ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NR6A1
Previous Symbol	GCNF
Symbol Alias	GCNF1, RTR
Approved Name	nuclear receptor subfamily 6, group A, member 1
Location	9q33.3
Position	chr9:127279888-127533589, -
External Links	HGNC: 7985 Entrez Gene: 2649 Ensembl: ENSG00000148200 UCSC: uc004bor.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q33	chr9:117700000-130300000	2 (1/1/0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0042803	protein homodimerization activity	Molecular Function		113
GO:0030522	intracellular receptor mediated signaling pathway	Biological Process	TAS[9134503]	6
GO:0007276	gamete generation	Biological Process		2
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process		42
GO:0005667	transcription factor complex	Cellular Component		51
GO:0005654	nucleoplasm	Cellular Component		183
GO:0010467	gene expression	Biological Process		140
GO:0008283	cell proliferation	Biological Process	TAS[9134503]	60
GO:0008270	zinc ion binding	Molecular Function		323
GO:0007283	spermatogenesis	Biological Process	TAS[9134503]	35
GO:0003707	steroid hormone receptor activity	Molecular Function		9
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	Molecular Function	TAS[9134503]	6
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0003677	DNA binding	Molecular Function		220

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with NR6A1 (count: 16)

Gene Symbol	Pathway Count	Pathway List
ESRRA	9	sequence-specific DNA binding; intracellular receptor mediated signaling pathway; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; zinc ion binding; steroid hormone receptor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; DNA binding;
NR5A1	9	sequence-specific DNA binding; intracellular receptor mediated signaling pathway; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; zinc ion binding; steroid hormone receptor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; DNA binding;
NR4A2	8	sequence-specific DNA binding; intracellular receptor mediated signaling pathway; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; zinc ion binding; steroid hormone receptor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity;
NR4A3	8	sequence-specific DNA binding; transcription initiation from RNA polymerase II promoter; transcription factor complex; nucleoplasm; gene expression; zinc ion binding; steroid hormone receptor activity; DNA binding;
PGR	8	sequence-specific DNA binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; zinc ion binding; steroid hormone receptor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; DNA binding;
RORA	8	sequence-specific DNA binding; intracellular receptor mediated signaling pathway; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; zinc ion binding; steroid hormone receptor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity;
NCOR1	6	sequence-specific DNA binding; transcription initiation from RNA polymerase II promoter; transcription factor complex; nucleoplasm; gene expression; negative regulation of transcription from RNA polymerase II promoter;
NR3C2	6	sequence-specific DNA binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; zinc ion binding; steroid hormone receptor activity;
FOXP2	5	sequence-specific DNA binding; protein homodimerization activity; transcription factor complex; zinc ion binding; DNA binding;
HNF1B	5	sequence-specific DNA binding; protein homodimerization activity; transcription factor complex; negative regulation of transcription from RNA polymerase II promoter; DNA binding;
MEN1	5	sequence-specific DNA binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; negative regulation of transcription from RNA polymerase II promoter;
E2F5	5	transcription initiation from RNA polymerase II promoter; transcription factor complex; nucleoplasm; gene expression; DNA binding;
NCOR2	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; negative regulation of transcription from RNA polymerase II promoter; DNA binding;
RBPJ	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; negative regulation of transcription from RNA polymerase II promoter; DNA binding;
YAP1	5	transcription initiation from RNA polymerase II promoter; transcription factor complex; nucleoplasm; gene expression; cell proliferation;
GFI1B	5	transcription factor complex; cell proliferation; zinc ion binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding;

Genes shared at least 2 KEGG pathways with NR6A1 (count: 0)

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Region: chr9:127279888..127533589 View in gBrowse