ADHDgene Database

Gene Report

Basic Info

Approved Symbol	DUOX2
Symbol Alias	P138-TOX, P138(TOX), THOX2, LNOX2
Approved Name	dual oxidase 2
Name Alias	dual oxidase-like domains 2, "nicotinamide adenine dinucleotide phosphate oxidase", "flavoprotein NADPH oxidase", "NADPH thyroid oxidase 2", "NADH/NADPH thyroid oxidase p138-tox", "NADPH oxidase/peroxidase DUOX2"
Location	15q15.3-q21
Position	chr15:45384848-45406537, -
External Links	HGNC: 13273 Entrez Gene: 50506 Ensembl: ENSG00000140279 UCSC: uc010bea.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_170	chr15:43087208-43281530 (NCBI Build 35 (hg17))	194323	15q21.1	Deletion (hemizygous)	Paternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006590	thyroid hormone generation	Biological Process		5
GO:0009566	fertilization	Biological Process		3
GO:0009615	response to virus	Biological Process	IDA[16111680]	21
GO:0016021	integral to membrane	Cellular Component		845
GO:0016174	NAD(P)H oxidase activity	Molecular Function	IDA[15972824]	3
GO:0016324	apical plasma membrane	Cellular Component		51
GO:0019221	cytokine-mediated signaling pathway	Biological Process	IDA[16111680]	28
GO:0020037	heme binding	Molecular Function		23
GO:0004601	peroxidase activity	Molecular Function		4
GO:0005509	calcium ion binding	Molecular Function	IDA[15972824]	124
GO:0055114	oxidation-reduction process	Biological Process	TAS[10601291]	15
GO:0051591	response to cAMP	Biological Process	IDA[15062544]	11
GO:0042335	cuticle development	Biological Process		2
GO:0035264	multicellular organism growth	Biological Process		10
GO:0030878	thyroid gland development	Biological Process		7
GO:0030282	bone mineralization	Biological Process		5
GO:0048855	adenohypophysis morphogenesis	Biological Process		1
GO:0048839	inner ear development	Biological Process		5
GO:0042744	hydrogen peroxide catabolic process	Biological Process		5
GO:0042446	hormone biosynthetic process	Biological Process		3

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with DUOX2 (count: 2)

Gene Symbol	Pathway Count	Pathway List
DUOX1	13	thyroid hormone generation; integral to membrane; NAD(P)H oxidase activity; apical plasma membrane; cytokine-mediated signaling pathway; heme binding; peroxidase activity; calcium ion binding; oxidation-reduction process; response to cAMP; cuticle development; hydrogen peroxide catabolic process; hormone biosynthetic process;
NOX4	5	integral to membrane; NAD(P)H oxidase activity; apical plasma membrane; heme binding; oxidation-reduction process;

Genes shared at least 2 KEGG pathways with DUOX2 (count: 0)

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Region: chr15:45384848..45406537 View in gBrowse