ADHDgene Database

Gene Report

Basic Info

Approved Symbol	DUOX1
Symbol Alias	NOXEF1, THOX1, LNOX1
Approved Name	dual oxidase 1
Name Alias	NADPH thyroid oxidase 1, "flavoprotein NADPH oxidase", "nicotinamide adenine dinucleotide phosphate oxidase"
Location	15q21
Position	chr15:45422192-45457774, +
External Links	HGNC: 3062 Entrez Gene: 53905 Ensembl: ENSG00000137857 UCSC: uc001zut.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_170	chr15:43087208-43281530 (NCBI Build 35 (hg17))	194323	15q21.1	Deletion (hemizygous)	Paternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0042554	superoxide anion generation	Biological Process	NAS[10806195]	5
GO:0042744	hydrogen peroxide catabolic process	Biological Process		5
GO:0050661	NADP binding	Molecular Function	NAS[10806195]	6
GO:0050665	hydrogen peroxide biosynthetic process	Biological Process	NAS[10806195]	2
GO:0051591	response to cAMP	Biological Process	IDA[15062544]	11
GO:0055114	oxidation-reduction process	Biological Process	TAS[10601291]	15
GO:0016021	integral to membrane	Cellular Component		845
GO:0006590	thyroid hormone generation	Biological Process		5
GO:0016324	apical plasma membrane	Cellular Component	NAS[10806195]	51
GO:0016174	NAD(P)H oxidase activity	Molecular Function	NAS[10806195]	3
GO:0020037	heme binding	Molecular Function		23
GO:0019221	cytokine-mediated signaling pathway	Biological Process	IDA[16111680]	28
GO:0042446	hormone biosynthetic process	Biological Process		3
GO:0042335	cuticle development	Biological Process	IMP[11514595]	2
GO:0005509	calcium ion binding	Molecular Function		124
GO:0004601	peroxidase activity	Molecular Function		4

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with DUOX1 (count: 3)

Gene Symbol	Pathway Count	Pathway List
DUOX2	13	hydrogen peroxide catabolic process; response to cAMP; oxidation-reduction process; integral to membrane; thyroid hormone generation; apical plasma membrane; NAD(P)H oxidase activity; heme binding; cytokine-mediated signaling pathway; hormone biosynthetic process; cuticle development; calcium ion binding; peroxidase activity;
NOX4	6	superoxide anion generation; oxidation-reduction process; integral to membrane; apical plasma membrane; NAD(P)H oxidase activity; heme binding;
CYBA	5	superoxide anion generation; hydrogen peroxide biosynthetic process; oxidation-reduction process; apical plasma membrane; heme binding;

Genes shared at least 2 KEGG pathways with DUOX1 (count: 0)

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Region: chr15:45422192..45457774 View in gBrowse