ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CDC45
Previous Symbol	CDC45L2, CDC45L
Approved Name	cell division cycle 45
Previous Name	"CDC45 (cell division cycle 45, S.cerevisiae, homolog)-like", "CDC45 cell division cycle 45-like (S. cerevisiae)", "cell division cycle 45 homolog (S. cerevisiae)"
Name Alias	"human CDC45"
Location	22q11.21
Position	chr22:19466982-19508135, 1
External Links	HGNC: 1739 Entrez Gene: 8318 Ensembl: ENSG00000093009 UCSC: uc011aha.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_41	chr22:17616020-19792353 (NCBI36 / hg18)	2176334	22q11.21	dup
CNV_Jarick[2012]_40	chr22:17257787-19792353 (NCBI36 / hg18)	2534567	22q11.21	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006260	DNA replication	biological process	TAS	31
GO:0005515	protein binding	molecular function	IPI[17887956]	1015
GO:0000082	G1/S transition of mitotic cell cycle	biological process	TAS	27
GO:0005813	centrosome	cellular component	IDA	78
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0000084	S phase of mitotic cell cycle	biological process	TAS	19
GO:0000216	M/G1 transition of mitotic cell cycle	biological process	TAS	12
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	biological process	TAS	7
GO:0000076	DNA replication checkpoint	biological process	TAS[9660782]	3
GO:0000278	mitotic cell cycle	biological process	TAS	66
GO:0005737	cytoplasm	cellular component	IEA	781
GO:0000075	cell cycle checkpoint	biological process	TAS	21
GO:0006270	DNA replication initiation	biological process	IEA	2
GO:0006271	DNA strand elongation involved in DNA replication	biological process	TAS	6
GO:0005634	nucleus	cellular component	IDA	877

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CDC45 (count: 35)

Gene Symbol	Pathway Count	Pathway List
CDT1	10	DNA replication; protein binding; G1/S transition of mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; regulation of transcription involved in G1/S phase of mitotic cell cycle; DNA replication checkpoint; mitotic cell cycle; nucleus;
POLA2	10	DNA replication; G1/S transition of mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; cytoplasm; DNA replication initiation; DNA strand elongation involved in DNA replication; nucleus;
PSMC3	9	protein binding; G1/S transition of mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; cytoplasm; cell cycle checkpoint; nucleus;
RRM2	7	DNA replication; protein binding; G1/S transition of mitotic cell cycle; nucleoplasm; regulation of transcription involved in G1/S phase of mitotic cell cycle; mitotic cell cycle; cytoplasm;
RAD9A	7	DNA replication; protein binding; nucleoplasm; DNA replication checkpoint; cytoplasm; cell cycle checkpoint; nucleus;
POLD4	7	DNA replication; protein binding; nucleoplasm; S phase of mitotic cell cycle; mitotic cell cycle; DNA strand elongation involved in DNA replication; nucleus;
FEN1	7	DNA replication; protein binding; nucleoplasm; S phase of mitotic cell cycle; mitotic cell cycle; DNA strand elongation involved in DNA replication; nucleus;
PSMD7	7	protein binding; G1/S transition of mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; cell cycle checkpoint;
PSMB7	7	protein binding; G1/S transition of mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; cell cycle checkpoint;
PSMD5	7	protein binding; G1/S transition of mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; cell cycle checkpoint;
UBC	7	protein binding; G1/S transition of mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; cell cycle checkpoint;
UBB	7	protein binding; G1/S transition of mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; cell cycle checkpoint;
PSME1	7	G1/S transition of mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; cytoplasm; cell cycle checkpoint;
CHEK1	6	DNA replication; protein binding; centrosome; nucleoplasm; cell cycle checkpoint; nucleus;
POLD3	6	protein binding; nucleoplasm; S phase of mitotic cell cycle; mitotic cell cycle; DNA strand elongation involved in DNA replication; nucleus;
CCND1	6	protein binding; G1/S transition of mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle; mitotic cell cycle; nucleus;
MAD1L1	6	protein binding; centrosome; mitotic cell cycle; cytoplasm; cell cycle checkpoint; nucleus;
SMC1A	6	protein binding; nucleoplasm; mitotic cell cycle; cytoplasm; cell cycle checkpoint; nucleus;
PSME2	6	G1/S transition of mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; cell cycle checkpoint;
RAD1	5	DNA replication; protein binding; nucleoplasm; cell cycle checkpoint; nucleus;
SSRP1	5	DNA replication; protein binding; nucleoplasm; cytoplasm; nucleus;
CEP164	5	protein binding; centrosome; mitotic cell cycle; cytoplasm; nucleus;
SKP2	5	protein binding; G1/S transition of mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle; mitotic cell cycle;
RCC1	5	protein binding; G1/S transition of mitotic cell cycle; nucleoplasm; cytoplasm; nucleus;
PAFAH1B1	5	protein binding; centrosome; mitotic cell cycle; cytoplasm; nucleus;
KIF23	5	protein binding; centrosome; nucleoplasm; mitotic cell cycle; nucleus;
DHX9	5	protein binding; centrosome; nucleoplasm; cytoplasm; nucleus;
GINS2	5	protein binding; nucleoplasm; S phase of mitotic cell cycle; mitotic cell cycle; DNA strand elongation involved in DNA replication;
HINFP	5	protein binding; G1/S transition of mitotic cell cycle; nucleoplasm; regulation of transcription involved in G1/S phase of mitotic cell cycle; nucleus;
SMC3	5	protein binding; nucleoplasm; mitotic cell cycle; cytoplasm; nucleus;
CEP57	5	protein binding; centrosome; mitotic cell cycle; cytoplasm; nucleus;
DDB1	5	protein binding; nucleoplasm; cytoplasm; cell cycle checkpoint; nucleus;
PLK1	5	protein binding; centrosome; nucleoplasm; mitotic cell cycle; nucleus;
NUMA1	5	protein binding; nucleoplasm; mitotic cell cycle; cytoplasm; nucleus;
PSMA8	5	S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; cell cycle checkpoint; nucleus;

Genes shared at least 2 KEGG pathways with CDC45 (count: 0)

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Region: chr22:19466982..19508135 View in gBrowse