ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PATL1
Symbol Alias	FLJ36874
Approved Name	protein associated with topoisomerase II homolog 1 (yeast)
Location	11q12.1
Position	chr11:59404189-59436511, -
External Links	HGNC: 26721 Entrez Gene: 219988 Ensembl: ENSG00000166889 UCSC: uc001noe.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	No. of Genes in ADHDgene
GO:0043231	intracellular membrane-bounded organelle	Cellular Component	62
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	Biological Process	4
GO:0033962	cytoplasmic mRNA processing body assembly	Biological Process	4
GO:0034046	poly(G) RNA binding	Molecular Function	2
GO:0016607	nuclear speck	Cellular Component	34
GO:0030014	CCR4-NOT complex	Cellular Component	1
GO:0016071	mRNA metabolic process	Biological Process	34
GO:0016605	PML body	Cellular Component	10
GO:0010467	gene expression	Biological Process	140
GO:0016070	RNA metabolic process	Biological Process	46
GO:0005829	cytosol	Cellular Component	447
GO:0008266	poly(U) RNA binding	Molecular Function	3
GO:0003723	RNA binding	Molecular Function	104
GO:0005515	protein binding	Molecular Function	910
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	Biological Process	7
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	Biological Process	2
GO:0000932	cytoplasmic mRNA processing body	Cellular Component	7

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03018	RNA degradation	8	The correct processing, quality control and turnover of cell...... The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex. More...

Genes shared at least 5 GO terms with PATL1 (count: 29)

Gene Symbol	Pathway Count	Pathway List
DDX6	10	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; cytoplasmic mRNA processing body assembly; mRNA metabolic process; gene expression; RNA metabolic process; cytosol; RNA binding; protein binding; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; cytoplasmic mRNA processing body;
DCPS	8	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; mRNA metabolic process; gene expression; RNA metabolic process; cytosol; protein binding; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; deadenylation-dependent decapping of nuclear-transcribed mRNA;
LSM4	8	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; mRNA metabolic process; gene expression; RNA metabolic process; cytosol; RNA binding; protein binding; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
CNOT6	7	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; RNA binding; protein binding; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
RQCD1	7	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; protein binding; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; cytoplasmic mRNA processing body;
NCBP1	6	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; RNA binding; protein binding;
PSMC3	6	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; protein binding; cytoplasmic mRNA processing body;
RPL13	6	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; RNA binding; protein binding;
RPL14	6	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; RNA binding; protein binding;
XPO1	6	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; RNA binding; protein binding;
FAU	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; RNA binding;
HSPA8	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; protein binding;
PSMB7	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; protein binding;
PSMD5	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; protein binding;
PSMD7	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; protein binding;
RPL12	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; RNA binding;
RPL37	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; RNA binding;
RPL38	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; RNA binding;
RPS15A	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; RNA binding;
RPS25	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; RNA binding;
RPS3	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; protein binding;
RPS9	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; protein binding;
SMG1	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; protein binding;
SMG7	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; protein binding;
TNKS1BP1	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
UBB	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; protein binding;
UBC	5	mRNA metabolic process; gene expression; RNA metabolic process; cytosol; protein binding;
SNRPD1	5	gene expression; RNA metabolic process; cytosol; RNA binding; protein binding;
SNRPG	5	gene expression; RNA metabolic process; cytosol; RNA binding; protein binding;

Genes shared at least 2 KEGG pathways with PATL1 (count: 0)

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Region: chr11:59404189..59436511 View in gBrowse