ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GRID2
Symbol Alias	GluR-delta-2
Approved Name	glutamate receptor, ionotropic, delta 2
Location	4q22
Position	chr4:93225550-94695707, +
External Links	HGNC: 4576 Entrez Gene: 2895 Ensembl: ENSG00000152208 UCSC: uc011cdt.1
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Stergiakouli E., 2012	One of the top 20 independent SNPs with P=0.0000209 locates intronic relative to this gene.	Trend

Gene related SNPs (count: 18)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs6815704	Chr4:93474566(Fwd)	intron_variant; nc_transcript_variant	1(0/0/1)

LD-proxies (count: 17)

rs_ID	Location	Functional Annotation
rs7700132	Chr4:93467282(Fwd)	intron_variant; nc_transcript_variant
rs7667109	Chr4:93463316(Fwd)	intron_variant; nc_transcript_variant
rs17019530	Chr4:93466887(Fwd)	intron_variant; nc_transcript_variant
rs1376116	Chr4:93472319(Fwd)	intron_variant; nc_transcript_variant
rs7677052	Chr4:93475423(Fwd)	intron_variant; nc_transcript_variant
rs12508375	Chr4:93478587(Fwd)	intron_variant; nc_transcript_variant
rs7699810	Chr4:93496946(Fwd)	intron_variant; nc_transcript_variant
rs11730247	Chr4:93501374(Fwd)	intron_variant; nc_transcript_variant
rs11934085	Chr4:93515166(Fwd)	intron_variant; nc_transcript_variant
rs17019538	Chr4:93467552(Fwd)	intron_variant; nc_transcript_variant
rs6532375	Chr4:93475443(Fwd)	intron_variant; nc_transcript_variant
rs17019568	Chr4:93479889(Fwd)	intron_variant; nc_transcript_variant
rs7663643	Chr4:93480717(Fwd)	intron_variant; nc_transcript_variant
rs1971197	Chr4:93452467(Fwd)	intron_variant; nc_transcript_variant
rs6848991	Chr4:93455252(Fwd)	intron_variant; nc_transcript_variant
rs7686758	Chr4:93463035(Fwd)	intron_variant; nc_transcript_variant
rs1376115	Chr4:93466614(Fwd)	intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007215	glutamate receptor signaling pathway	Biological Process	TAS[9465309]	6
GO:0006810	transport	Biological Process	TAS[9465309]	62
GO:0005887	integral to plasma membrane	Cellular Component	TAS[9465309]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0030165	PDZ domain binding	Molecular Function		13
GO:0030054	cell junction	Cellular Component		77
GO:0008328	ionotropic glutamate receptor complex	Cellular Component		2
GO:0008066	glutamate receptor activity	Molecular Function	TAS[9465309]	6
GO:0043197	dendritic spine	Cellular Component		12
GO:0035249	synaptic transmission, glutamatergic	Biological Process		7
GO:0034613	cellular protein localization	Biological Process		9
GO:0030288	outer membrane-bounded periplasmic space	Cellular Component		4
GO:0060079	regulation of excitatory postsynaptic membrane potential	Biological Process		9
GO:0045211	postsynaptic membrane	Cellular Component		41
GO:0045202	synapse	Cellular Component		31
GO:0043523	regulation of neuron apoptotic process	Biological Process		3
GO:0060134	prepulse inhibition	Biological Process		10
GO:0097110	scaffold protein binding	Molecular Function		6
GO:0004970	ionotropic glutamate receptor activity	Molecular Function		2
GO:0005234	extracellular-glutamate-gated ion channel activity	Molecular Function		8

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04730	Long-term depression	27	Cerebellar long-term depression (LTD), thought to be a molec...... Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple signal transduction pathways have been shown to be involved in this process. Activation of PFs terminating on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple synaptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular signals, generated from two different synaptic origins, trigger a cascade of events culminating in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC synapse. This may take place either through receptor internalization and/or through receptor desensitization. More...
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with GRID2 (count: 12)

Gene Symbol	Pathway Count	Pathway List
GRIK1	9	glutamate receptor signaling pathway; transport; integral to plasma membrane; plasma membrane; cell junction; synaptic transmission, glutamatergic; regulation of excitatory postsynaptic membrane potential; postsynaptic membrane; extracellular-glutamate-gated ion channel activity;
GRIN2A	9	glutamate receptor signaling pathway; transport; integral to plasma membrane; plasma membrane; cell junction; outer membrane-bounded periplasmic space; regulation of excitatory postsynaptic membrane potential; postsynaptic membrane; extracellular-glutamate-gated ion channel activity;
GRIN2B	9	glutamate receptor signaling pathway; transport; integral to plasma membrane; plasma membrane; cell junction; outer membrane-bounded periplasmic space; regulation of excitatory postsynaptic membrane potential; postsynaptic membrane; extracellular-glutamate-gated ion channel activity;
GRIA4	7	glutamate receptor signaling pathway; transport; plasma membrane; cell junction; postsynaptic membrane; ionotropic glutamate receptor activity; extracellular-glutamate-gated ion channel activity;
GRIK4	7	glutamate receptor signaling pathway; transport; integral to plasma membrane; plasma membrane; cell junction; postsynaptic membrane; extracellular-glutamate-gated ion channel activity;
ADORA2A	6	integral to plasma membrane; plasma membrane; synaptic transmission, glutamatergic; regulation of excitatory postsynaptic membrane potential; postsynaptic membrane; prepulse inhibition;
GRIN3A	6	cell junction; outer membrane-bounded periplasmic space; postsynaptic membrane; synapse; prepulse inhibition; extracellular-glutamate-gated ion channel activity;
GABRA5	5	transport; integral to plasma membrane; plasma membrane; cell junction; postsynaptic membrane;
GABRB3	5	transport; integral to plasma membrane; plasma membrane; cell junction; postsynaptic membrane;
HTR3A	5	transport; integral to plasma membrane; plasma membrane; cell junction; postsynaptic membrane;
GRM7	5	integral to plasma membrane; plasma membrane; PDZ domain binding; glutamate receptor activity; postsynaptic membrane;
SHANK2	5	plasma membrane; cell junction; ionotropic glutamate receptor complex; dendritic spine; postsynaptic membrane;

Genes shared at least 2 KEGG pathways with GRID2 (count: 2)

Gene Symbol	Pathway Count	Pathway List
GRM1	2	Long-term depression; Neuroactive ligand-receptor interaction;
GRM5	2	Long-term depression; Neuroactive ligand-receptor interaction;

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Region: chr4:93225550..94695707 View in gBrowse