
ALKBH5 alkB, alkylation repair homolog 5 (E. coli) Mapped by significant region IDA
CREBBP CREB binding protein Mapped by significant region TAS[15261140]
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 Mapped by Literature SNP IDA[19120137]
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 Mapped by significant region IEA
NRF1 nuclear respiratory factor 1 Mapped by LD-proxy IEA
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 Mapped by significant region IEA
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) Mapped by CNV; Mapped by significant region IEA
NOX4 NADPH oxidase 4 Mapped by significant region IEA
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 Mapped by CNV ISS
CRYAB crystallin, alpha B Mapped by significant region IEA
HMOX2 heme oxygenase (decycling) 2 Mapped by significant region IDA[15528406]
P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3 Mapped by significant region IEA
CASP1 caspase 1, apoptosis-related cysteine peptidase Mapped by significant region IEA
NARFL nuclear prelamin A recognition factor-like Mapped by significant region IDA[16956324]
EDNRA endothelin receptor type A Mapped by PBA pathway IEA
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 Mapped by significant region IEA
ABAT 4-aminobutyrate aminotransferase Mapped by significant region IEA
PDIA2 protein disulfide isomerase family A, member 2 Mapped by significant region IMP[12095988]
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 Mapped by CNV IDA[19120137]
RYR1 ryanodine receptor 1 (skeletal) Mapped by PBA pathway IDA[19120137]
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit Mapped by significant region NAS[8557660]
IL18 interleukin 18 (interferon-gamma-inducing factor) Mapped by significant region IEA
EGLN3 egl-9 family hypoxia-inducible factor 3 Mapped by Literature SNP IEP
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 Mapped by significant region IEA
ATM ataxia telangiectasia mutated Mapped by CNV; Mapped by significant region IEA