ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PSMB7
Symbol Alias	Z
Approved Name	proteasome (prosome, macropain) subunit, beta type, 7
Location	9q34.11-q34.12
Position	chr9:127115745-127177723, -1
External Links	HGNC: 9544 Entrez Gene: 5695 Ensembl: ENSG00000136930 UCSC: uc004boj.4
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q33	chr9:117700000-130300000	2 (1/1/0)

Gene related GO terms (count: 30)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	biological process	TAS	14
GO:0019048	virus-host interaction	biological process	IEA	61
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	12
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	10
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	biological process	TAS	18
GO:0006915	apoptotic process	biological process	TAS	127
GO:0010467	gene expression	biological process	TAS	154
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	biological process	TAS	10
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	12
GO:0016032	viral reproduction	biological process	TAS	66
GO:0006521	regulation of cellular amino acid metabolic process	biological process	TAS	9
GO:0016071	mRNA metabolic process	biological process	TAS	41
GO:0005839	proteasome core complex	cellular component	ISS	1
GO:0000209	protein polyubiquitination	biological process	TAS	26
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0000084	S phase of mitotic cell cycle	biological process	TAS	19
GO:0000216	M/G1 transition of mitotic cell cycle	biological process	TAS	12
GO:0005829	cytosol	cellular component	TAS	485
GO:0000075	cell cycle checkpoint	biological process	TAS	21
GO:0042981	regulation of apoptotic process	biological process	TAS	34
GO:0005515	protein binding	molecular function	IPI	1015
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological process	TAS	14
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	biological process	TAS	14
GO:0000082	G1/S transition of mitotic cell cycle	biological process	TAS	27
GO:0016070	RNA metabolic process	biological process	TAS	54
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	30
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0004298	threonine-type endopeptidase activity	molecular function	IEA	3
GO:0000278	mitotic cell cycle	biological process	TAS	66
GO:0000502	proteasome complex	cellular component	TAS[8811196]	14

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03050	Proteasome	2

Genes shared at least 5 GO terms with PSMB7 (count: 70)

Gene Symbol	Pathway Count	Pathway List
PSMC3	28	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; virus-host interaction; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; apoptotic process; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; viral reproduction; regulation of cellular amino acid metabolic process; mRNA metabolic process; protein polyubiquitination; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; cytosol; cell cycle checkpoint; regulation of apoptotic process; protein binding; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; G1/S transition of mitotic cell cycle; RNA metabolic process; cellular nitrogen compound metabolic process; small molecule metabolic process; mitotic cell cycle; proteasome complex;
PSMD7	27	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; apoptotic process; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; viral reproduction; regulation of cellular amino acid metabolic process; mRNA metabolic process; protein polyubiquitination; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; cytosol; cell cycle checkpoint; regulation of apoptotic process; protein binding; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; G1/S transition of mitotic cell cycle; RNA metabolic process; cellular nitrogen compound metabolic process; small molecule metabolic process; mitotic cell cycle; proteasome complex;
PSMD5	27	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; apoptotic process; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; viral reproduction; regulation of cellular amino acid metabolic process; mRNA metabolic process; protein polyubiquitination; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; cytosol; cell cycle checkpoint; regulation of apoptotic process; protein binding; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; G1/S transition of mitotic cell cycle; RNA metabolic process; cellular nitrogen compound metabolic process; small molecule metabolic process; mitotic cell cycle; proteasome complex;
PSME1	26	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; apoptotic process; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; viral reproduction; regulation of cellular amino acid metabolic process; mRNA metabolic process; protein polyubiquitination; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; cytosol; cell cycle checkpoint; regulation of apoptotic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; G1/S transition of mitotic cell cycle; RNA metabolic process; cellular nitrogen compound metabolic process; small molecule metabolic process; mitotic cell cycle; proteasome complex;
PSME2	26	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; apoptotic process; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; viral reproduction; regulation of cellular amino acid metabolic process; mRNA metabolic process; protein polyubiquitination; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; cytosol; cell cycle checkpoint; regulation of apoptotic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; G1/S transition of mitotic cell cycle; RNA metabolic process; cellular nitrogen compound metabolic process; small molecule metabolic process; mitotic cell cycle; proteasome complex;
UBB	23	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; apoptotic process; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; viral reproduction; mRNA metabolic process; protein polyubiquitination; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; cytosol; cell cycle checkpoint; regulation of apoptotic process; protein binding; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; G1/S transition of mitotic cell cycle; RNA metabolic process; mitotic cell cycle;
UBC	23	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; apoptotic process; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; viral reproduction; mRNA metabolic process; protein polyubiquitination; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; cytosol; cell cycle checkpoint; regulation of apoptotic process; protein binding; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; G1/S transition of mitotic cell cycle; RNA metabolic process; mitotic cell cycle;
PSMA8	23	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; apoptotic process; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; viral reproduction; regulation of cellular amino acid metabolic process; mRNA metabolic process; protein polyubiquitination; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; cytosol; cell cycle checkpoint; regulation of apoptotic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; RNA metabolic process; cellular nitrogen compound metabolic process; small molecule metabolic process; threonine-type endopeptidase activity; mitotic cell cycle;
XPO1	9	virus-host interaction; gene expression; viral reproduction; mRNA metabolic process; nucleoplasm; cytosol; protein binding; RNA metabolic process; mitotic cell cycle;
CDC26	9	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; cytosol; cell cycle checkpoint; protein binding; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle;
ANAPC4	8	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; cytosol; cell cycle checkpoint; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle;
SKP2	8	protein polyubiquitination; nucleoplasm; S phase of mitotic cell cycle; cytosol; protein binding; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; G1/S transition of mitotic cell cycle; mitotic cell cycle;
PLK1	7	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; cytosol; protein binding; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle;
NCBP1	7	gene expression; viral reproduction; mRNA metabolic process; nucleoplasm; cytosol; protein binding; RNA metabolic process;
RPS2	7	gene expression; viral reproduction; mRNA metabolic process; nucleoplasm; cytosol; protein binding; RNA metabolic process;
CDT1	7	nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; cytosol; protein binding; G1/S transition of mitotic cell cycle; mitotic cell cycle;
CDC45	7	nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; cell cycle checkpoint; protein binding; G1/S transition of mitotic cell cycle; mitotic cell cycle;
MAPK3	6	virus-host interaction; apoptotic process; gene expression; nucleoplasm; cytosol; protein binding;
RAN	6	virus-host interaction; gene expression; viral reproduction; nucleoplasm; cytosol; protein binding;
HSPA8	6	virus-host interaction; gene expression; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
TCEB1	6	virus-host interaction; gene expression; viral reproduction; nucleoplasm; cytosol; protein binding;
RPS9	6	gene expression; viral reproduction; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
RPL14	6	gene expression; viral reproduction; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
RNPS1	6	gene expression; mRNA metabolic process; nucleoplasm; cytosol; protein binding; RNA metabolic process;
RPL13	6	gene expression; viral reproduction; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
RPL27A	6	gene expression; viral reproduction; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
RPS10	6	gene expression; viral reproduction; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
RPS3	6	gene expression; viral reproduction; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
CCND1	6	nucleoplasm; S phase of mitotic cell cycle; cytosol; protein binding; G1/S transition of mitotic cell cycle; mitotic cell cycle;
RRM2	6	nucleoplasm; cytosol; protein binding; G1/S transition of mitotic cell cycle; small molecule metabolic process; mitotic cell cycle;
NCF2	5	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; cytosol; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I;
SEC61B	5	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; gene expression; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I;
CREBBP	5	virus-host interaction; gene expression; nucleoplasm; protein binding; small molecule metabolic process;
CUL5	5	virus-host interaction; viral reproduction; cytosol; protein binding; G1/S transition of mitotic cell cycle;
MAPK1	5	virus-host interaction; apoptotic process; nucleoplasm; cytosol; protein binding;
HMGA1	5	virus-host interaction; viral reproduction; nucleoplasm; cytosol; protein binding;
NXF1	5	virus-host interaction; gene expression; nucleoplasm; cytosol; protein binding;
NEDD4L	5	virus-host interaction; gene expression; nucleoplasm; cytosol; protein binding;
BANF1	5	virus-host interaction; viral reproduction; nucleoplasm; cytosol; protein binding;
RPL12	5	gene expression; viral reproduction; mRNA metabolic process; cytosol; RNA metabolic process;
RPL3L	5	gene expression; viral reproduction; mRNA metabolic process; cytosol; RNA metabolic process;
SNRPD2	5	gene expression; nucleoplasm; cytosol; protein binding; RNA metabolic process;
DDX6	5	gene expression; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
DCPS	5	gene expression; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
RPL35	5	gene expression; viral reproduction; mRNA metabolic process; cytosol; RNA metabolic process;
RQCD1	5	gene expression; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
PAIP1	5	gene expression; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
PATL1	5	gene expression; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
RPL38	5	gene expression; viral reproduction; mRNA metabolic process; cytosol; RNA metabolic process;
FAU	5	gene expression; viral reproduction; mRNA metabolic process; cytosol; RNA metabolic process;
SNRPD1	5	gene expression; nucleoplasm; cytosol; protein binding; RNA metabolic process;
GEMIN2	5	gene expression; nucleoplasm; cytosol; protein binding; RNA metabolic process;
RPL37	5	gene expression; viral reproduction; mRNA metabolic process; cytosol; RNA metabolic process;
SMG1	5	gene expression; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
SNRPB	5	gene expression; nucleoplasm; cytosol; protein binding; RNA metabolic process;
SNRPD3	5	gene expression; nucleoplasm; cytosol; protein binding; RNA metabolic process;
TCEB2	5	gene expression; viral reproduction; nucleoplasm; cytosol; protein binding;
SMG7	5	gene expression; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
SNRPG	5	gene expression; nucleoplasm; cytosol; protein binding; RNA metabolic process;
RPS15A	5	gene expression; viral reproduction; mRNA metabolic process; cytosol; RNA metabolic process;
PARN	5	gene expression; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
SMC1A	5	gene expression; nucleoplasm; cell cycle checkpoint; protein binding; mitotic cell cycle;
LSM4	5	gene expression; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
RPS25	5	gene expression; viral reproduction; mRNA metabolic process; cytosol; RNA metabolic process;
CNOT6	5	gene expression; mRNA metabolic process; cytosol; protein binding; RNA metabolic process;
RPL37A	5	gene expression; viral reproduction; mRNA metabolic process; cytosol; RNA metabolic process;
RPS12	5	gene expression; viral reproduction; mRNA metabolic process; cytosol; RNA metabolic process;
NUP160	5	viral reproduction; cytosol; protein binding; small molecule metabolic process; mitotic cell cycle;
POLA2	5	nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; mitotic cell cycle;
DHFRP1	5	nucleoplasm; cytosol; G1/S transition of mitotic cell cycle; small molecule metabolic process; mitotic cell cycle;

Genes shared at least 2 KEGG pathways with PSMB7 (count: 0)

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Region: chr9:127115745..127177723 View in gBrowse