ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CDC45
Previous Symbol	CDC45L2, CDC45L
Approved Name	cell division cycle 45 homolog (S. cerevisiae)
Previous Name	CDC45 (cell division cycle 45, S.cerevisiae, homolog)-like, "CDC45 cell division cycle 45-like (S. cerevisiae)"
Name Alias	human CDC45
Location	22q11.21
Position	chr22:19466982-19508135, +
External Links	HGNC: 1739 Entrez Gene: 8318 Ensembl: ENSG00000093009 UCSC: uc002zpr.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_41	chr22:17616020-19792353 (NCBI36 / hg18)	2176334	22q11.21	dup
CNV_Jarick[2012]_40	chr22:17257787-19792353 (NCBI36 / hg18)	2534567	22q11.21	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000075	cell cycle checkpoint	Biological Process		21
GO:0000076	DNA replication checkpoint	Biological Process	TAS[9660782]	3
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process		26
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	Biological Process		7
GO:0000084	S phase of mitotic cell cycle	Biological Process		20
GO:0000216	M/G1 transition of mitotic cell cycle	Biological Process		13
GO:0005515	protein binding	Molecular Function	IPI[17887956]	910
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005634	nucleus	Cellular Component		770
GO:0005813	centrosome	Cellular Component		71
GO:0005737	cytoplasm	Cellular Component		690
GO:0006270	DNA replication initiation	Biological Process		3
GO:0006260	DNA replication	Biological Process		27
GO:0006271	DNA strand elongation involved in DNA replication	Biological Process		6

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04110	Cell cycle	19	Mitotic cell cycle progression is accomplished through a rep...... Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. More...

Genes shared at least 5 GO terms with CDC45 (count: 36)

Gene Symbol	Pathway Count	Pathway List
CDT1	10	DNA replication checkpoint; G1/S transition of mitotic cell cycle; regulation of transcription involved in G1/S phase of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein binding; mitotic cell cycle; nucleoplasm; nucleus; DNA replication;
POLA2	10	G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; nucleoplasm; nucleus; cytoplasm; DNA replication initiation; DNA replication; DNA strand elongation involved in DNA replication;
PSMC3	9	cell cycle checkpoint; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein binding; mitotic cell cycle; nucleoplasm; nucleus; cytoplasm;
POLE	8	G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; nucleoplasm; nucleus; DNA replication initiation; DNA replication;
PSMB7	7	cell cycle checkpoint; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein binding; mitotic cell cycle; nucleoplasm;
PSMD5	7	cell cycle checkpoint; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein binding; mitotic cell cycle; nucleoplasm;
PSMD7	7	cell cycle checkpoint; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein binding; mitotic cell cycle; nucleoplasm;
PSME1	7	cell cycle checkpoint; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; nucleoplasm; cytoplasm;
RAD9A	7	cell cycle checkpoint; DNA replication checkpoint; protein binding; nucleoplasm; nucleus; cytoplasm; DNA replication;
UBB	7	cell cycle checkpoint; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein binding; mitotic cell cycle; nucleoplasm;
UBC	7	cell cycle checkpoint; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein binding; mitotic cell cycle; nucleoplasm;
RRM2	7	G1/S transition of mitotic cell cycle; regulation of transcription involved in G1/S phase of mitotic cell cycle; protein binding; mitotic cell cycle; nucleoplasm; cytoplasm; DNA replication;
FEN1	7	S phase of mitotic cell cycle; protein binding; mitotic cell cycle; nucleoplasm; nucleus; DNA replication; DNA strand elongation involved in DNA replication;
POLD4	7	S phase of mitotic cell cycle; protein binding; mitotic cell cycle; nucleoplasm; nucleus; DNA replication; DNA strand elongation involved in DNA replication;
CHEK1	6	cell cycle checkpoint; protein binding; nucleoplasm; nucleus; centrosome; DNA replication;
PSME2	6	cell cycle checkpoint; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; nucleoplasm;
RFWD2	6	cell cycle checkpoint; protein binding; nucleoplasm; nucleus; centrosome; cytoplasm;
SMC1A	6	cell cycle checkpoint; protein binding; mitotic cell cycle; nucleoplasm; nucleus; cytoplasm;
CCND1	6	G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; protein binding; mitotic cell cycle; nucleoplasm; nucleus;
POLD3	6	S phase of mitotic cell cycle; protein binding; mitotic cell cycle; nucleoplasm; nucleus; DNA strand elongation involved in DNA replication;
DDB1	5	cell cycle checkpoint; protein binding; nucleoplasm; nucleus; cytoplasm;
PSMA8	5	cell cycle checkpoint; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; nucleus;
RAD1	5	cell cycle checkpoint; protein binding; nucleoplasm; nucleus; DNA replication;
HINFP	5	G1/S transition of mitotic cell cycle; regulation of transcription involved in G1/S phase of mitotic cell cycle; protein binding; nucleoplasm; nucleus;
RCC1	5	G1/S transition of mitotic cell cycle; protein binding; nucleoplasm; nucleus; cytoplasm;
SKP2	5	G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; protein binding; mitotic cell cycle; nucleoplasm;
GINS2	5	S phase of mitotic cell cycle; protein binding; mitotic cell cycle; nucleoplasm; DNA strand elongation involved in DNA replication;
CEP164	5	protein binding; mitotic cell cycle; nucleus; centrosome; cytoplasm;
CEP57	5	protein binding; mitotic cell cycle; nucleus; centrosome; cytoplasm;
DHX9	5	protein binding; nucleoplasm; nucleus; centrosome; cytoplasm;
KIF23	5	protein binding; mitotic cell cycle; nucleoplasm; nucleus; centrosome;
NUMA1	5	protein binding; mitotic cell cycle; nucleoplasm; nucleus; cytoplasm;
PAFAH1B1	5	protein binding; mitotic cell cycle; nucleus; centrosome; cytoplasm;
PLK1	5	protein binding; mitotic cell cycle; nucleoplasm; nucleus; centrosome;
SMC3	5	protein binding; mitotic cell cycle; nucleoplasm; nucleus; cytoplasm;
SSRP1	5	protein binding; nucleoplasm; nucleus; cytoplasm; DNA replication;

Genes shared at least 2 KEGG pathways with CDC45 (count: 0)

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Region: chr22:19466982..19508135 View in gBrowse