ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GFI1B
Approved Name	growth factor independent 1B transcription repressor
Previous Name	growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)
Location	9q34.13
Position	chr9:135820932-135867084, +
External Links	HGNC: 4238 Entrez Gene: 8328 Ensembl: ENSG00000165702 UCSC: uc004ccg.2
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hinney, A., 2011	This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08.	Non-significant

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2773822	Chr9:135861033(Fwd)	intron_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 1)

rs_ID	Location	Functional Annotation
rs649651	Chr9:135861241(Fwd)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008283	cell proliferation	Biological Process	TAS[9566867]	60
GO:0016363	nuclear matrix	Cellular Component	IDA[12874834]	16
GO:0016568	chromatin modification	Biological Process		16
GO:0005667	transcription factor complex	Cellular Component	IDA[15920471]	51
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	TAS[9566867]	62
GO:0007275	multicellular organismal development	Biological Process		71
GO:0008270	zinc ion binding	Molecular Function		323
GO:0001085	RNA polymerase II transcription factor binding	Molecular Function	IPI[15920471]	10
GO:0003677	DNA binding	Molecular Function		220
GO:0000114	regulation of transcription involved in G1 phase of mitotic cell cycle	Biological Process	TAS[9566867]	1
GO:0005515	protein binding	Molecular Function	IPI[16713569]	910
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	TAS[9566867]	78
GO:0005634	nucleus	Cellular Component	IDA[12874834]	770

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with GFI1B (count: 16)

Gene Symbol	Pathway Count	Pathway List
KDM1A	6	cell proliferation; transcription factor complex; RNA polymerase II transcription factor binding; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleus;
NCOR1	6	chromatin modification; transcription factor complex; transcription from RNA polymerase II promoter; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleus;
DEAF1	6	transcription factor complex; transcription from RNA polymerase II promoter; zinc ion binding; DNA binding; protein binding; nucleus;
GATA6	6	transcription factor complex; transcription from RNA polymerase II promoter; zinc ion binding; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleus;
MTA2	6	transcription factor complex; zinc ion binding; RNA polymerase II transcription factor binding; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleus;
NR6A1	5	cell proliferation; transcription factor complex; zinc ion binding; DNA binding; negative regulation of transcription from RNA polymerase II promoter;
IKZF1	5	chromatin modification; zinc ion binding; DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus;
ETS1	5	transcription factor complex; transcription from RNA polymerase II promoter; DNA binding; protein binding; nucleus;
HNF1B	5	transcription factor complex; DNA binding; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleus;
KLF4	5	transcription factor complex; transcription from RNA polymerase II promoter; zinc ion binding; RNA polymerase II transcription factor binding; negative regulation of transcription from RNA polymerase II promoter;
ZFPM1	5	transcription factor complex; zinc ion binding; RNA polymerase II transcription factor binding; DNA binding; protein binding;
IRF7	5	transcription from RNA polymerase II promoter; DNA binding; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleus;
KLF13	5	transcription from RNA polymerase II promoter; zinc ion binding; DNA binding; protein binding; nucleus;
RREB1	5	transcription from RNA polymerase II promoter; multicellular organismal development; zinc ion binding; DNA binding; nucleus;
ZNF202	5	transcription from RNA polymerase II promoter; zinc ion binding; DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus;
ZFR	5	multicellular organismal development; zinc ion binding; DNA binding; protein binding; nucleus;

Genes shared at least 2 KEGG pathways with GFI1B (count: 0)

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Region: chr9:135820932..135867084 View in gBrowse