ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NOX4
Symbol Alias	KOX-1, KOX
Approved Name	NADPH oxidase 4
Location	11q14.2-q21
Position	chr11:89057521-89231363, -
External Links	HGNC: 7891 Entrez Gene: 50507 Ensembl: ENSG00000086991 UCSC: uc001pct.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 39)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 39)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035051	cardiocyte differentiation	Biological Process		1
GO:0042554	superoxide anion generation	Biological Process	ISS[10869423]	5
GO:0019826	oxygen sensor activity	Molecular Function	TAS[10869423]	1
GO:0020037	heme binding	Molecular Function	TAS[10869423]	23
GO:0016175	superoxide-generating NADPH oxidase activity	Molecular Function		2
GO:0016324	apical plasma membrane	Cellular Component		51
GO:0016021	integral to membrane	Cellular Component	TAS[10869423]	845
GO:0016174	NAD(P)H oxidase activity	Molecular Function	TAS[10869423]	3
GO:0009055	electron carrier activity	Molecular Function	TAS[10869423]	18
GO:0014911	positive regulation of smooth muscle cell migration	Biological Process		2
GO:0007569	cell aging	Biological Process	ISS[10869423]	4
GO:0008285	negative regulation of cell proliferation	Biological Process	ISS[10869423]	59
GO:0005925	focal adhesion	Cellular Component		26
GO:0006954	inflammatory response	Biological Process	TAS[10869423]	51
GO:0005739	mitochondrion	Cellular Component		183
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0072341	modified amino acid binding	Molecular Function		3
GO:0071560	cellular response to transforming growth factor beta stimulus	Biological Process		9
GO:0071480	cellular response to gamma radiation	Biological Process		4
GO:0071333	cellular response to glucose stimulus	Biological Process		8
GO:0071320	cellular response to cAMP	Biological Process		5
GO:0070374	positive regulation of ERK1 and ERK2 cascade	Biological Process		22
GO:0055114	oxidation-reduction process	Biological Process	IDA[10869423]	15
GO:0051897	positive regulation of protein kinase B signaling cascade	Biological Process		17
GO:0051496	positive regulation of stress fiber assembly	Biological Process		7
GO:0050667	homocysteine metabolic process	Biological Process		3
GO:0050660	flavin adenine dinucleotide binding	Molecular Function	TAS[10869423]	11
GO:0048471	perinuclear region of cytoplasm	Cellular Component		87
GO:0045453	bone resorption	Biological Process		4
GO:0043406	positive regulation of MAP kinase activity	Biological Process		10
GO:0043065	positive regulation of apoptotic process	Biological Process		34
GO:0043020	NADPH oxidase complex	Cellular Component		3
GO:0072593	reactive oxygen species metabolic process	Biological Process	IDA[10869423]	7
GO:2000379	positive regulation of reactive oxygen species metabolic process	Biological Process		2
GO:2000573	positive regulation of DNA biosynthetic process	Biological Process		1
GO:0000902	cell morphogenesis	Biological Process	ISS[10869423]	7
GO:0000166	nucleotide binding	Molecular Function	TAS[10869423]	73
GO:0005634	nucleus	Cellular Component		770
GO:0001666	response to hypoxia	Biological Process		34

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with NOX4 (count: 7)

Gene Symbol	Pathway Count	Pathway List
CYBA	11	superoxide anion generation; heme binding; superoxide-generating NADPH oxidase activity; apical plasma membrane; electron carrier activity; inflammatory response; mitochondrion; cellular response to gamma radiation; cellular response to glucose stimulus; oxidation-reduction process; NADPH oxidase complex;
DUOX1	6	superoxide anion generation; heme binding; apical plasma membrane; integral to membrane; NAD(P)H oxidase activity; oxidation-reduction process;
WWOX	6	mitochondrion; cellular response to transforming growth factor beta stimulus; oxidation-reduction process; positive regulation of apoptotic process; nucleotide binding; nucleus;
CYP2E1	5	heme binding; electron carrier activity; mitochondrion; endoplasmic reticulum membrane; oxidation-reduction process;
DUOX2	5	heme binding; apical plasma membrane; integral to membrane; NAD(P)H oxidase activity; oxidation-reduction process;
ERBB2	5	apical plasma membrane; integral to membrane; perinuclear region of cytoplasm; positive regulation of MAP kinase activity; nucleus;
PYCARD	5	inflammatory response; mitochondrion; positive regulation of ERK1 and ERK2 cascade; positive regulation of apoptotic process; nucleus;

Genes shared at least 2 KEGG pathways with NOX4 (count: 0)

View in gBrowse

Region: chr11:89057521..89231363 View in gBrowse