ADHDgene Database

Gene Report

Basic Info

Approved Symbol	GPX6
Previous Symbol	GPXP3
Approved Name	glutathione peroxidase 6 (olfactory)
Previous Name	"glutathione peroxidase pseudogene 3"
Location	6p22.1
Position	chr6:28471073-28495992, -1
External Links	HGNC: 4558 Entrez Gene: 257202 Ensembl: ENSG00000198704 UCSC: uc021yrx.1
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hinney, A., 2011	This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08.	Non-significant

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs11757000	chr6:28484869(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs722788	chr6:28483150(Fwd)	intron_variant; nc_transcript_variant
rs11757235	chr6:28489279(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005576	extracellular region	cellular component	IEA	267
GO:0004602	glutathione peroxidase activity	molecular function	IEA	5
GO:0006979	response to oxidative stress	biological process	IEA	17

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00480	Glutathione metabolism	8
hsa00590	Arachidonic acid metabolism	15

Genes shared at least 5 GO terms with GPX6 (count: 0)

Genes shared at least 2 KEGG pathways with GPX6 (count: 2)

Gene Symbol	Pathway Count	Pathway List
GPX5	2	Glutathione metabolism; Arachidonic acid metabolism;
GGT1	2	Glutathione metabolism; Arachidonic acid metabolism;

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Region: chr6:28471073..28495992 View in gBrowse