ADHDgene Database

Gene Report

Basic Info

Approved Symbol	H2AFY
Symbol Alias	macroH2A1.2
Approved Name	H2A histone family, member Y
Location	5q31.1
Position	chr5:134669590-134735604, -1
External Links	HGNC: 4740 Entrez Gene: 9555 Ensembl: ENSG00000113648 UCSC: uc003lam.1
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hinney, A., 2011	This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08.	Non-significant

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2114961	chr5:134574232(Fwd)	intron_variant; nc_transcript_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003682	chromatin binding	molecular function	IEA	50
GO:0046982	protein heterodimerization activity	molecular function	IEA	73
GO:0005515	protein binding	molecular function	IPI	1015
GO:0003677	DNA binding	molecular function	NAS[9714746]	257
GO:0000786	nucleosome	cellular component	NAS[9714746]	7
GO:0007549	dosage compensation	biological process	IDA[15053874]	1
GO:0001740	Barr body	cellular component	IDA[11331621]	1
GO:0000793	condensed chromosome	cellular component	IEA	4
GO:0016568	chromatin modification	biological process	IEA	19
GO:0006334	nucleosome assembly	biological process	NAS[9714746]	10

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05322	Systemic lupus erythematosus	20

Genes shared at least 5 GO terms with H2AFY (count: 1)

Gene Symbol	Pathway Count	Pathway List
H2AFX	5	protein heterodimerization activity; protein binding; DNA binding; nucleosome; nucleosome assembly;

Genes shared at least 2 KEGG pathways with H2AFY (count: 0)

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Region: chr5:134669590..134735604 View in gBrowse