ADHDgene Database

SNP Report

Basic Info

Name	rs2556378 dbSNP Ensembl
Location	chr2:60762502(Fwd)
Variant Alleles	T/G
Ancestral Allele	G
Functional Annotation	intron_variant; nc_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000335712; ENST00000356842; ENST00000358510; ENST00000359629; ENST00000477659; ENST00000489516; ENST00000537768; ENST00000538214) nc_transcript_variant(ENST00000477659; ENST00000489516)
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Hinney, A., 2011		T	GWAS P-value=8.08E-07, OR=1.61, Replication FBAT P-value=0.4...... GWAS P-value=8.08E-07, OR=1.61, Replication FBAT P-value=0.4751, Combination P-value=1.70E-06 More...	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	2p16.1	1(0/0/1)

SNPs in LD with rs2556378 (count: 6) View in gBrowse (chr2:60760032..60774773 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs971563	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[TSI]; 0.86[ASW]; 0.892[CHB]; 0.968[CHD]; 0.843[JPT]; 1.0[GIH]; 0.808[LWK]; 0.947[MEX]; 0.853[MKK]; 0.958[YRI]
rs2556376	intron_variant; nc_transcript_variant; upstream_gene_variant	0.868[CEU]; 0.929[TSI]; 0.947[CHB]; 0.939[CHD]; 0.924[JPT]; 1.0[GIH]; 0.91[LWK]; 1.0[MEX]; 0.931[MKK]; 0.846[YRI]
rs2665668	downstream_gene_variant; intron_variant; nc_transcript_variant	0.947[CHB]; 0.939[CHD]
rs3771270	downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 0.947[CHB]; 0.843[JPT]; 0.958[YRI]
rs2556377	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.965[TSI]; 0.947[CHB]; 0.939[CHD]; 0.924[JPT]; 0.959[GIH]; 0.91[LWK]; 1.0[MEX]; 0.931[MKK]; 0.881[YRI]
rs6739994	downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 0.892[CHB]; 0.924[JPT]; 0.958[YRI]