ADHDgene Database

Gene Report

Basic Info

Approved Symbol	GPX6
Previous Symbol	GPXP3
Approved Name	glutathione peroxidase 6 (olfactory)
Previous Name	glutathione peroxidase pseudogene 3
Location	6p22.1
Position	chr6:28471073-28503695, -
External Links	HGNC: 4558 Entrez Gene: 257202 Ensembl: ENSG00000198704 UCSC: uc011dlj.1
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hinney, A., 2011	This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08.	Non-significant

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs11757000	Chr6:28484869(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs722788	Chr6:28483150(Fwd)	intron_variant; nc_transcript_variant
rs11757235	Chr6:28489279(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 3)

ID	Name	Type	No. of Genes in ADHDgene
GO:0005576	extracellular region	Cellular Component	240
GO:0004602	glutathione peroxidase activity	Molecular Function	5
GO:0006979	response to oxidative stress	Biological Process	17

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00590	Arachidonic acid metabolism	16
hsa00480	Glutathione metabolism	9

Genes shared at least 5 GO terms with GPX6 (count: 0)

Genes shared at least 2 KEGG pathways with GPX6 (count: 3)

Gene Symbol	Pathway Count	Pathway List
GGT1	2	Arachidonic acid metabolism; Glutathione metabolism;
GGT5	2	Arachidonic acid metabolism; Glutathione metabolism;
GPX5	2	Arachidonic acid metabolism; Glutathione metabolism;

View in gBrowse

Region: chr6:28471073..28503695 View in gBrowse