ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DDX6
Previous Symbol	HLR2
Symbol Alias	RCK
Approved Name	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
Previous Name	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD)
Location	11q23.3
Position	chr11:118618472-118661972, -
External Links	HGNC: 2747 Entrez Gene: 1656 Ensembl: ENSG00000110367 UCSC: uc001puc.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000932	cytoplasmic mRNA processing body	Cellular Component		7
GO:0003723	RNA binding	Molecular Function		104
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	Biological Process		7
GO:0005524	ATP binding	Molecular Function		228
GO:0005515	protein binding	Molecular Function	IPI[16364915]	910
GO:0004386	helicase activity	Molecular Function	TAS[1394235]	4
GO:0003724	RNA helicase activity	Molecular Function	TAS[1579499]	4
GO:0010494	cytoplasmic stress granule	Cellular Component	IDA[17392519]	4
GO:0010467	gene expression	Biological Process		140
GO:0008026	ATP-dependent helicase activity	Molecular Function		9
GO:0005829	cytosol	Cellular Component		447
GO:0033962	cytoplasmic mRNA processing body assembly	Biological Process		4
GO:0016442	RNA-induced silencing complex	Cellular Component		1
GO:0016071	mRNA metabolic process	Biological Process		34
GO:0016070	RNA metabolic process	Biological Process		46
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	Biological Process		4

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03018	RNA degradation	8	The correct processing, quality control and turnover of cell...... The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex. More...

Genes shared at least 5 GO terms with DDX6 (count: 30)

Gene Symbol	Pathway Count	Pathway List
PATL1	10	cytoplasmic mRNA processing body; RNA binding; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; protein binding; gene expression; cytosol; cytoplasmic mRNA processing body assembly; mRNA metabolic process; RNA metabolic process; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;
LSM4	8	RNA binding; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;
PSMC3	7	cytoplasmic mRNA processing body; ATP binding; protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
RQCD1	7	cytoplasmic mRNA processing body; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
CNOT6	7	RNA binding; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
DCPS	7	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;
NCBP1	6	RNA binding; protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
RPL13	6	RNA binding; protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
RPL14	6	RNA binding; protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
XPO1	6	RNA binding; protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
HSPA8	6	ATP binding; protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
SMG1	6	ATP binding; protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
ATXN2	5	RNA binding; protein binding; cytoplasmic stress granule; cytoplasmic mRNA processing body assembly; RNA metabolic process;
FAU	5	RNA binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
RPL12	5	RNA binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
RPL37	5	RNA binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
RPL38	5	RNA binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
RPS15A	5	RNA binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
RPS25	5	RNA binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
SNRPD1	5	RNA binding; protein binding; gene expression; cytosol; RNA metabolic process;
SNRPG	5	RNA binding; protein binding; gene expression; cytosol; RNA metabolic process;
TNKS1BP1	5	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
PSMB7	5	protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
PSMD5	5	protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
PSMD7	5	protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
RPS3	5	protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
RPS9	5	protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
SMG7	5	protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
UBB	5	protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;
UBC	5	protein binding; gene expression; cytosol; mRNA metabolic process; RNA metabolic process;

Genes shared at least 2 KEGG pathways with DDX6 (count: 0)

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Region: chr11:118618472..118661972 View in gBrowse