ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GRID2
Symbol Alias	GluD2, GluR-delta-2
Approved Name	glutamate receptor, ionotropic, delta 2
Location	4q22
Position	chr4:93225550-94695707, 1
External Links	HGNC: 4576 Entrez Gene: 2895 Ensembl: ENSG00000152208 UCSC: uc011cdt.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Stergiakouli E., 2012	One of the top 20 independent SNPs with P=0.0000209 locates intronic relative to this gene.	Trend

Gene related SNPs (count: 18)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs6815704	chr4:93474566(Fwd)	intron_variant; nc_transcript_variant	1(0/0/1)

LD-proxies (count: 17)

rs_ID	Location	Functional Annotation
rs11730247	chr4:93501374(Fwd)	intron_variant; nc_transcript_variant
rs7699810	chr4:93496946(Fwd)	intron_variant; nc_transcript_variant
rs11934085	chr4:93515166(Fwd)	intron_variant; nc_transcript_variant
rs7700132	chr4:93467282(Fwd)	intron_variant; nc_transcript_variant
rs17019538	chr4:93467552(Fwd)	intron_variant; nc_transcript_variant
rs1376116	chr4:93472319(Fwd)	intron_variant; nc_transcript_variant
rs7677052	chr4:93475423(Fwd)	intron_variant; nc_transcript_variant
rs6532375	chr4:93475443(Fwd)	intron_variant; nc_transcript_variant
rs12508375	chr4:93478587(Fwd)	intron_variant; nc_transcript_variant
rs17019568	chr4:93479889(Fwd)	intron_variant; nc_transcript_variant
rs7663643	chr4:93480717(Fwd)	intron_variant; nc_transcript_variant
rs1971197	chr4:93452467(Fwd)	intron_variant; nc_transcript_variant
rs6848991	chr4:93455252(Fwd)	intron_variant; nc_transcript_variant
rs7686758	chr4:93463035(Fwd)	intron_variant; nc_transcript_variant
rs7667109	chr4:93463316(Fwd)	intron_variant; nc_transcript_variant
rs1376115	chr4:93466614(Fwd)	intron_variant; nc_transcript_variant
rs17019530	chr4:93466887(Fwd)	intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0097110	scaffold protein binding	molecular function	ISS	6
GO:0043197	dendritic spine	cellular component	ISS	12
GO:0004970	ionotropic glutamate receptor activity	molecular function	IEA	2
GO:0060134	prepulse inhibition	biological process	ISS	10
GO:0005234	extracellular-glutamate-gated ion channel activity	molecular function	IEA	8
GO:0008328	ionotropic glutamate receptor complex	cellular component	ISS	3
GO:0006810	transport	biological process	TAS[9465309]	67
GO:0005886	plasma membrane	cellular component	ISS	839
GO:0005887	integral to plasma membrane	cellular component	TAS[9465309]	236
GO:0008066	glutamate receptor activity	molecular function	TAS[9465309]	6
GO:0030165	PDZ domain binding	molecular function	ISS	13
GO:0034613	cellular protein localization	biological process	ISS	9
GO:0007215	glutamate receptor signaling pathway	biological process	TAS[9465309]	6
GO:0035249	synaptic transmission, glutamatergic	biological process	ISS	7
GO:0060079	regulation of excitatory postsynaptic membrane potential	biological process	ISS	9
GO:0045202	synapse	cellular component	ISS	35
GO:0030288	outer membrane-bounded periplasmic space	cellular component	IEA	4
GO:0043523	regulation of neuron apoptotic process	biological process	ISS	4
GO:0045211	postsynaptic membrane	cellular component	IEA	45
GO:0030054	cell junction	cellular component	IEA	84

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04730	Long-term depression	27
hsa04080	Neuroactive ligand-receptor interaction	89

Genes shared at least 5 GO terms with GRID2 (count: 12)

Gene Symbol	Pathway Count	Pathway List
GRIN2A	9	extracellular-glutamate-gated ion channel activity; transport; plasma membrane; integral to plasma membrane; glutamate receptor signaling pathway; regulation of excitatory postsynaptic membrane potential; outer membrane-bounded periplasmic space; postsynaptic membrane; cell junction;
GRIN2B	9	extracellular-glutamate-gated ion channel activity; transport; plasma membrane; integral to plasma membrane; glutamate receptor signaling pathway; regulation of excitatory postsynaptic membrane potential; outer membrane-bounded periplasmic space; postsynaptic membrane; cell junction;
GRIK1	9	extracellular-glutamate-gated ion channel activity; transport; plasma membrane; integral to plasma membrane; glutamate receptor signaling pathway; synaptic transmission, glutamatergic; regulation of excitatory postsynaptic membrane potential; postsynaptic membrane; cell junction;
GRIA4	7	ionotropic glutamate receptor activity; extracellular-glutamate-gated ion channel activity; transport; plasma membrane; glutamate receptor signaling pathway; postsynaptic membrane; cell junction;
GRIK4	7	extracellular-glutamate-gated ion channel activity; transport; plasma membrane; integral to plasma membrane; glutamate receptor signaling pathway; postsynaptic membrane; cell junction;
ADORA2A	6	prepulse inhibition; plasma membrane; integral to plasma membrane; synaptic transmission, glutamatergic; regulation of excitatory postsynaptic membrane potential; postsynaptic membrane;
GRIN3A	6	prepulse inhibition; extracellular-glutamate-gated ion channel activity; synapse; outer membrane-bounded periplasmic space; postsynaptic membrane; cell junction;
SHANK2	5	dendritic spine; ionotropic glutamate receptor complex; plasma membrane; postsynaptic membrane; cell junction;
GABRA5	5	transport; plasma membrane; integral to plasma membrane; postsynaptic membrane; cell junction;
HTR3A	5	transport; plasma membrane; integral to plasma membrane; postsynaptic membrane; cell junction;
GABRB3	5	transport; plasma membrane; integral to plasma membrane; postsynaptic membrane; cell junction;
GRM7	5	plasma membrane; integral to plasma membrane; glutamate receptor activity; PDZ domain binding; postsynaptic membrane;

Genes shared at least 2 KEGG pathways with GRID2 (count: 2)

Gene Symbol	Pathway Count	Pathway List
GRM1	2	Long-term depression; Neuroactive ligand-receptor interaction;
GRM5	2	Long-term depression; Neuroactive ligand-receptor interaction;

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Region: chr4:93225550..94695707 View in gBrowse