ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RQCD1
Symbol Alias	RCD1, RCD1+, CNOT9, CT129
Approved Name	RCD1 required for cell differentiation1 homolog (S. pombe)
Previous Name	rcd1 (required for cell differentiation, S.pombe) homolog 1
Name Alias	cancer/testis antigen 129
Location	2q35
Position	chr2:219433303-219461803, +
External Links	HGNC: 10445 Entrez Gene: 9125 Ensembl: ENSG00000144580 UCSC: uc010zkh.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006355	regulation of transcription, DNA-dependent	Biological Process		158
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0010467	gene expression	Biological Process		140
GO:0007548	sex differentiation	Biological Process	TAS[9447985]	3
GO:0016071	mRNA metabolic process	Biological Process		34
GO:0016070	RNA metabolic process	Biological Process		46
GO:2000327	positive regulation of ligand-dependent nuclear receptor transcription coactivator activity	Biological Process	IDA[18180299]	2
GO:0019221	cytokine-mediated signaling pathway	Biological Process		28
GO:0005829	cytosol	Cellular Component		447
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[18180299]	910
GO:0000932	cytoplasmic mRNA processing body	Cellular Component		7
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	Biological Process		3
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	Biological Process		7

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03018	RNA degradation	8	The correct processing, quality control and turnover of cell...... The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex. More...

Genes shared at least 5 GO terms with RQCD1 (count: 35)

Gene Symbol	Pathway Count	Pathway List
CNOT6	11	regulation of transcription, DNA-dependent; transcription, DNA-dependent; gene expression; mRNA metabolic process; RNA metabolic process; positive regulation of ligand-dependent nuclear receptor transcription coactivator activity; cytosol; nucleus; protein binding; nuclear-transcribed mRNA poly(A) tail shortening; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
HSPA8	7	transcription, DNA-dependent; gene expression; mRNA metabolic process; RNA metabolic process; cytosol; nucleus; protein binding;
UBB	7	transcription, DNA-dependent; gene expression; mRNA metabolic process; RNA metabolic process; cytokine-mediated signaling pathway; cytosol; protein binding;
UBC	7	transcription, DNA-dependent; gene expression; mRNA metabolic process; RNA metabolic process; cytokine-mediated signaling pathway; cytosol; protein binding;
DCPS	7	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; nucleus; protein binding; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
DDX6	7	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; protein binding; cytoplasmic mRNA processing body; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
PATL1	7	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; protein binding; cytoplasmic mRNA processing body; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
PSMC3	7	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; nucleus; protein binding; cytoplasmic mRNA processing body;
TNKS1BP1	7	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; nucleus; nuclear-transcribed mRNA poly(A) tail shortening; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
EEF1D	6	regulation of transcription, DNA-dependent; transcription, DNA-dependent; gene expression; cytosol; nucleus; protein binding;
LSM4	6	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; protein binding; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
NCBP1	6	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; nucleus; protein binding;
RPS3	6	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; nucleus; protein binding;
SMG1	6	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; nucleus; protein binding;
SMG7	6	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; nucleus; protein binding;
BIRC2	5	regulation of transcription, DNA-dependent; transcription, DNA-dependent; cytosol; nucleus; protein binding;
CTNND1	5	regulation of transcription, DNA-dependent; transcription, DNA-dependent; cytosol; nucleus; protein binding;
DAXX	5	regulation of transcription, DNA-dependent; transcription, DNA-dependent; cytosol; nucleus; protein binding;
HABP4	5	regulation of transcription, DNA-dependent; transcription, DNA-dependent; cytosol; nucleus; protein binding;
HMGA1	5	regulation of transcription, DNA-dependent; transcription, DNA-dependent; cytosol; nucleus; protein binding;
PRKAA1	5	regulation of transcription, DNA-dependent; transcription, DNA-dependent; cytosol; nucleus; protein binding;
WASL	5	regulation of transcription, DNA-dependent; transcription, DNA-dependent; cytosol; nucleus; protein binding;
MEN1	5	transcription, DNA-dependent; gene expression; cytosol; nucleus; protein binding;
NEDD4L	5	transcription, DNA-dependent; gene expression; cytosol; nucleus; protein binding;
CLNS1A	5	gene expression; RNA metabolic process; cytosol; nucleus; protein binding;
MAPK3	5	gene expression; cytokine-mediated signaling pathway; cytosol; nucleus; protein binding;
PSMA8	5	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; nucleus;
PSMB7	5	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; protein binding;
PSMD5	5	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; protein binding;
PSMD7	5	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; protein binding;
RPL13	5	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; protein binding;
RPL14	5	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; protein binding;
RPS9	5	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; protein binding;
SNRPD1	5	gene expression; RNA metabolic process; cytosol; nucleus; protein binding;
XPO1	5	gene expression; mRNA metabolic process; RNA metabolic process; cytosol; protein binding;

Genes shared at least 2 KEGG pathways with RQCD1 (count: 0)

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Region: chr2:219433303..219461803 View in gBrowse